Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Lisa F, Boyd"'
Autor:
Jiansheng Jiang, Christopher T. Boughter, Javeed Ahmad, Kannan Natarajan, Lisa F. Boyd, Martin Meier-Schellersheim, David H. Margulies
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract The COVID-19 pandemic and SARS-CoV-2 variants have dramatically illustrated the need for a better understanding of antigen (epitope)-antibody (paratope) interactions. To gain insight into the immunogenic characteristics of epitopic sites (ES
Externí odkaz:
https://doaj.org/article/a054579999df4ca3962667ef9a71ae44
Autor:
Jiansheng Jiang, Daniel K. Taylor, Ellen J. Kim, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Hau V. Truong, Claire H. Woodward, Nikolaos G. Sgourakis, Peter Cresswell, David H. Margulies, Kannan Natarajan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The catalytic chaperone tapasin assists peptide loading onto MHC-I molecules for antigen presentation and immune recognition. Here, the authors present crystal structures that provide insights into the molecular mechanism of tapasin-mediated peptide
Externí odkaz:
https://doaj.org/article/c0903e0c423a49729d8d0a758d83bc5c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Peptide loading of MHC-I molecules plays a critical role in the T cell response to infections and tumors as well as to interactions with inhibitory receptors on natural killer (NK) cells. To facilitate and optimize peptide acquisition, vertebrates ha
Externí odkaz:
https://doaj.org/article/61680c52186a49d0a779f414c450671a
Autor:
David H. Margulies, Daniel K. Taylor, Jiansheng Jiang, Lisa F. Boyd, Javeed Ahmad, Michael G. Mage, Kannan Natarajan
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent on the identification of cell surface MHC molecules bearing peptides generated from either endogenous (MHC I) or exogenous (MHC II) dependent pathways. This
Externí odkaz:
https://doaj.org/article/4f2ff701293a4c0aac80f4c8856fbb79
Autor:
Montserrat Puig, Suryatheja Ananthula, Ramesh Venna, Swamy Kumar Polumuri, Elliot Mattson, Lacey M. Walker, Marco Cardone, Mayumi Takahashi, Shan Su, Lisa F. Boyd, Kannan Natarajan, Galina Abdoulaeva, Wells W. Wu, Gregory Roderiquez, William H. Hildebrand, Serge L. Beaucage, Zhihua Li, David H. Margulies, Michael A. Norcross
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Neoantigen formation due to the interaction of drug molecules with human leukocyte antigen (HLA)-peptide complexes can lead to severe hypersensitivity reactions. Flucloxacillin (FLX), a β-lactam antibiotic for narrow-spectrum gram-positive bacterial
Externí odkaz:
https://doaj.org/article/57a65f7c16ba491cbcf73a5ec2561268
Autor:
Kannan Natarajan, Andrew C. McShan, Jiansheng Jiang, Vlad K Kumirov, Rui Wang, Huaying Zhao, Peter Schuck, Mulualem E. Tilahun, Lisa F. Boyd, Jinfa Ying, Ad Bax, David H. Margulies, Nikolaos G. Sgourakis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Binding of T cell receptors (TCR) to peptide-loaded major histocompatibility complexes (p/MHC) leads to T-cell activation. Here the authors give structural insights into T-cell signalling and show that p/MHC binding induces conformational changes at
Externí odkaz:
https://doaj.org/article/ab8774b12af24665974fefb843895dad
Autor:
Kannan Natarajan, Jiansheng Jiang, Nathan A. May, Michael G. Mage, Lisa F. Boyd, Andrew C. McShan, Nikolaos G. Sgourakis, Ad Bax, David H. Margulies
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Antigen presentation is a cellular process that involves a number of steps, beginning with the production of peptides by proteolysis or aberrant synthesis and the delivery of peptides to cellular compartments where they are loaded on MHC class I (MHC
Externí odkaz:
https://doaj.org/article/b399f764e4124bf6b9d60d4c3f366d5f
Autor:
Arunakumar Gangaplara, Maja Buszko, Lisa F. Boyd, Suveena Sharma, Kannan Natarajan, Abir K. Panda, David H. Margulies, Ethan M. Shevach
Publikováno v:
J Immunol
NK cells recognize MHC class I (MHC-I) Ags via stochastically expressed MHC-I–specific inhibitory receptors that prevent NK cell activation via cytoplasmic ITIM. We have identified a pan anti–MHC-I mAb that blocks NK cell inhibitory receptor bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f18bd17c3d79b2f0232f8143c5af73
https://doi.org/10.4049/jimmunol.2000412
https://doi.org/10.4049/jimmunol.2000412
Autor:
Zhaochun, Chen, Peng, Zhang, Yumiko, Matsuoka, Yaroslav, Tsybovsky, Kamille, West, Celia, Santos, Lisa F, Boyd, Hanh, Nguyen, Anna, Pomerenke, Tyler, Stephens, Adam S, Olia, Baoshan, Zhang, Valeria, De Giorgi, Michael R, Holbrook, Robin, Gross, Elena, Postnikova, Nicole L, Garza, Reed F, Johnson, David H, Margulies, Peter D, Kwong, Harvey J, Alter, Ursula J, Buchholz, Paolo, Lusso, Patrizia, Farci
Publikováno v:
medRxiv
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has triggered a devastating global health, social and economic crisis. The RNA nature and broad circulation of this viru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dde72e12c7ce00b3065a3df8b37a32
https://doi.org/10.1016/j.celrep.2022.111528
https://doi.org/10.1016/j.celrep.2022.111528
Autor:
Jiansheng Jiang, Di Xia, Rick Huang, Allison Zeher, Lisa F. Boyd, Kannan Natarajan, Javeed Ahmad, David H. Margulies
Publikováno v:
The Journal of Biological Chemistry
Research Square
article-version (status) pre
article-version (number) 1
Research Square
article-version (status) pre
article-version (number) 1
Combating the worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of new variants demands understanding of the structural basis of the interaction of antibodies with the SARS-CoV-2 receptor-binding domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8974d893097d656177442f70ecd0e7d4
https://pubmed.ncbi.nlm.nih.gov/34537245
https://pubmed.ncbi.nlm.nih.gov/34537245