Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Lisa E Gralinski"'
Autor:
Jessica B Graham, Jessica L Swarts, Sarah R Leist, Alexandra Schäfer, Vineet D Menachery, Lisa E Gralinski, Sophia Jeng, Darla R Miller, Michael A Mooney, Shannon K McWeeney, Martin T Ferris, Fernando Pardo-Manuel de Villena, Mark T Heise, Ralph S Baric, Jennifer M Lund
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009287 (2021)
The COVID-19 pandemic has revealed that infection with SARS-CoV-2 can result in a wide range of clinical outcomes in humans. An incomplete understanding of immune correlates of protection represents a major barrier to the design of vaccines and thera
Externí odkaz:
https://doaj.org/article/be424a125c6f47b582b6def18907ae94
Autor:
Lisa E Gralinski, Martin T Ferris, David L Aylor, Alan C Whitmore, Richard Green, Matthew B Frieman, Damon Deming, Vineet D Menachery, Darla R Miller, Ryan J Buus, Timothy A Bell, Gary A Churchill, David W Threadgill, Michael G Katze, Leonard McMillan, William Valdar, Mark T Heise, Fernando Pardo-Manuel de Villena, Ralph S Baric
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005504 (2015)
New systems genetics approaches are needed to rapidly identify host genes and genetic networks that regulate complex disease outcomes. Using genetically diverse animals from incipient lines of the Collaborative Cross mouse panel, we demonstrate a gre
Externí odkaz:
https://doaj.org/article/b8f7d6c3b6f74bfd8dd8a1fd634eea07
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0131451 (2015)
Viral pathogenesis studies in mice have relied on markers of severe systemic disease, rather than clinically relevant measures, to evaluate respiratory virus infection; thus confounding connections to human disease. Here, whole-body plethysmography w
Externí odkaz:
https://doaj.org/article/acd2f12ae97f41aaa1859639ca8c8e19
Publikováno v:
Frontiers in Genetics, Vol 4 (2014)
To better understand dynamic disease processes, integrated multi-omic methods are needed, yet comparing different types of omic data remains difficult. Integrative solutions benefit experimenters by eliminating potential biases that come with single
Externí odkaz:
https://doaj.org/article/60e9008d6b874cec8253ebb865085fdb
Autor:
Alexandra Schäfer, Lisa E. Gralinski, Sarah R. Leist, Brea K. Hampton, Michael A. Mooney, Kara L. Jensen, Rachel L. Graham, Sudhakar Agnihothram, Sophia Jeng, Steven Chamberlin, Timothy A. Bell, D. Trevor Scobey, Colton L. Linnertz, Laura A. VanBlargan, Larissa B. Thackray, Pablo Hock, Darla R. Miller, Ginger D. Shaw, Michael S. Diamond, Fernando Pardo Manuel de Villena, Shannon K. McWeeney, Mark T. Heise, Vineet D. Menachery, Martin T. Ferris, Ralph S. Baric
Publikováno v:
Virus Research, Vol 344, Iss , Pp 199357- (2024)
Coronavirus (CoV) cause considerable morbidity and mortality in humans and other mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in 2003, Middle East Respiratory CoV (MERS-CoV) in 2012, and SARS-CoV-2 in 2019. Althou
Externí odkaz:
https://doaj.org/article/b0e04c6b05a3457095b5a1d8a67680f6
Autor:
Martin T Ferris, David L Aylor, Daniel Bottomly, Alan C Whitmore, Lauri D Aicher, Timothy A Bell, Birgit Bradel-Tretheway, Janine T Bryan, Ryan J Buus, Lisa E Gralinski, Bart L Haagmans, Leonard McMillan, Darla R Miller, Elizabeth Rosenzweig, William Valdar, Jeremy Wang, Gary A Churchill, David W Threadgill, Shannon K McWeeney, Michael G Katze, Fernando Pardo-Manuel de Villena, Ralph S Baric, Mark T Heise
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003196 (2013)
Genetic variation contributes to host responses and outcomes following infection by influenza A virus or other viral infections. Yet narrow windows of disease symptoms and confounding environmental factors have made it difficult to identify polymorph
Externí odkaz:
https://doaj.org/article/7b65541d5dda41df84e78d9a797b012a
Autor:
