Structure of the Neisseria meningitidis Type IV pilus

Autor: Subramania Kolappan, Mathieu Coureuil, Xiong Yu, Xavier Nassif, Edward H. Egelman, Lisa Craig

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)

Type IV pili are present on a wide range of bacterial pathogens and mediate diverse functions. Here the authors report a high resolution crystal structure of the pilin subunit PilE, and a cryoEM reconstruction of the Type IV pilus filament from N. me

Externí odkaz: https://doaj.org/article/39246ee32583442596e6d29879d5c289

The Vibrio cholerae Minor Pilin TcpB Initiates Assembly and Retraction of the Toxin-Coregulated Pilus.

Autor: Dixon Ng, Tony Harn, Tuba Altindal, Subramania Kolappan, Jarrad M Marles, Rajan Lala, Ingrid Spielman, Yang Gao, Caitlyn A Hauke, Gabriela Kovacikova, Zia Verjee, Ronald K Taylor, Nicolas Biais, Lisa Craig

Publikováno v: PLoS Pathogens, Vol 12, Iss 12, p e1006109 (2016)

Type IV pilus (T4P) systems are complex molecular machines that polymerize major pilin proteins into thin filaments displayed on bacterial surfaces. Pilus functions require rapid extension and depolymerization of the pilus, powered by the assembly an

Externí odkaz: https://doaj.org/article/2e894c7d3bd745529e05024500501eea

Mechanism of secretion of TcpF by the Vibrio cholerae toxin-coregulated pilus

Autor: Minh Nguyen, Tzu-Hui Wu, Katie J. Danielson, Nabeel M. Khan, John Zhijia Zhang, Lisa Craig

Publikováno v: Proceedings of the National Academy of Sciences. 120

Many bacteria possess dynamic filaments called Type IV pili (T4P) that perform diverse functions in colonization and dissemination, including host cell adhesion, DNA uptake, and secretion of protein substrates—exoproteins—from the periplasm to th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79d6e5dc7f777bd891b6358887101e8e
https://doi.org/10.1073/pnas.2212664120

Motor-independent retraction of type IV pili is governed by an inherent property of the pilus filament

Autor: Jennifer L. Chlebek, Rémi Denise, Ankur B. Dalia, Lisa Craig

Publikováno v: Proc Natl Acad Sci U S A

Type IV pili (T4P) are dynamic surface appendages that promote virulence, biofilm formation, horizontal gene transfer, and motility in diverse bacterial species. Pilus dynamic activity is best characterized in T4P that use distinct ATPase motors for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8c7f5be08f7d66d296261882de8a01
https://europepmc.org/articles/PMC8617508/

The minor pilin PilV provides a conserved adhesion site throughout the antigenically variable meningococcal type IV pilus

Autor: Philippe Morand, Lisa Craig, Subramania Kolappan, Marion Dupuis, Jean-Philippe Barnier, Haniaa Bouzinba-Segard, Julie Meyer, Emmanuelle Bille, Taliah Schmitt, Eric Frapy, Elena Capel, Gaël Gesbert, Sophia Schönherr-Hellec, Anne Jamet, Sandrine Bourdoulous, Xavier Nassif, Zoé Virion, Mathieu Coureuil

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (45), pp.e2109364118. ⟨10.1073/pnas.2109364118⟩

International audience; Neisseria meningitidis utilizes type IV pili (T4P) to adhere to and colonize host endothelial cells, a process at the heart of meningococcal invasive diseases leading to meningitis and sepsis. T4P are polymers of an antigenica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380344cc6b67faa3a165f2f12f1676c1
https://pubmed.ncbi.nlm.nih.gov/34725157