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866 RBN-2397, a novel, potent, and selective PARP7 inhibitor, induces tumor-intrinsic type I interferon responses and adaptive immunity in preclinical models and patient tumors

Autor: Chang Liu, Manish Patel, Gerald Falchook, Patricia LoRusso, Timothy Yap, Melissa Johnson, Kristy Kuplast-Barr, Ryan Abo, Erika Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/c69f81a7d6be48219521485df3d41f01

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866 RBN-2397, a novel, potent, and selective PARP7 inhibitor, induces tumor-intrinsic type I interferon responses and adaptive immunity in preclinical models and patient tumors

Autor: Kristy Kuplast-Barr, Melissa Johnson, Manish Patel, Timothy Yap, Gerald Falchook, Patricia LoRusso, Ryan Abo, Chang Liu, Erika Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundPARP7 is a mono-ART that is upregulated in response to cellular stress (e.g., viral infection, cigarette smoke), and suppresses the Type I interferon (IFN) response following cytosolic nucleic acid sensing. RBN-2397 is a first-in-class PARP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc7fe6a3608347c8b3043c4e29db724
https://doaj.org/article/c69f81a7d6be48219521485df3d41f01

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Abstract 1836: RBN-2397, a novel, potent, and selective PARP7 inhibitor, induces tumor-intrinsic type I interferon responses and adaptive immunity in patient tumors

Autor: Kristy Kuplast-Barr, Melissa L. Johnson, Manish R. Patel, Timothy A. Yap, Gerald S. Falchook, Patricia LoRusso, Ryan Abo, Chang Liu, Erika L. Manyak, Lisa Cleary, Viviana Bozon, Sudha Parasuraman, Heike Keilhack, Kristen McEachern

Publikováno v: Cancer Research. 82:1836-1836

Background: PARP7 is a mono-ART that is upregulated in response to cellular stress (e.g., viral infection, cigarette smoke), and suppresses the Type I interferon (IFN) response following cytosolic nucleic acid sensing. RBN-2397 is a first-in-class PA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7e458d842d50569df36c0e5f2a68521
https://doi.org/10.1158/1538-7445.am2022-1836

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