Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lisa E. Prevette"'
Autor:
Patricia Hahn, Jing Liu, Kaylin G. Earnest, Jack A. Queenan, Ana Luisa Kadekaro, Haizhou Zhu, Edward J. Merino, Safnas F. AbdulSalam, George Gray, Lisa E. Prevette, Gurdat Premnauth
Publikováno v:
Free radical biologymedicine. 134
UV irradiation is a major driver of DNA damage and ultimately skin cancer. UV exposure leads to persistent radicals that generate ROS over prolonged periods of time. Toward the goal of developing long-lasting antioxidants that can penetrate skin, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f32de47bebc6699349b89ec89348eb
https://pubmed.ncbi.nlm.nih.gov/30605714
https://pubmed.ncbi.nlm.nih.gov/30605714
Publikováno v:
Biophysical Chemistry. 207:40-50
Cell-penetrating compounds (CPCs) are often conjugated to drugs and genes to facilitate cellular uptake. We hypothesize that the electrostatic interaction between the positively charged amines of the cell-penetrating compounds and the negatively char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528a5ad31ccea68623def7caac7470ee
https://doi.org/10.1016/j.bpc.2015.08.003
https://doi.org/10.1016/j.bpc.2015.08.003
Publikováno v:
Current Atherosclerosis Reports. 12:267-272
Metabolites reflect the dynamic processes underlying cellular homeostasis. Recent advances in analytical chemistry and molecular biology have set the stage for metabolite profiling to help us understand complex molecular processes and physiology. Met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15de24e5a98545773a6894c418868970
https://doi.org/10.1007/s11883-010-0112-9
https://doi.org/10.1007/s11883-010-0112-9
Publikováno v:
Langmuir. 24:8090-8101
Glycopolymers with repeat units comprised of the disaccharide trehalose and an oligoamine of increasing amine have been previously synthesized by our group and shown to efficiently deliver pDNA (plasmid DNA) to HeLa cells while remaining relatively n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb0e3ecf2e98707e058237bca09c969f
https://doi.org/10.1021/la800120q
https://doi.org/10.1021/la800120q
Publikováno v:
Biophysical chemistry.
Poly(ethylene glycol) (PEG) is often conjugated to polyethylenimine (PEI) to provide colloidal stability to PEI-DNA polyplexes and shield charge leading to toxicity. Here, a library of nine cationic copolymers was synthesized by grafting three molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36773856151bdc957cb1dc63e7a13b7
https://pubmed.ncbi.nlm.nih.gov/26001068
https://pubmed.ncbi.nlm.nih.gov/26001068
Publikováno v:
Journal of the American Chemical Society. 128:8176-8184
Herein, three new glycopolymers have been synthesized via "click polymerization" to promote nucleic acid delivery in the presence of biological media containing serum. These structures were designed to contain a trehalose moiety to promote biocompati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09aac00734100fb1f4c57d6b14474611
https://doi.org/10.1021/ja0585580
https://doi.org/10.1021/ja0585580
The transfer of genetic material into cells using non-viral vectors offers unique potential for therapeutics; however, the efficacy of delivery depends upon a poorly understood, multistep pathway, limiting the prospects for successful gene delivery.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49bb678884abfc5daf8b6420f5b636bf
https://europepmc.org/articles/PMC3436429/
https://europepmc.org/articles/PMC3436429/
Publikováno v:
Biomacromolecules. 11(2)
Previously, a series of three poly(amidoamine)s was designed and synthesized by polymerizing oxylate, succinate, or adipate groups with pentaethylenehexamine. These resulting polymers (named O4, S4, and A4, respectively) were created as models to pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c2736653b00dfee4f27d89f4c16579
https://pubmed.ncbi.nlm.nih.gov/20058912
https://pubmed.ncbi.nlm.nih.gov/20058912
Publikováno v:
Biomaterials. 28(18)
Cationic polymers are currently being studied as non-viral vectors to deliver therapeutic DNA into cells. In this study, a series of trehalose-based glycopolymers containing four secondary amines in the repeat unit were synthesized via the 'click rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf2282e53426c1cb220e718b50e19d2
https://pubmed.ncbi.nlm.nih.gov/17367850
https://pubmed.ncbi.nlm.nih.gov/17367850
Publikováno v:
Langmuir. 23:9773
There is considerable interest in the binding and condensation of DNA with polycations to form polyplexes because of their possible application to cellular nucleic acid delivery. This work focuses on studying the binding of plasmid DNA (pDNA) with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be19b52824ac496d50f7d4f8f512d03
https://doi.org/10.1021/la7009995
https://doi.org/10.1021/la7009995