Výsledky vyhledávání

Simultaneous penetration monitoring of oil component and active drug from fluorinated nanoemulsions

Autor: Hanspeter Kählig, Eva Maria Kulovits, Lisa Binder, Johannes Jatschka, Simone Seeböck, Claudia Valenta

Publikováno v: International Journal of Pharmaceutics. 552:312-318

In the field of dermal drug delivery, determining the penetration depth of actives is a standard procedure for the development of novel formulations. Regarding the vehicle components, respective penetration studies are rather scarce due to their ofte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4285660e12421718d82e86ee25acbe89
https://doi.org/10.1016/j.ijpharm.2018.10.012

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Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study

Autor: Victoria Klang, Dominique Jasmin Lunter, Ziwei Zhang, Claudia Valenta, Michael Wolzt, Safoura Sheikh Rezaei, Olivia Neuer, Lisa Binder

Publikováno v: International journal of pharmaceutics. 571

Important aspects in the development of new dermal drug delivery systems are the formulations' physicochemical properties and stability. Moreover, their influence on skin physiology and their penetration performance in vivo are of crucial interest. W

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4a4a62fe640a7ae98b878ed375489c
https://pubmed.ncbi.nlm.nih.gov/31525444

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The role of viscosity on skin penetration from cellulose ether‐based hydrogels

Autor: Claudia Valenta, Victoria Klang, Lisa Binder, Julia Mazál, Romana Petz

Publikováno v: Skin Research and Technology

Background The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20efd94530c096396a50e3516688e5af
https://doi.org/10.1111/srt.12709

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Penetration monitoring of drugs and additives by ATR-FTIR spectroscopy/tape stripping and confocal Raman spectroscopy - A comparative study

Autor: Lisa Binder, Dieter Baurecht, Romana Petz, Johanna Ruthofer, Claudia Valenta, Victoria Klang, Eva Maria Kulovits

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 130

Vibrational spectroscopy is a useful tool for analysis of skin properties and to confirm the penetration of drugs and other formulation compounds into the skin. In particular, attenuated total reflection Fourier transform infrared (ATR-FTIR) spectros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b128d3fe2758707efafdf8383df853
https://pubmed.ncbi.nlm.nih.gov/29981829

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Investigation of microemulsion microstructure and its impact on skin delivery of flufenamic acid

Autor: Denise-Silvia Mahrhauser, Herwig Peterlik, Kristina Kwizda, Hanspeter Kählig, Claudia Valenta, E. Partyka-Jankowska, Lisa Binder

Publikováno v: International Journal of Pharmaceutics. 490:292-297

Microemulsions are well known penetration enhancing delivery systems. Several properties are described that influence the transdermal delivery of active components. Therefore, this study aimed to characterize fluorosurfactant-based microemulsions and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd544499aee51af5e9104e360a57b4b
https://doi.org/10.1016/j.ijpharm.2015.05.056

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Novel concentrated water-in-oil emulsions based on a non-ionic silicone surfactant: Appealing application properties and tuneable viscoelasticity

Autor: Johannes Jatschka, Michael Wirth, Dieter Baurecht, Lisa Binder, Claudia Valenta

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 120

Silicone excipients are non-irritating ingredients that are extensively used in topical formulations. In the present study, innovative water-in-oil emulsions with a high water content stabilised by a non-ionic silicone surfactant were developed. Effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d57f2ee4a7c75a800c1af2e3b9527d4
https://pubmed.ncbi.nlm.nih.gov/28807818

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Simultaneous analysis of skin penetration of surfactant and active drug from fluorosurfactant-based microemulsions

Autor: Hanspeter Kählig, Magdalena Hoppel, Denise Mahrhauser, Judith Schöll, Lisa Binder, Claudia Valenta

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 88(1)

The purpose of this study was to investigate the penetrated amount of the incorporated model drug diclofenac-sodium and of a fluorosurfactant as specific vehicle constituent of topically applied microemulsions at the same time. To this end, the penet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb1afa7293d0407a90dbad4fed5c5f0
https://pubmed.ncbi.nlm.nih.gov/24892508

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