Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Lisa Choy"'
Autor:
Christian W. Siebel, Matthew J. Brauer, Rayna Venook, Amy Shelton, David Finkle, Dorothy French, Margaret Solon, Thijs J. Hagenbeek, Lisa Choy
Gene lists related to Fig. 6E. Y axis = DAPT vs. DMSO. (Y-axis only; X-axis genes same as in Fig. 6D).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb0c3aa340489261fdd29f5bf3cc426
https://doi.org/10.1158/0008-5472.22416831
https://doi.org/10.1158/0008-5472.22416831
Autor:
Christian W. Siebel, Matthew J. Brauer, Rayna Venook, Amy Shelton, David Finkle, Dorothy French, Margaret Solon, Thijs J. Hagenbeek, Lisa Choy
Legends for figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8406679df72fbacc19da4cda2aa4fb
https://doi.org/10.1158/0008-5472.22416846
https://doi.org/10.1158/0008-5472.22416846
Autor:
Christian W. Siebel, Matthew J. Brauer, Rayna Venook, Amy Shelton, David Finkle, Dorothy French, Margaret Solon, Thijs J. Hagenbeek, Lisa Choy
Notch ligands signal through one of four receptors on neighboring cells to mediate cell–cell communication and control cell fate, proliferation, and survival. Although aberrant Notch activation has been implicated in numerous malignancies, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1793b7360f376a0e570e3ee9f0724eea
https://doi.org/10.1158/0008-5472.c.6509661
https://doi.org/10.1158/0008-5472.c.6509661
Autor:
Christian W. Siebel, Matthew J. Brauer, Rayna Venook, Amy Shelton, David Finkle, Dorothy French, Margaret Solon, Thijs J. Hagenbeek, Lisa Choy
Supplementary Figures 1-3 Supplementary Figure 1. NOTCH3 schematic (not to scale) showing residues for the furin (S1), metalloprotease (S2) and gamma-secretase (S3) cleavages. HD, heterodimerization; TM, transmembrane. Human S3 cleavage regions for N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21566eaa32ab6d2894aa8d2f56ca195
https://doi.org/10.1158/0008-5472.22416843.v1
https://doi.org/10.1158/0008-5472.22416843.v1
Autor:
Amy L. Shelton, Matthew J. Brauer, Rayna Venook, David Finkle, Christian W. Siebel, Thijs J. Hagenbeek, Dorothy French, Lisa Choy, Margaret Solon
Publikováno v:
Cancer Research. 77:1439-1452
Notch ligands signal through one of four receptors on neighboring cells to mediate cell–cell communication and control cell fate, proliferation, and survival. Although aberrant Notch activation has been implicated in numerous malignancies, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c627b6603f4c524ce50c4619262666
https://doi.org/10.1158/0008-5472.can-16-1022
https://doi.org/10.1158/0008-5472.can-16-1022
Autor:
Thijs J. Hagenbeek, Jeremy Stinson, Xiumin Wu, Cheryll Sanchez-Irizarry, Hergen Spits, Lisa Choy, Christian W. Siebel, Somasekar Seshagiri
Publikováno v:
Cancer letters, 346(2), 237-248. Elsevier Ireland Ltd
T cell acute lymphoblastic leukemias (T-ALLs) commonly display constitutively active PI3K/mTOR and Notch signaling. However, controversy surrounds whether these pathways have independent functions and whether Pten loss is sufficient to generate resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c58a49b4bc0d068f5a974ab379304d1
https://doi.org/10.1016/j.canlet.2013.12.027
https://doi.org/10.1016/j.canlet.2013.12.027
Autor:
Jiping Zha, Carol Cain-Hom, Sarah G. Hymowitz, Dorreyah Schahin-Reed, Yongmei Chen, Ryan J. Watts, Robert Choy, Amy L. Shelton, Gladys P. de Leon, Christopher A. Callahan, David Finkle, Jeff Zhang, Xiumin Wu, Rayna Venook, Minhong Yan, Christian W. Siebel, Lisa C. Kadyk, Graham J. Dow, Scott Stawicki, Thijs J. Hagenbeek, John B. Ridgway, Lisa Choy, Yan Wu, Peter Howard
Publikováno v:
Nature. 464:1052-1057
The four receptors of the Notch family are widely expressed transmembrane proteins that function as key conduits through which mammalian cells communicate to regulate cell fate and growth. Ligand binding triggers a conformational change in the recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88944dd678d7f8226390854f8afedbb8
https://doi.org/10.1038/nature08878
https://doi.org/10.1038/nature08878
Publikováno v:
The EMBO Journal. 28:88-98
During the course of breast cancer progression, normally dormant tumour-promoting effects of transforming growth factor beta (TGFbeta), including migration, invasion, and metastasis are unmasked. In an effort to identify mechanisms that regulate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b6a371cae343c17a699572550c7bfe
https://doi.org/10.1038/emboj.2008.266
https://doi.org/10.1038/emboj.2008.266
Autor:
Lisa Choy, Gregoire Pau, Jed Ross, Li Che, Xin Chen, Kathy Hötzel, Erik Huntzicker, Christian W. Siebel, Neeraj Sharma, Dorothy French
Publikováno v:
Hepatology (Baltimore, Md.), vol 61, iss 3
UnlabelledPrimary liver cancer encompasses both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). The Notch signaling pathway, known to be important for the proper development of liver architecture, is also a potential driver of primary li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60349a2b52f28a0ea47b51377b6d8b5
https://escholarship.org/uc/item/73k7g7j2
https://escholarship.org/uc/item/73k7g7j2
Publikováno v:
The Journal of Cell Biology
TGF-beta inhibits adipocyte differentiation, yet is expressed by adipocytes. The function of TGF-beta in adipogenesis, and its mechanism of action, is unknown. To address the role of TGF-beta signaling in adipocyte differentiation, we characterized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c136221d19865287f9db5782262ece
https://doi.org/10.1083/jcb.149.3.667
https://doi.org/10.1083/jcb.149.3.667