Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Autor: Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner

Publikováno v: Clinical and Translational Medicine, Vol 12, Iss 12, Pp n/a-n/a (2022)

Abstract Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases. Thermogenes

Externí odkaz: https://doaj.org/article/3c0531ab79ab4ae08f8a1517269c74c9

MicroRNAs and histone deacetylase inhibition-mediated protection against inflammatory β-cell damage.

Autor: Anna Lindeløv Vestergaard, Claus Heiner Bang-Berthelsen, Tina Fløyel, Jonathan Lucien Stahl, Lisa Christen, Farzaneh Taheri Sotudeh, Peter de Hemmer Horskjær, Klaus Stensgaard Frederiksen, Frida Greek Kofod, Christine Bruun, Lukas Adrian Berchtold, Joachim Størling, Romano Regazzi, Simranjeet Kaur, Flemming Pociot, Thomas Mandrup-Poulsen

Publikováno v: PLoS ONE, Vol 13, Iss 9, p e0203713 (2018)

Inflammatory β-cell failure contributes to type 1 and type 2 diabetes pathogenesis. Pro-inflammatory cytokines cause β-cell dysfunction and apoptosis, and lysine deacetylase inhibitors (KDACi) prevent β-cell failure in vitro and in vivo, in part b

Externí odkaz: https://doaj.org/article/75747a3581644861a7f4b25611226e34

Myoglobin reguliert die mitochondriale Atmungskapazität in braunen Adipozyten (#51)

Autor: Lisa Christen, Helen Broghammer, Inka Rapöhn, John T Heiker, Juliane Weiner

Publikováno v: Abstracts des Adipositas-Kongresses 2022 zur 38. Jahrestagung der Deutschen Adipositas Gesellschaft e.V. DAG.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1da615cafda97b64519bab501db97e6a
https://doi.org/10.1055/s-0042-1755679

Pathways for Theory Development: A Logic and a Methodology for Public and Nonprofit Strategic Planning

Autor: Gajary, Lisa Christen

Strategic planning ranks as one of the most popular management tools in public and nonprofit organizations and at all levels of government. However, fundamental questions remain unanswered. To both organize and advance empirical research, some promin

Externí odkaz: http://rave.ohiolink.edu/etdc/view?acc_num=osu1610089735227696

Mitophagy protects beta cells from inflammatory damage in diabetes

Autor: John A. Corbett, Emma C. Reck, Scott A. Soleimanpour, Biaoxin Chai, Morgan A. Gingerich, Benjamin Thompson, Lisa Christen, Thomas Mandrup-Poulsen, Vishal S. Parekh, Gemma L. Pearson, Vaibhav Sidarala, Leslie S. Satin, Jianhua Ren, Jie Zhu, Tracy Stromer

Publikováno v: JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
Sidarala, V, Pearson, G L, Parekh, V S, Thompson, B, Christen, L, Gingerich, M A, Zhu, J, Stromer, T, Ren, J, Reck, E C, Chai, B, Corbett, J A, Mandrup-Poulsen, T, Satin, L S & Soleimanpour, S A 2020, ' Mitophagy protects beta cells from inflammatory damage in diabetes ', JCI insight, vol. 5, no. 24, 141138 . https://doi.org/10.1172/jci.insight.141138

Inflammatory damage contributes to β-cell failure in type 1 and 2 diabetes (T1D and T2D). Mitochondria are damaged by inflammatory signaling in β-cells, resulting in impaired bioenergetics and initiation of pro-apoptotic machinery. Hence, the ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95489b3a754e5976312f493596ac093
https://doi.org/10.1101/2020.06.07.138917