Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Lisa Ebihara"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
During accommodation, the lens changes focus by altering its shape following contraction and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be accompanied by fluid flow in and out of individual lens cells. We test
Externí odkaz:
https://doaj.org/article/2af70ed419d24bda88583788aa804e2e
Autor:
Viviana M. Berthoud, Peter J. Minogue, Steve L. Reichow, Lisa Ebihara, Eric C. Beyer, Umair Khan, Jun-Jie Tong, Bassam G. Haddad
Publikováno v:
Biophys J
Connexin-50 (Cx50) is among the most frequently mutated genes associated with congenital cataracts. While most of these disease-linked variants cause loss-of-function due to misfolding or aberrant trafficking, others directly alter channel properties
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
During accommodation, the lens changes focus by altering its shape following contraction and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be accompanied by fluid flow in and out of individual lens cells. We test
Autor:
Peter J. Minogue, Jun-Jie Tong, Kelly Wichmann, Hubert Mysliwiec, Lisa Ebihara, Eric C. Beyer, Viviana M. Berthoud
Publikováno v:
Journal of Biological Chemistry. 298:101673
Many human connexin50 (Cx50) mutants have been linked to cataracts including two carboxyl terminus serine mutants that are known phosphorylation sites in the lens (Cx50S258F and Cx50S259Y). To examine the behavior of these mutants and the role of pho
Autor:
Lisa Ebihara, Jun-Jie Tong, Umair Khan, Bassam G. Haddad, Peter J. Minogue, Eric R. Beyerle, Eric C. Beyer, Viviana M. Berthoud, Steve L. Reichow
Publikováno v:
Biophysical Journal. 121:175a
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Chloride channels have been proposed to play an important role in the regulation of lens volume. Unfortunately, little information is available about the molecular identity of these channels or how they are regulated in the lens due to the di
Autor:
Tung-Ling Chen, Wenji Guo, Viviana M. Berthoud, Peter J. Minogue, Jun-Jie Tong, Lisa Ebihara, Eric C. Beyer
Publikováno v:
American Journal of Physiology-Cell Physiology. 300:C1055-C1064
Gap junction channels, which are made of connexins, are critical for intercellular communication, a function that may be disrupted in a variety of diseases. We studied the consequences of two cataract-associated mutations at adjacent positions at the
Autor:
Benjamin Heilbrunn, Eric C. Beyer, Peter J. Minogue, June Chung, Rebecca K. Zoltoski, L.A. Novak, Lisa Ebihara, Xiaoqin Liu, Jer R. Kuszak, Viviana M. Berthoud
Publikováno v:
Experimental Eye Research. 84:513-528
To examine the effects of increased expression of Cx50 in the mouse lens, transgenic mice were generated using a DNA construct containing the human Cx50 coding region and a C-terminal FLAG epitope driven by the chicken betaB1-crystallin promoter. Exp
Publikováno v:
The Journal of Physiology. 576:787-799
Previous studies have shown that gap junctional channels formed from the lens connexins Cx50 (or its chicken orthologue, Cx45.6) and Cx43 exhibit marked differences in transjunctional voltage gating and unitary conductance. In the present study, we u
Autor:
Andrew D. Krahn, Lynne Danis, Alexandre F.R. Stewart, Xiaoqin Liu, Douglas L. Jones, Gerard M. Guiraudon, Donglin Bai, George Klein, Raymond Yee, Michael H. Gollob, John P. Veinot, Anthony S.L. Tang, Allan C. Skanes, Frédérique Tesson, Lisa Ebihara, Xiang-Qun Gong, Qing Shao
Publikováno v:
New England Journal of Medicine. 354:2677-2688
BACKGROUND Atrial fibrillation is the most common type of cardiac arrhythmia and a leading cause of cardiovascular morbidity, particularly stroke. The cardiac gap-junction protein connexin 40 is expressed selectively in atrial myocytes and mediates t