Tumor cells express pauci- and oligomannosidic N-glycans in glycoproteins recognized by the mannose receptor (CD206)

Autor: Lisa C. Laan, Chao Gao, Akul Y. Mehta, Kathrin Stavenhagen, Jonathan N. Glickman, Richard D. Cummings, Irma van Die, Jamie Heimburg-Molinaro

Publikováno v: Stavenhagen, K, Laan, L C, Gao, C, Mehta, A Y, Heimburg-Molinaro, J, Glickman, J N, van Die, I & Cummings, R D 2021, ' Tumor cells express pauci-and oligomannosidic N-glycans in glycoproteins recognized by the mannose receptor (CD206) ', Cellular and Molecular Life Sciences, vol. 78, no. 14, pp. 5569-5585 . https://doi.org/10.1007/s00018-021-03863-1
Cellular and Molecular Life Sciences, 78(14), 5569-5585. Birkhauser Verlag Basel

The macrophage mannose receptor (CD206, MR) is an endocytic lectin receptor which plays an important role in homeostasis and innate immunity, however, the endogenous glycan and glycoprotein ligands recognized by its C-type lectin domains (CTLD) have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794bd18b856c94c99f7a9a4d8355954d
https://doi.org/10.1007/s00018-021-03863-1

Pleurotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation

Autor: Lisa C. Laan, Masashi Mizuno, Irma van Die, Ken-ichiro Minato

Publikováno v: Minato, K, Laan, L C, van Die, I & Mizuno, M 2019, ' Pleurotus citrinopileatus polysaccharide stimulates anti-inflammatory properties during monocyte-to-macrophage differentiation ', International Journal of Biological Macromolecules, vol. 122, pp. 705-712 . https://doi.org/10.1016/j.ijbiomac.2018.10.157
International Journal of Biological Macromolecules, 122, 705-712. Elsevier

Polysaccharides from edible mushrooms possess important immunomodulating effects on immune cells including monocytes and macrophages. Macrophages activated by LPS/IFNγ are polarized toward inflammatory macrophages, whereas the anti-inflammatory prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe27606a7031c361b35eb2b63a420aa
https://doi.org/10.1016/j.ijbiomac.2018.10.157

Differential O- and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior

Autor: Jing Zhang, Peter ten Dijke, Ana I. Belo, Sandra J. van Vliet, Irma van Die, Tao Zhang, Lisa C. Laan, Boris Tefsen, Manfred Wuhrer

Publikováno v: Frontiers in Oncology
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology, 10. FRONTIERS MEDIA SA
Zhang, T, van Die, I, Tefsen, B, van Vliet, S J, Laan, L C, Zhang, J, ten Dijke, P, Wuhrer, M & Belo, A I 2020, ' Differential O-and Glycosphingolipid Glycosylation in Human Pancreatic Adenocarcinoma Cells With Opposite Morphology and Metastatic Behavior ', Frontiers in Oncology, vol. 10, 732 . https://doi.org/10.3389/fonc.2020.00732
Frontiers in Oncology, 10:732. Frontiers Media S.A.

Changes in the glycosylation profile of cancer cells have been strongly associated with cancer progression. To increase our insights into the role of glycosylation in human pancreatic ductal adenocarcinoma (PDAC), we performed a study on O-glycans an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0438a866ce73effe020252523095f3d4
http://europepmc.org/articles/PMC7280451

Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells

Autor: Gerd Bouma, Lisa C. Laan, Elsenoor J. Klaver, Richard D. Cummings, I. van Die, T C T M van der Pouw Kraan, Helene Kringel, Georg Kraal

Publikováno v: Genes and Immunity, 16(6), 378-387
Klaver, E J, van der Pouw-Kraan, T C T M, Laan, L C, Kringel, H, Cummings, R D, Bouma, G, Kraal, G & van Die, I 2015, ' Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells ', Genes and Immunity, vol. 16, no. 6, pp. 378-387 . https://doi.org/10.1038/gene.2015.18

Inflammatory immune disorders such as inflammatory bowel disease and multiple sclerosis are major health problems. Currently, the intestinal whipworm Trichuris suis is being explored in clinical trials to reduce inflammation in these diseases; howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbf45366cf3b8a2af440f4ae6c1a5d9
https://doi.org/10.1038/gene.2015.18

The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells

Autor: Helene Kringel, Hakan Kalay, Martin Giera, Gijs Kooij, Richard D. Cummings, Manfred Wuhrer, Peter Nejsum, Iliyan Vlasakov, Lisa C. Laan, Christine D. Dijkstra, Andrew R. Williams, Stig Milan Thamsborg, Kathrin Stavenhagen, Irma van Die

Publikováno v: FASEB Journal, 31(2), 719-731
FASEB Journal, 31(2), 719-731. FASEB
Laan, L C, Williams, A R, Stavenhagen, K, Giera, M, Kooij, G, Vlasakov, I, Kalay, H, Kringel, H, Nejsum, P, Thamsborg, S M, Wuhrer, M, Dijkstra, C D, Cummings, R D & Van Die, I 2017, ' The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells ', FASEB Journal, vol. 31, no. 2, pp. 719-731 . https://doi.org/10.1096/fj.201600841R

Clinical trials have shown that administration of the nematode Trichuris suis can be beneficial in treating various immune disorders. To provide insight into themechanisms by which this wormsuppresses inflammatory responses, an active component was p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e1c5ad15a2fbe7e81b770d6ac723a3
https://hdl.handle.net/1887/114815