Výsledky vyhledávání - "Lisa G. McWilliams"

Akademický článek

Botulinum Neurotoxin Detection and Differentiation by Mass Spectrometry

Autor: John R. Barr, Hercules Moura, Anne E. Boyer, Adrian R. Woolfitt, Suzanne R. Kalb, Antonis Pavlopoulos, Lisa G. McWilliams, Jurgen G. Schmidt, Rodolfo A. Martinez, David C. Ashley

Publikováno v: Emerging Infectious Diseases, Vol 11, Iss 10, Pp 1578-1583 (2005)

Botulinum neurotoxins (BoNTs) are proteases that cleave specific cellular proteins essential for neurotransmitter release. Seven BoNT serotypes (A–G) exist; 4 usually cause human botulism (A, B, E, and F). We developed a rapid, mass spectrometry–

Externí odkaz: https://doaj.org/article/6d55ea1c32614f4abbcdab2ba271115d

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Simultaneous Quantification of Free Cholesterol, Cholesteryl Esters, and Triglycerides without Ester Hydrolysis by UHPLC Separation and In-Source Collision Induced Dissociation Coupled MS/MS

Autor: James L. Pirkle, Zsuzsanna Kuklenyik, Lisa G. McWilliams, Michael S. Gardner, Jeffrey I. Jones, John R. Barr

Publikováno v: Journal of the American Society for Mass Spectrometry

We demonstrate the application of in-source nitrogen collision-induced dissociation (CID) that eliminates the need for ester hydrolysis before simultaneous analysis of esterified cholesterol (EC) and triglycerides (TG) along with free cholesterol (FC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d68df70b5968496b210eaf9ab1f79cd
http://europepmc.org/articles/PMC5645443

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On-column trypsin digestion coupled with LC-MS/MS for quantification of apolipoproteins

Autor: David M. Schieltz, Jeffrey I. Jones, Michael L. Andrews, Jon Rees, Lisa G. McWilliams, Michael S. Gardner, John R. Barr, James L. Pirkle, Christopher A. Toth, Bryan A. Parks, Zsuzsanna Kuklenyik

Publikováno v: J Proteomics

Apolipoproteins measured in plasma or serum are potential biomarkers for assessing metabolic irregularities that are associated with the development of cardiovascular disease (CVD). LC-MS/MS allows quantitative measurement of multiple apolipoproteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9841cb327116ece657ab9e1e77b67f0a
https://doi.org/10.1016/j.jprot.2016.09.011

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Abstract 548: Separation of Lipoprotein Particles Utilizing Asymmetric Flow Field-flow Fractionation and Quantitation of Apolipoprotein L1 in Human Plasma with IMER-UPLC-MS/MS

Autor: Bryan A. Parks, Zsuzsanna Kuklenyik, Christopher Toth, Yulanda M. Williamson, Lisa G. McWilliams, Michael G. Gardner, David M. Schieltz, Michael L. Andrews, Kevin Bierbaum, Jon Rees, Anthony Lehtikoski, John R. Barr

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 38

Apolipoprotein L1 (ApoL1) is an intriguing protein and was shown to be involved in numerous diseases states such as chronic kidney disease (CKD), cardiovascular diseases(CVD), Human Immunodeficiency Virus associated Nephropathy (HIVAN), systemic lupu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5c0e9ea729c2bc5c3650e8f6ed7cfcc
https://doi.org/10.1161/atvb.38.suppl_1.548

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Multivariate DoE Optimization of Asymmetric Flow Field Flow Fractionation Coupled to Quantitative LC-MS/MS for Analysis of Lipoprotein Subclasses

Autor: Yulanda M. Williamson, Lisa G. McWilliams, James L. Pirkle, Jon Rees, David M. Schieltz, Michael S. Gardner, John R. Barr, Bryan A. Parks, Zsuzsanna Kuklenyik

Publikováno v: Chromatography, Vol 2, Iss 1, Pp 96-117 (2015)
Chromatography
Volume 2
Issue 1
Pages 96-117

In this report we demonstrate a practical multivariate design of experiment (DoE) approach for asymmetric flow field-flow fractionation (AF4) method optimization using separation of lipoprotein subclasses as an example. First, with the aid of commerc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fef57d8b8b01873668428f7234d1804
http://www.mdpi.com/2227-9075/2/1/96

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Abstract 568: Lipidomic Comparison of Hyperglycemic and Normal Subjects Using Absolute Quantitation of >700 Lipid Species

Autor: Susan Kuklenyik, Lisa G. McWilliams, John R. Barr, Jon Rees, Bryan A. Parks, David M. Schieltz, Christopher Toth, Michael G. Gardner, Michael L. Andrews, Jeffrey Jones

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 37

The presence of diabetes mellitus in patients significantly increases the risk of cardiovascular disease, among many negative health outcomes. Several research groups have reported lipid species anomalies in subjects showing insulin resistance, inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52085811067724c59622f2341accf509
https://doi.org/10.1161/atvb.37.suppl_1.568

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High throughput quantification of apolipoproteins A-I and B-100 by isotope dilution MS targeting fast trypsin releasable peptides without reduction and alkylation

Autor: Jeffrey I. Jones, David M. Schieltz, Lisa G. McWilliams, Christopher A. Toth, John C. Rees, Michael S. Gardner, John R. Barr, Michael L. Andrews, Bryan A. Parks, James L. Pirkle, Zsuzsanna Kuklenyik

Publikováno v: Proteomics. Clinical Applications

PURPOSE Apolipoprotein A-I (ApoA-I) and apolipoprotein B-100 (ApoB-100) are amphipathic proteins that are strong predictors of cardiovascular disease risk. The traceable calibration of apolipoprotein assays is a persistent challenge, especially for A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ab4e6a5a5cd174df4d9800f60dec15
https://pubmed.ncbi.nlm.nih.gov/28296203

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Analysis of active ricin and castor bean proteins in a ricin preparation, castor bean extract, and surface swabs from a public health investigation

Autor: Eduardo Gomez-Saladin, Heather L. Stang, Jon Rees, Bruce N. Newton, Lisa G. McWilliams, John Kools, David M. Schieltz, Sara C. McGrath, Leslie A. Dauphin, Michael J. Vick, Jerry D. Thomas, James L. Pirkle, John R. Barr, Michael D. Bowen

Publikováno v: Forensic Science International. 209:70-79

In late February 2008, law enforcement officials in Las Vegas, Nevada, discovered in a hotel room, a copy of The Anarchist Cookbook, suspected castor beans and a "white powder" thought to be a preparation of ricin. Ricin is a deadly toxin from the se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6391463f658286911f39a932b54dd5e3
https://doi.org/10.1016/j.forsciint.2010.12.013

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Studies on botulinum neurotoxins type/C1 and mosaic/DC using Endopep-MS and proteomics

Autor: Adrian R. Woolfitt, Rebecca R. Terilli, Lisa G. McWilliams, Maribel Gallegos-Candela, Hercules Moura, Maria I. Solano, James L. Pirkle, John R. Barr

Publikováno v: FEMS Immunology & Medical Microbiology. 61:288-300

Botulinum neurotoxins (BoNTs) are very potent toxins and category A biological threat agents. BoNT serotypes /C1 and /D affect birds and mammals and can be potentially lethal to humans. We have previously described the usefulness of the Endopep-MS me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73acfc1ce8dec159c0b24818a3cab1d
https://doi.org/10.1111/j.1574-695x.2010.00774.x

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