Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lisa E. Beebe"'
Publikováno v:
International Journal of Toxicology. 18:123-130
The dose-response relationships for hepatic cytochrome P450 (CYP) induction by 1,4-bis(2-[3,5-dichloropyridyloxy])benzene (TCPOBOP) were examined in the male B6C3F1 mouse. TCPOBOP, administered for 14 days at 0.393–96.2 ppm in the diet, caused conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7aa76af90c6a5915e01fbbabd644d52
https://doi.org/10.1080/109158199225693
https://doi.org/10.1080/109158199225693
Autor:
William L. Alworth, Laura W. Fornwald, Paul F. Hollenberg, Elizabeth S. Roberts, Lisa E. Beebe
Publikováno v:
Biochemical Pharmacology. 52:1507-1513
Suicide inhibitors of cytochrome P450 families are excellent tools to predict which isoforms mediate the metabolism/activation of a variety of chemical agents. We compared the inhibitory effects of several arylalkynes on mouse cytochromes P450 with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4c5101da71105cebdcc924a5a8e9a2
https://doi.org/10.1016/s0006-2952(96)00525-4
https://doi.org/10.1016/s0006-2952(96)00525-4
Publikováno v:
Chemico-Biological Interactions. 97:215-227
In this report, we have investigated the effect of dietary exposure to Aroclor 1254 (1-100 ppm) given chronically or discontinuously over an 84-day time interval to the female F344 rat. Cytochrome P4501A was quantified in lung and kidney by measuring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eeb4c990d37984088eff4798daeb4f8
https://doi.org/10.1016/0009-2797(95)03617-u
https://doi.org/10.1016/0009-2797(95)03617-u
Autor:
Yooson E. Kim, Lucy M. Anderson, Robert M. Kovatch, Shantu Amin, Lisa E. Beebe, Charles W. Riggs
Publikováno v:
Carcinogenesis. 14:1545-1548
We have previously shown a positive tumor-promoting effect of a single dose of Aroclor 1254 on lung and liver tumors initiated neonatally in the mouse by N-nitrosodimethylamine (NDMA). In this study, we have confirmed and extended this observation wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7c653b149947398bab3a25f8aba8954
https://doi.org/10.1093/carcin/14.8.1545
https://doi.org/10.1093/carcin/14.8.1545
Autor:
Collins R. Jones, Raymond W. Nims, Stephen D. Fox, Ronald A. Lubet, Paul E. Thomas, Haleem J. Issaq, Lisa E. Beebe, Konstantin H. Dragnev
Publikováno v:
Environmental Research. 59:447-466
Male F344/NCr rats were exposed to low dietary concentrations of Aroclor 1254 (0-33 ppm) for 7 days, following which the induction of selected hepatic drug metabolizing enzymes was monitored. CYP1A1, measured indirectly by assaying the O-dealkylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe17eda08a0192e085bd67e162c3051
https://doi.org/10.1016/s0013-9351(05)80048-9
https://doi.org/10.1016/s0013-9351(05)80048-9
Publikováno v:
Environmental Toxicology and Chemistry. 10:757-763
The polyhalogenated aromatic hydrocarbons (PHHs), consisting of the chlorinated and brominated biphenyls, dibenzo-p-dioxins and dibenzofurans, are important environmental contaminants affecting both wildlife and humans. Although the biological effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0351b29e844231446a7e4ce75d25edee
https://doi.org/10.1002/etc.5620100607
https://doi.org/10.1002/etc.5620100607
Publikováno v:
Environmental Toxicology and Chemistry. 10:681-690
Poorly metabolized polychlorinated biphenyl (PCB) congeners are bioaccumulated in the bodies of rodents and humans. Little is known about the continuing biological effects of these persistent chemicals. To determine whether a single high dose of a PC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::085a4729dc87176894e679a01e8ec3b3
https://doi.org/10.1002/etc.5620100514
https://doi.org/10.1002/etc.5620100514
Publikováno v:
Carcinogenesis. 16(6)
The environmental contaminant, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is highly toxic to several rodent species and may have adverse health effects in exposed human populations. Further, TCDD has been shown to be a potent liver tumor promoter in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe1b5e6404c89721d805d0858dfb5f9d
https://pubmed.ncbi.nlm.nih.gov/7788853
https://pubmed.ncbi.nlm.nih.gov/7788853
Autor:
Stephen D. Fox, Paul E. Thomas, Ronald A. Lubet, Lisa E. Beebe, Raymond W. Nims, Konstantin H. Dragnev, Collins R. Jones
Publikováno v:
Toxicology and applied pharmacology. 125(1)
Female F344/NCr rats were exposed continuously (7-84 days) or discontinuously (7 days exposure/21 days control diet or 28 days exposure/56 days control diet) to various dietary concentrations (1-100 ppm) of Aroclor 1254. There were dose- and time-dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34300b44cc402653d1a67a0903a97d1e
https://pubmed.ncbi.nlm.nih.gov/7510429
https://pubmed.ncbi.nlm.nih.gov/7510429
Autor:
Haleem J. Issaq, Sang S. Park, Charles W. Riggs, Harry V. Gelboin, Stephen D. Fox, Lucy M. Anderson, Lisa E. Beebe
Publikováno v:
Toxicology and applied pharmacology. 114(1)
The polychlorinated biphenyl mixture Aroclor 1254 has been shown to elicit prolonged biochemical responses in several rodent species, particularly induction of mixed function oxygenases in hepatic tissue. Lung is also of interest since a single dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8009446f0cb4f2b8971c724a6c1c7cc
https://pubmed.ncbi.nlm.nih.gov/1585368
https://pubmed.ncbi.nlm.nih.gov/1585368