Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lisa Dreolini"'
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-16 (2023)
Abstract Background Sequence verification is essential for plasmids used as critical reagents or therapeutic products. Typically, high-quality plasmid sequence is achieved through capillary-based Sanger sequencing, requiring customized sets of primer
Externí odkaz:
https://doaj.org/article/dc10f57d9bd44154b770c27724b9f67e
Autor:
Craig M. Rive, Eric Yung, Lisa Dreolini, Scott D. Brown, Christopher G. May, Daniel J. Woodsworth, Robert A. Holt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 4-14 (2022)
Anti-CD19 chimeric antigen receptor (CAR)-T therapy for B cell malignancies has shown clinical success, but a major limitation is the logistical complexity and high cost of manufacturing autologous cell products. If engineered for improved safety, di
Externí odkaz:
https://doaj.org/article/e9e2841271204775972c31c9bc2c6647
Autor:
Natasha Kekre, Kevin A. Hay, John R. Webb, Ranjeeta Mallick, Miruna Balasundaram, Mhairi K. Sigrist, Anne-Marie Clement, Julie S. Nielsen, Jennifer Quizi, Eric Yung, Scott D. Brown, Lisa Dreolini, Daniel D. Waller, Julian Smazynski, Nicole S. Gierc, Bianca C. Loveless, Kayla Clark, Tyler Dyer, Richard Hogg, Leah McCormick, Michael Gignac, Shanti Bell, D. Maria Chapman, David Bond, Siao Yong, Rachel Fung, Heather M. Lockyer, Victoria Hodgson, Catherine Murphy, Ana Subramanian, Evelyn Wiebe, Piriya Yoganathan, Liana Medynski, Dominique C. Vaillan, Alice Black, Sheryl McDiarmid, Michael Kennah, Linda Hamelin, Kevin Song, Sujaatha Narayanan, Judith A. Rodrigo, Stefany Dupont, Terry Hawrysh, Justin Presseau, Kednapa Thavorn, Manoj M. Lalu, Dean A. Fergusson, John C. Bell, Harold Atkins, Brad H. Nelson, Robert A. Holt
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Access to commercial CD19 CAR-T cells remains limited even in wealthy countries like Canada due to clinical, logistical, and financial barriers related to centrally manufactured products. We created a non-commercial academic platform for end-to-end m
Externí odkaz:
https://doaj.org/article/ba9bb5ccb69a4646aee78f29aa8e0137
Autor:
Lisa Dreolini, Mark Cullen, Eric Yung, Lawrence Laird, John R. Webb, Brad H. Nelson, Kevin A. Hay, Miruna Balasundaram, Natasha Kekre, Robert A. Holt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss , Pp 393-399 (2020)
Mycoplasma species (spp.) bacteria can infect cell cultures, posing a potential threat to recipients of cell therapy products. Conventional Mycoplasma testing methods are highly sensitive but typically require a minimum of 28 days to produce results.
Externí odkaz:
https://doaj.org/article/999a6fbd36cd41d6b988f524b73f3d75
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 7, Iss C, Pp 132-145 (2017)
There is great potential for engineering cellular therapeutics by repurposing biological systems. Here, we report utilization of the granzyme-perforin pathway of cytotoxic lymphocytes as a cell-to-cell protein delivery module. We designed and constru
Externí odkaz:
https://doaj.org/article/f2dfc719feb147179d410577cf0eb40a
Autor:
Miruna Balasundaram, John R. Webb, Lisa Dreolini, Brad H. Nelson, Natasha Kekre, Kevin A. Hay, Eric Yung, Lawrence Laird, Mark Cullen, Robert A. Holt
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 17, Iss, Pp 393-399 (2020)
Mycoplasma species (spp.) bacteria can infect cell cultures, posing a potential threat to recipients of cell therapy products. Conventional Mycoplasma testing methods are highly sensitive but typically require a minimum of 28 days to produce results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea09bd1e6b9f3d6a71e04b999b36d8fe
https://doi.org/10.1016/j.omtm.2020.01.009
https://doi.org/10.1016/j.omtm.2020.01.009
Autor:
Lisa Dreolini, Oliver Baker, Robert A. Holt, Jan M. Deussing, Chin-Vern Tan, Anthony Mathelier, Wyeth W. Wasserman, Jack W. Hickmott, A. Francis Stewart, Claudia Kuehne, Russell J. Bonaguro, Michelle Zhou, Elizabeth M. Simpson, Siu Ling Lam, Jillian Smith, Andrea J. Korecki, Dan Goldowitz
Publikováno v:
Genetics
To understand gene function, the cre/loxP conditional system is the most powerful available for temporal and spatial control of expression in mouse. However, the research community requires more cre recombinase expressing transgenic mouse strains (cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afcd0bd1185075d280624d22144ab5e
https://doi.org/10.1534/genetics.119.301984
https://doi.org/10.1534/genetics.119.301984
Autor:
Cassia Warren, Donald T. T. Yapp, Jonathan M. Loree, Joanna M. Karasinska, Gregg B. Morin, Lisa Dreolini, Nasrin M. Mawji, Govinda Sharma, Simon Turcotte, David F. Schaeffer, Craig M. Rive, Christopher S. Hughes, Scott D. Brown, Robert A. Holt, Eric Yung, Daniel J. Renouf
KRAS codon 12 mutations are among the most common hotspot mutations in human cancer. Using a functional screening platform we set out to identify αβ T-cell receptors (TCRs) as potential targeting reagents for KRASG12D and/or KRASG12V neoepitopes pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::046c518d290d70f93ca1f17e5648abed
https://doi.org/10.1101/2020.06.15.149021
https://doi.org/10.1101/2020.06.15.149021
Autor:
Craig M. Rive, Eric Yung, Lisa Dreolini, Scott D. Brown, Christopher G. May, Daniel J. Woodsworth, Robert A. Holt
Anti-CD19 CAR-T therapy for B cell malignancies has shown clinical success, but a major limitation is the logistical complexity and high cost of manufacturing autologous cell products. If engineered for improved safety, direct infusion of viral gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0267434bf3520502a69a06916037901d
https://doi.org/10.1101/2020.05.15.098335
https://doi.org/10.1101/2020.05.15.098335
Autor:
Lisa, Dreolini, Mark, Cullen, Eric, Yung, Lawrence, Laird, John R, Webb, Brad H, Nelson, Kevin A, Hay, Miruna, Balasundaram, Natasha, Kekre, Robert A, Holt
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Mycoplasma species (spp.) bacteria can infect cell cultures, posing a potential threat to recipients of cell therapy products. Conventional Mycoplasma testing methods are highly sensitive but typically require a minimum of 28 days to produce results.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0c4970946aa02f51d7612f5c0bfbab3
https://pubmed.ncbi.nlm.nih.gov/32128343
https://pubmed.ncbi.nlm.nih.gov/32128343