Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lisa E. Cole"'
Publikováno v:
ACS Nano
Toll-like receptors (TLRs) are a family of proteins that modulate the innate immune system and control the initiation of downstream immune responses. Spherical nucleic acids (SNAs) designed to stimulate single members of the TLR family (e.g., TLR7 or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970654580d452b2887d6a392b0f6f467
https://doi.org/10.1021/acsnano.1c03093
https://doi.org/10.1021/acsnano.1c03093
Autor:
Ziyin Huang, Cassandra E. Callmann, Dai Horiuchi, Chad A. Mirkin, Lisa E. Cole, Caroline D. Kusmierz
Publikováno v:
Proc Natl Acad Sci U S A
Highly heterogenous cancers, such as triple-negative breast cancer (TNBC), remain challenging immunotherapeutic targets. Herein, we describe the synthesis and evaluation of immunotherapeutic liposomal spherical nucleic acids (SNAs) for TNBC therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b865f0a7bf44806d6feee4c4ae37b1af
https://doi.org/10.1073/pnas.2005794117
https://doi.org/10.1073/pnas.2005794117
Publikováno v:
ACS Nano. 14:1084-1092
The synthesis and evaluation of spherical nucleic acids (SNAs) incorporating two physically and chemically distinct classes of oligonucleotides (ODNs) at programmed ratios are described. These SNAs are single entity agents that enter the same target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0310a8892e0e180e1e3398b493190646
https://doi.org/10.1021/acsnano.9b08750
https://doi.org/10.1021/acsnano.9b08750
Smaller CpG-Conjugated Gold Nanoconstructs Achieve Higher Targeting Specificity of Immune Activation
Autor:
Jun Yue, Lisa E. Cole, Chad A. Mirkin, Andrew Lee, Teri W. Odom, Roger M. Pallares, Emma E. Coughlin
Publikováno v:
ACS Applied Materials & Interfaces. 10:21920-21926
This study describes a side-by-side comparison of the in vitro immunostimulatory activity of cytosine-phosphate-guanine (CpG)-conjugated gold nanoparticles. Three different gold nanoparticle cores (13 nm spheres, 50 nm spheres, and 40 nm stars) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab9cd52961de7ef4a58719b295bd3f5
https://doi.org/10.1021/acsami.8b06633
https://doi.org/10.1021/acsami.8b06633
Publikováno v:
Bioconjug Chem
This paper describes how the ligand shell containing immunostimulatory oligonucleotides surrounding gold nanoparticles affects the in vitro activation of macrophages. Nanoconstructs with similar ligand densities but different oligonucleotide composit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fd585bdc88b3c93da0716c9162c03d
https://pubmed.ncbi.nlm.nih.gov/31243978
https://pubmed.ncbi.nlm.nih.gov/31243978
Publikováno v:
Advanced Drug Delivery Reviews. 99:12-27
The high concentration of mineral present in bone and pathological calcifications is unique compared with all other tissues and thus provides opportunity for targeted delivery of pharmaceutical drugs, including radiosensitizers and imaging probes. Ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c0b43f3ebacb2c495cbc0f87920e96
https://doi.org/10.1016/j.addr.2015.10.005
https://doi.org/10.1016/j.addr.2015.10.005
Publikováno v:
Acta biomaterialia. 82
A preclinical murine model of hydroxyapatite (HA) breast microcalcifications (µcals), which are an important clinical biomarker for breast cancer detection, was used to investigate the independent effects of high affinity bisphosphonate (BP) ligands
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a491f04e50b731c273438411e7062e3
https://pubmed.ncbi.nlm.nih.gov/30316022
https://pubmed.ncbi.nlm.nih.gov/30316022
Autor:
Rishi Lulla, Kristen L. Lauing, Lisa E. Cole, Alexander H. Stegh, Derek A. Wainwright, Lijie Zhai, Alicia Lenzen, Rintaro Hashizume, Erik Ladomersky
BACKGROUND: Research on adult high-grade gliomas has shown a targetable pathway through the inflammation-induced expression of indoleamine 2,3 dioxygenase (IDO1) and its recognized ability to suppress the anti-tumor immune response. Our project delin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71853115e7f252108b6730d71297fdb8
https://europepmc.org/articles/PMC6012849/
https://europepmc.org/articles/PMC6012849/
Autor:
Stacey N. Barnaby, Chad A. Mirkin, Jasmine L. May, Anthony J. Sprangers, Nikunjkumar Savalia, Alexander H. Stegh, Serena T. Ghelfi, Lisa E. Cole, Timothy L. Sita, Thomas C. Cayton, Timothy J. Merkel, Lisa A. Hurley, Andrew Lee, Fotini M. Kouri, Alexandra Chalastanis, Charles David James
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(16)
RNA interference (RNAi)-based gene regulation platforms have shown promise as a novel class of therapeutics for the precision treatment of cancer. Techniques in preclinical evaluation of RNAi-based nanoconjugates have yet to allow for optimization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b12fa6d29da5354b83d2715397f2d0
https://pubmed.ncbi.nlm.nih.gov/28373576
https://pubmed.ncbi.nlm.nih.gov/28373576
Autor:
Karen D. Cowden Dahl, Prakash D. Nallathamby, Lisa E. Irimata, Ryan K. Roeder, Lisa E. Cole, Tracie L. McGinnity, Tracy Vargo-Gogola, Tyler E. Curtis
Publikováno v:
Medical Imaging 2017: Physics of Medical Imaging.
Precision imaging is needed to realize precision medicine in cancer detection and treatment. Molecular imaging offers the ability to target and identify tumors, associated abnormalities, and specific cell populations with overexpressed receptors. Nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e192ddbd0910ad19482c9ac014a5dc7c
https://doi.org/10.1117/12.2255688
https://doi.org/10.1117/12.2255688