Supplementary Information from A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Autor: Richard Wooster, P. Andrew Futreal, Michael R. Stratton, David N. Louis, Tracy T. Batchelor, Wolf Mueller, Kymberly K. Levine, Jennifer E. Roy, Gregory Riggins, Douglas F. Easton, Andy Yates, Sara Widaa, Sofie West, Jennifer Varian, Calli Tofts, Helen Solomon, Alexandra Small, Rebecca Shepherd, David Richardson, Keiran Raine, Robert Petty, Janet Perry, Andrew Menzies, Richard Lugg, Ross Laman, Vivienne Kosmidou, David Jones, Andy Jenkinson, Jonathon Hinton, Katy Hills, Rachel Harrison, Kelly Halliday, Kristian Gray, Matthew Gorton, Simon Forbes, Ed Dicks, Jennifer Cole, Jody Clements, Adam Butler, Gemma Buck, Lisa Brackenbury, Syd Barthorpe, Tim Avis, Adrian Parker, Sarah O'Meara, Helen Davies, Graham Bignell, Sarah Edkins, Chris Greenman, Jon Teague, Claire Stevens, Philip Stephens, Daniel P. Cahill, Raffaella Smith, Chris Hunter

Supplementary Information from A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d0e7301459a6795af7b4fc360e50d5
https://doi.org/10.1158/0008-5472.22366754.v1

Supplementary Glioma Gene Mutations from A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Autor: Richard Wooster, P. Andrew Futreal, Michael R. Stratton, David N. Louis, Tracy T. Batchelor, Wolf Mueller, Kymberly K. Levine, Jennifer E. Roy, Gregory Riggins, Douglas F. Easton, Andy Yates, Sara Widaa, Sofie West, Jennifer Varian, Calli Tofts, Helen Solomon, Alexandra Small, Rebecca Shepherd, David Richardson, Keiran Raine, Robert Petty, Janet Perry, Andrew Menzies, Richard Lugg, Ross Laman, Vivienne Kosmidou, David Jones, Andy Jenkinson, Jonathon Hinton, Katy Hills, Rachel Harrison, Kelly Halliday, Kristian Gray, Matthew Gorton, Simon Forbes, Ed Dicks, Jennifer Cole, Jody Clements, Adam Butler, Gemma Buck, Lisa Brackenbury, Syd Barthorpe, Tim Avis, Adrian Parker, Sarah O'Meara, Helen Davies, Graham Bignell, Sarah Edkins, Chris Greenman, Jon Teague, Claire Stevens, Philip Stephens, Daniel P. Cahill, Raffaella Smith, Chris Hunter

Supplementary Glioma Gene Mutations from A Hypermutation Phenotype and Somatic MSH6 Mutations in Recurrent Human Malignant Gliomas after Alkylator Chemotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ae2ab66f6628c677ca985204a900e72
https://doi.org/10.1158/0008-5472.22366760.v1

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Autor: Jacqueline K. White, Anna-Karin Gerdin, Natasha A. Karp, Ed Ryder, Marija Buljan, James N. Bussell, Jennifer Salisbury, Simon Clare, Neil J. Ingham, Christine Podrini, Richard Houghton, Jeanne Estabel, Joanna R. Bottomley, David G. Melvin, David Sunter, Niels C. Adams, David Tannahill, Darren W. Logan, Daniel G. MacArthur, Jonathan Flint, Vinit B. Mahajan, Stephen H. Tsang, Ian Smyth, Fiona M. Watt, William C. Skarnes, Gordon Dougan, David J. Adams, Ramiro Ramirez-Solis, Allan Bradley, Karen P. Steel, Lauren Baker, Caroline Barnes, Ryan Beveridge, Emma Cambridge, Damian Carragher, Prabhjoat Chana, Kay Clarke, Yvette Hooks, Natalia Igosheva, Ozama Ismail, Hannah Jackson, Leanne Kane, Rosalind Lacey, David Tino Lafont, Mark Lucas, Simon Maguire, Katherine McGill, Rebecca E. McIntyre, Sophie Messager, Lynda Mottram, Lee Mulderrig, Selina Pearson, Hayley J. Protheroe, Laura-Anne Roberson, Grace Salsbury, Mark Sanderson, Daniel Sanger, Carl Shannon, Paul C. Thompson, Elizabeth Tuck, Valerie E. Vancollie, Lisa Brackenbury, Wendy Bushell, Ross Cook, Priya Dalvi, Diane Gleeson, Bishoy Habib, Matt Hardy, Kifayathullah Liakath-Ali, Evelina Miklejewska, Stacey Price, Debarati Sethi, Elizabeth Trenchard, Dominique von Schiller, Sapna Vyas, Anthony P. West, John Woodward, Elizabeth Wynn, Arthur Evans, David Gannon, Mark Griffiths, Simon Holroyd, Vivek Iyer, Christian Kipp, Morag Lewis, Wei Li, Darren Oakley, David Richardson, Damian Smedley, Chukwuma Agu, Jackie Bryant, Liz Delaney, Nadia I. Gueorguieva, Helen Tharagonnet, Anne J. Townsend, Daniel Biggs, Ellen Brown, Adam Collinson, Charles-Etienne Dumeau, Evelyn Grau, Sarah Harrison, James Harrison, Catherine E. Ingle, Helen Kundi, Alla Madich, Danielle Mayhew, Tom Metcalf, Stuart Newman, Johanna Pass, Laila Pearson, Helen Reynolds, Caroline Sinclair, Hannah Wardle-Jones, Michael Woods, Liam Alexander, Terry Brown, Francesca Flack, Carole Frost, Nicola Griggs, Silvia Hrnciarova, Andrea Kirton, Jordan McDermott, Claire Rogerson, Gemma White, Pawel Zielezinski, Tia DiTommaso, Andrew Edwards, Emma Heath, Mary Ann Mahajan, Binnaz Yalcin