Kenneth H. Dinnon, Sarah R. Leist, Kenichi Okuda, Hong Dang, Ethan J. Fritch, Kendra L. Gully, Gabriela De la Cruz, Mia D. Evangelista, Takanori Asakura, Rodney C. Gilmore, Padraig Hawkins, Satoko Nakano, Ande West, Alexandra Schäfer, Lisa E. Gralinski, Jamie L. Everman, Satria P. Sajuthi, Mark R. Zweigart, Stephanie Dong, Jennifer McBride, Michelle R. Cooley, Jesse B. Hines, Miriya K. Love, Steve D. Groshong, Alison VanSchoiack, Stefan J. Phelan, Yan Liang, Tyler Hether, Michael Leon, Ross E. Zumwalt, Lisa M. Barton, Eric J. Duval, Sanjay Mukhopadhyay, Edana Stroberg, Alain Borczuk, Leigh B. Thorne, Muthu K. Sakthivel, Yueh Z. Lee, James S. Hagood, Jason R. Mock, Max A. Seibold, Wanda K. O’Neal, Stephanie A. Montgomery, Richard C. Boucher, Ralph S. Baric
Publikováno v:
Science Translational Medicine. 14
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop post-acute sequelae of SARS-CoV-2 (PASC), but the mechanistic basis of PASC-associated lung abnormalities suffers from a lack of longitudinal tissue samples. The mou
Autor:
Alexandra Schäfer, Sarah R. Leist, Lisa E. Gralinski, David R. Martinez, Emma S. Winkler, Kenichi Okuda, Padraig E. Hawkins, Kendra L Gully, Rachel L. Graham, D. Trevor Scobey, Timothy A. Bell, Pablo Hock, Ginger D. Shaw, Jennifer F. Loome, Emily A. Madden, Elizabeth Anderson, Victoria K. Baxter, Sharon A. Taft-Benz, Mark R. Zweigart, Samantha R. May, Stephanie Dong, Matthew Clark, Darla R. Miller, Rachel M Lynch, Mark T. Heise, Roland Tisch, Richard C. Boucher, Fernando Pardo Manuel de Villena, Stephanie A. Montgomery, Michael S. Diamond, Martin T. Ferris, Ralph S. Baric
Publikováno v:
bioRxiv
Infectious diseases have shaped the human population genetic structure, and genetic variation influences the susceptibility to many viral diseases. However, a variety of challenges have made the implementation of traditional human Genome-wide Associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f56e99532e07c6b11bb5bb9e2b21a8
https://doi.org/10.1101/2022.06.01.494461
https://doi.org/10.1101/2022.06.01.494461
Autor:
Wan-ting He, Rami Musharrafieh, Ge Song, Katharina Dueker, Longping V. Tse, David R. Martinez, Alexandra Schäfer, Sean Callaghan, Peter Yong, Nathan Beutler, Jonathan L. Torres, Reid M. Volk, Panpan Zhou, Meng Yuan, Hejuni Liu, Fabio Anzanello, Tazio Capozzola, Mara Parren, Elijah Garcia, Stephen A. Rawlings, Davey M. Smith, Ian A. Wilson, Yana Safonova, Andrew B. Ward, Thomas F. Rogers, Ralph S. Baric, Lisa E. Gralinski, Dennis R. Burton, Raiees Andrabi
Publikováno v:
Nature immunology, vol 23, iss 6
Nat Immunol
bioRxiv
Nat Immunol
bioRxiv
SUMMARYThe emergence of current SARS-CoV-2 variants of concern (VOCs) and potential future spillovers of SARS-like coronaviruses into humans pose a major threat to human health and the global economy 1–7. Development of broadly effective coronaviru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cb30cf9d2ef8c64fbdbe66913c4bd3
https://escholarship.org/uc/item/1c37m2gx
https://escholarship.org/uc/item/1c37m2gx
Autor:
Kenneth H. Dinnon, Sarah R. Leist, Kenichi Okuda, Hong Dang, Ethan J. Fritch, Kendra L. Gully, Gabriela De la Cruz, Mia D. Evangelista, Takanori Asakura, Rodney C. Gilmore, Padraig Hawkins, Satoko Nakano, Ande West, Alexandra Schäfer, Lisa E. Gralinski, Jamie L. Everman, Satria P. Sajuthi, Mark R. Zweigart, Stephanie Dong, Jennifer McBride, Michelle R. Cooley, Jesse B. Hines, Miriya K. Love, Steve D. Groshong, Alison VanSchoiack, Stefan J. Phelan, Yan Liang, Tyler Hether, Michael Leon, Ross E. Zumwalt, Lisa M. Barton, Eric J. Duval, Sanjay Mukhopadhyay, Edana Stroberg, Alain Borczuk, Leigh B. Thorne, Muthu K. Sakthivel, Yueh Z. Lee, James S. Hagood, Jason R. Mock, Max A. Seibold, Wanda K. O’Neal, Stephanie A. Montgomery, Richard C. Boucher, Ralph S. Baric
Publikováno v:
bioRxiv : the preprint server for biology.
COVID-19 survivors develop post-acute sequelae of SARS-CoV-2 (PASC), but the mechanistic basis of PASC-associated lung abnormalities suffers from a lack of longitudinal samples. Mouse-adapted SARS-CoV-2 MA10 produces an acute respiratory distress syn