Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lisa Dwane"'
Autor:
Laoighse Mulrane, René Bernards, William M. Gallagher, Aisling O'Connor, Lisa Dwane, Brenton Cavanagh, Annette M.G. Dirac, Brian Mooney, Elspeth Ward, Benedikt M. Kessler, Anna M. Blümel, Adan Pinto-Fernandez, Karin Jirström, Triona Ni Chonghaile, Bruce Moran, Darran P. O'Connor, Sudipto Das
Publikováno v:
Cancer Research. 80:5076-5088
Approximately 70% of breast cancers express estrogen receptor α (ERα) and depend on this key transcriptional regulator for proliferation and differentiation. While patients with this disease can be treated with targeted antiendocrine agents, drug r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c574e185effc9574bd8dc1ce179332d2
https://doi.org/10.1158/0008-5472.can-20-0214
https://doi.org/10.1158/0008-5472.can-20-0214
Autor:
Lisa Dwane, Francesco Iorio, Howard Lightfoot, Wanjuan Yang, Mathew J. Garnett, Miguel Pignatelli, Emanuel Gonçalves, Rebecca Shepherd, Dieudonne van der Meer, Fiona M. Behan
Publikováno v:
Nucleic Acids Research
CRISPR genetic screens in cancer cell models are a powerful tool to elucidate oncogenic mechanisms and to identify promising therapeutic targets. The Project Score database (https://score.depmap.sanger.ac.uk/) uses genome-wide CRISPR–Cas9 dropout s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155d18294b44edb15808d22990f0f2ee
https://doi.org/10.1093/nar/gkaa882
https://doi.org/10.1093/nar/gkaa882
Autor:
Patricia Jaaks, Elizabeth A. Coker, Daniel J. Vis, Olivia Edwards, Emma F. Carpenter, Simonetta M. Leto, Lisa Dwane, Francesco Sassi, Howard Lightfoot, Syd Barthorpe, Dieudonne van der Meer, Wanjuan Yang, Alexandra Beck, Tatiana Mironenko, Caitlin Hall, James Hall, Iman Mali, Laura Richardson, Charlotte Tolley, James Morris, Frances Thomas, Ermira Lleshi, Nanne Aben, Cyril H. Benes, Andrea Bertotti, Livio Trusolino, Lodewyk Wessels, Mathew J. Garnett
Publikováno v:
NATURE
Nature: international weekly journal of science, 603(7899)
Nature: international weekly journal of science, 603(7899)
Combinations of anti-cancer drugs can overcome resistance and provide new treatments1,2. The number of possible drug combinations vastly exceeds what could be tested clinically. Efforts to systematically identify active combinations and the tissues a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fc1884fa3d13b5a34231b13ffdc860
https://pubmed.ncbi.nlm.nih.gov/35197630
https://pubmed.ncbi.nlm.nih.gov/35197630
Autor:
Lisa Dwane, René Bernards, Sudipto Das, Aisling O'Connor, Laoighse Mulrane, Darran P. O'Connor, Annette M.G. Dirac, T Ni Chonghaile, Bruce Moran, W. M. Gallagher, John Crown, Karin Jirström
Publikováno v:
Cancer Research. 78:P2-05
Approximately 70% of breast cancers overexpress the estrogen receptor α (ERα) and depend on this key transcriptional regulator for growth and differentiation. The discovery of novel mechanisms controlling ERα function represent major advances in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4d56ca2586b573d2a575a01395265c
https://doi.org/10.1158/1538-7445.sabcs17-p2-05-02
https://doi.org/10.1158/1538-7445.sabcs17-p2-05-02
The addition of ubiquitin to a target protein has long been implicated in the process of degradation and is the primary mediator of protein turnover in the cell. Recently, however, many non-proteolytic functions of ubiquitination have emerged as key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10ad159e1afd72d30d149c6af1e8711
https://europepmc.org/articles/PMC5339741/
https://europepmc.org/articles/PMC5339741/
Autor:
Laoighse Mulrane, René Bernards, Aisling O'Connor, T Ni Chonghaile, Lisa Dwane, William M. Gallagher, Darran P. O'Connor, Bruce Moran, Karin Jirström, Sudipto Das
Publikováno v:
ESMO Open. 3:A157
Introduction Approximately 80% of breast cancers overexpress the oestrogen receptor α (ERα) and depend on this key transcriptional regulator for growth. The discovery of novel mechanisms controlling ERα function represent major advances in our und
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba5020d7f185694aee9ba5c9f518f098
https://doi.org/10.1136/esmoopen-2018-eacr25.375
https://doi.org/10.1136/esmoopen-2018-eacr25.375
Autor:
Lisa Dwane, René Bernards, Darran P. O'Connor, John Crown, Aisling O'Connor, Annette M.G. Dirac, Laoighse Mulrane, Karin Jirström, Triona Ni Chonghaile, William M. Gallagher
Publikováno v:
Cancer Research. 77:3040-3040
Approximately 70% of breast cancers overexpress the estrogen receptor α (ERα) and depend on this key transcriptional regulator for growth and differentiation. The discovery of novel mechanisms controlling ERα function represent major advances in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::920f971fa0a55ae292c7ca35b9e4c839
https://doi.org/10.1158/1538-7445.am2017-3040
https://doi.org/10.1158/1538-7445.am2017-3040
Publikováno v:
Cancer Research. 76:LB-104
The estrogen receptor (ER) is the principal driver of growth and differentiation in breast cells and de-regulated receptor function is a key feature of almost 75% of breast cancers. Here, we investigated the role of de-ubiquitinating enzymes (DUBs),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5247667066ebee151395f23416ca2391
https://doi.org/10.1158/1538-7445.am2016-lb-104
https://doi.org/10.1158/1538-7445.am2016-lb-104
Autor:
Rut Klinger, K. Jirstrom, Darran P. O'Connor, L. Mulrane, John Crown, René Bernards, W. M. Gallagher, Aisling O'Connor, A. Dirac, Lisa Dwane
Publikováno v:
European Journal of Cancer. 61:S10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c144bf5165c9ddaa590206d102ed8cfb
https://doi.org/10.1016/s0959-8049(16)61022-5
https://doi.org/10.1016/s0959-8049(16)61022-5
Publikováno v:
Journal of Clinical Oncology. 34:e12048-e12048
e12048Background: The estrogen receptor (ER) is the principal driver of growth in breast cells and de-regulated receptor function is a key feature of ~75% of breast cancers. Here, we investigated the role of deubiquitinating enzymes (DUBs) in regulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e0aac8e2b7b342c54b57c73056f6c11
https://doi.org/10.1200/jco.2016.34.15_suppl.e12048
https://doi.org/10.1200/jco.2016.34.15_suppl.e12048