Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lisa Connell-Crowley"'
Autor:
Steven Rose, Sevda Deldari, Maen Qadan, Lisa Connell-Crowley, Jonathan Coffman, Ujwal Patil, David Pollard, Joseph Shultz, Brian Horowski, Mark Brower, Suzanne S. Farid, Eugene Schaefer
Publikováno v:
Biotechnology and Bioengineering
There is a growing application of integrated and continuous bioprocessing (ICB) for manufacturing recombinant protein therapeutics produced from mammalian cells. At first glance, the newly evolved ICB has created a vast diversity of platforms. A clos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32befb98dd82bafe0ddbcbb014200010
http://europepmc.org/articles/PMC8248397
http://europepmc.org/articles/PMC8248397
Autor:
Lisa Connell-Crowley, Kelley C. Rogers, Allison Haug, Eric Fallon, David Pollard, Mark Brower, Maen Qadan, Jason Walther, Ciaran Brady, Timothy S. Charlebois, Michael Coolbaugh, Christopher Gillespie, Kelvin H. Lee, Ruben G. Carbonell, Gene Schaefer, Jeffrey Baker, Roger Hart, Michael A. Phillips, John Erickson, Jon Coffman, Irina Ramos, Eric Garr, Shawn Barrett, Gregg Nyberg
Publikováno v:
Biotechnology and Bioengineering
An ambitious 10‐year collaborative program is described to invent, design, demonstrate, and support commercialization of integrated biopharmaceutical manufacturing technology intended to transform the industry. Our goal is to enable improved contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98ba4298af0d2a639f521f0bd8c493b
https://pubmed.ncbi.nlm.nih.gov/33480041
https://pubmed.ncbi.nlm.nih.gov/33480041
Publikováno v:
Development of Biopharmaceutical Drug-Device Products ISBN: 9783030314149
Multi-attribute method (MAM) is a mass spectrometry (MS)-based method that is used to directly characterize and monitor many product quality attributes and impurities on biotherapeutics. MAM utilizes high-resolution/accurate mass MS data. These data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5f818da71e97be6a564daa6f2aec193
https://doi.org/10.1007/978-3-030-31415-6_9
https://doi.org/10.1007/978-3-030-31415-6_9
Publikováno v:
Biotechnology Progress. 32:89-97
To ensure the viral safety of protein therapeutics made in mammalian cells, purification processes include dedicated viral clearance steps to remove or inactivate adventitious and endogenous viruses. One such dedicated step is low pH treatment, a rob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e085d6ace92746ffe418ab135c15de6a
https://doi.org/10.1002/btpr.2183
https://doi.org/10.1002/btpr.2183
Autor:
Lisa Connell-Crowley, Julia Bach
Publikováno v:
Biotechnology and Bioengineering. 112:743-750
Protein A chromatography is the most common unit operation used in the manufacture of therapeutic monoclonal antibodies (mAbs) due to its high affinity and specificity for the IgG Fc domain. However, protein A chromatography is often not effective fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d9a22e474529c1484eba3dcc973e4e
https://doi.org/10.1002/bit.25484
https://doi.org/10.1002/bit.25484
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 68:90-97
Biopharmaceutical processes typically incorporate a dedicated procedure to inactivate retroviruses and other enveloped viruses susceptible to inactivation. A common inactivation procedure is low-pH hold, in which the product pool is titrated to pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be731d9e4eab2f5da70601a3ea5bd6a
https://doi.org/10.5731/pdajpst.2014.00969
https://doi.org/10.5731/pdajpst.2014.00969
Autor:
Kiyoshi Fujimori, Nathan E. Lewis, Julia Bach, Ron Gillespie, Rebecca E. Mccoy, Kenneth M. Prentice, Catherine M. Eakin, Lisa Connell-Crowley
Publikováno v:
mAbs. 5:974-981
Process control of protein therapeutic manufacturing is central to ensuring the product is both safe and efficacious for patients. In this work, we investigate the cause of pink color variability in development lots of monoclonal antibody (mAb) and F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2c6d06ecfccf38cc4d1f777e1d5e4a
https://doi.org/10.4161/mabs.25921
https://doi.org/10.4161/mabs.25921
Autor:
Dan Leiske, Nathaniel Lewis, Ron Gillespie, Jyoti Velayudhan, Lisa Connell-Crowley, Danielle Pace, Amanda Rohrbach, Tina Wu
Publikováno v:
Biotechnology progress. 32(5)
N-linked Fc glycosylation of IgG1 monoclonal antibody therapeutics can directly influence their mechanism of action by impacting IgG effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::399006520cb58c0a5f7fa781ad0912e6
https://pubmed.ncbi.nlm.nih.gov/27160519
https://pubmed.ncbi.nlm.nih.gov/27160519
Autor:
Houman Bashiri, Ron Gillespie, Houman Dehghani, Shivanthi Chinniah, Peter Hinckley, Lisa Connell-Crowley, Thao Nguyen, Julia Bach, Suresh Vunnum, John Moscariello, Ganesh Vedantham
Publikováno v:
Biotechnology and Bioengineering. 109:157-165
One measure taken to ensure safety of biotherapeutics produced in mammalian cells is to demonstrate the clearance of potential viral contaminants by downstream purification processes. This paper provides evidence that cation exchange chromatography (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b904deda0879e197b5a8ae0446ebdea
https://doi.org/10.1002/bit.23300
https://doi.org/10.1002/bit.23300
Autor:
Lisa Connell-Crowley, Michael J. Treuheit, Egor Trilisky, Brian D. Follstad, Paul D. Schnier, Randy Jensen, Jennifer Kerr, Matt Leith, Suresh Vunnum, Alison Wallace, John F. Valliere-Douglass, Alain Balland, Nathan E. Lewis
Publikováno v:
Protein Science. 19:2152-2163
Novel acetone and aldimine covalent adducts were identified on the N-termini and lysine side chains of recombinant monoclonal antibodies. Photochemical degradation of citrate buffers, in the presence of trace levels of iron, is demonstrated as the so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd6809d68b2d5d5560c5500afaa96e9
https://doi.org/10.1002/pro.495
https://doi.org/10.1002/pro.495