Publikováno v: Cell
Cell; Vol 154
Cell, 2013, 154, pp.452-464. ⟨10.1016/j.cell.2013.06.022⟩

Summary Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context. We describe a program, the Sanger Institute Mouse Genetics Project, that provides a step toward the aim of knocking out all genes and screen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4537fde4bfb5a641d2d4531b15325c7
http://europepmc.org/articles/PMC3717207

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set

Autor: Andy Jenkinson, Janet Perry, Jennifer Varian, Michael R. Stratton, Tony Webb, Claire Stevens, Tim Avis, Alex Small, Lisa Brackenbury, Kristian Gray, David S. Richardson, Kelly Halliday, Thomas Santarius, Ogechi Ikediobi, Graham R. Bignell, Syd Barthorpe, Keiran Raine, Calli Tofts, Andrew Menzies, Jennifer Cole, Sarah Edkins, Rachel Harrison, Sarah O’Meara, Raffaella Smith, Jody Clements, Helen Davies, Rebecca Shepherd, Helen Solomon, Tatiana Mironenko, Adrian Parker, David T. Jones, John N. Weinstein, Christopher I. Hunter, Katy Hills, William C. Reinhold, P. Andrew Futreal, Vivienne Kosmidou, Jonathan Hinton, Adam Butler, Jon W. Teague, Andrew D. Yates, Philip J. Stephens, Gemma Buck, Richard Lugg, Ed Dicks, Simon A. Forbes, Richard Wooster, Sara Widaa, Sofie West

Publikováno v: Molecular cancer therapeutics. 5(11)

The panel of 60 human cancer cell lines (the NCI-60) assembled by the National Cancer Institute for anticancer drug discovery is a widely used resource. The NCI-60 has been characterized pharmacologically and at the molecular level more extensively t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a23ce5956c82521e5c3c6ccd4840927
https://pubmed.ncbi.nlm.nih.gov/17088437

Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults

Autor: J. Wolter Oosterhuis, Tim Avis, Gemma Buck, Ruud J.H.L.M. van Gurp, Michael R. Stratton, Simon A. Forbes, Richard Wooster, Kelly Halliday, Adam Butler, Raffaella Smith, Philip J. Stephens, Lisa Brackenbury, Jody Clements, Jon W. Teague, Jennifer Cole, Sarah Edkins, Anthony Webb, Katy Hills, Helen Davies, Yvonne Stephens, Keiran Raine, Ed Dicks, Sara Widaa, Claire Stevens, Adrian Parker, Sarah O’Meara, Christopher Greenman, Ross Laman, Christopher I. Hunter, Syd Barthorpe, P. Andrew Futreal, Leendert H. J. Looijenga, Ken Edwards, Rachel Harrison, Rebecca Shepherd, Helen Solomon, Andrew D. Yates, David T. Jones, Kristian Gray, Sofie West, Matthew Gorton, Robert Petty, Andrew Menzies, Ad J. M. Gillis, Vivienne Kosmidou, Janet Perry, Alexandra Small, Jennifer Varian, Jonathon Hinton, Calli Tofts, Graham R. Bignell, Hans Stoop, Richard Lugg

Publikováno v: Genes Chromosomes & Cancer, 45, 42-46. Wiley-Liss Inc.
Genes Chromosomes Cancer

The protein kinase gene family is the most frequently mutated in human cancer. Previous work has documented activating mutations in the KIT receptor tyrosine kinase in testicular germ-cell tumors (TGCT). To investigate further the potential role of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3630a8946fdb34594ed2e0ffa8b95c
https://pure.eur.nl/en/publications/4a08d5f7-ce0c-4fcd-afc7-8c186385ab34