Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lisa Belfiore"'
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103234- (2024)
Summary: To improve human hepatotoxicity prediction, in vitro liver cell models replicating hepatocyte function, drug metabolism, and toxicity are required. Here, we present a protocol for creating 3D primary human hepatocyte (PHH) cell models using
Externí odkaz:
https://doaj.org/article/f4b054c43be74ff989bf3d1b7c2999b8
Publikováno v:
SLAS Technology, Vol 27, Iss 1, Pp 32-38 (2022)
Advanced three dimensional cell culture techniques have been adopted in many laboratories to better model in vivo tissue by recapitulating multi-cellular architecture and the presence of extracellular matrix features. We describe here a 3D cell cultu
Externí odkaz:
https://doaj.org/article/83a72ad505b1415885982cdc9a14a500
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 641 (2020)
The urokinase plasminogen activator and its receptor (uPA/uPAR) are biomarkers for metastasis, especially in triple-negative breast cancer. We prepared anti-mitotic N-alkylisatin (N-AI)-loaded liposomes functionalized with the uPA/uPAR targeting liga
Externí odkaz:
https://doaj.org/article/e0e22e6ec93d4b77a111d520206598d6
Autor:
Kara L. Vine, Lisa Belfiore, Luke Jones, Julie M. Locke, Samantha Wade, Elahe Minaei, Marie Ranson
Publikováno v:
Heliyon, Vol 2, Iss 1 (2016)
The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that show potential in overcoming MDR are the N-alkylated isatins. In particular 5,7-dibromo-N-
Externí odkaz:
https://doaj.org/article/85e6a5bd64de42fa9610062895bfa467
Publikováno v:
SLAS Technology. 27:32-38
Advanced three dimensional cell culture techniques have been adopted in many laboratories to better model in vivo tissue by recapitulating multi-cellular architecture and the presence of extracellular matrix features. We describe here a 3D cell cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0e0bbf78db976e52b5fe4f10e7909d1
https://doi.org/10.1016/j.slast.2021.10.002
https://doi.org/10.1016/j.slast.2021.10.002
Autor:
Nicholas J. Geraghty, Sam R. Adhikary, Debbie Watson, Lisa Belfiore, Stephen I. Alexander, Ronald Sluyter
Publikováno v:
Transplant Immunology. 54:38-46
Graft-versus-host disease (GVHD) is a frequent complication following allogeneic hematopoietic stem cell transplantation (HSCT) with current therapies limited to general immunosuppression. Humanized mouse models of GVHD are emerging as valuable inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfea78eede2cc87d817e65db9f73426b
https://doi.org/10.1016/j.trim.2019.02.003
https://doi.org/10.1016/j.trim.2019.02.003
Autor:
Cameron J. Ferris, Behnaz Aghaei, Lyndon J. Raftery, Lisa Belfiore, Andrew M. K. Law, Christine Yee, Martin Engel, Alexander Volkerling, Jeremy C. Dobrowolski, Alberto Piloni, Angie D. Tjandra
Successful preclinical drug testing relies in part on data generated using in vitro cell culture models that recapitulate the structure and function of tumours and other tissues in vivo. The growing evidence that 3D cell models can more accurately pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5291cdb599438da0e058528042d1ca61
https://hdl.handle.net/10453/154146
https://hdl.handle.net/10453/154146
Advanced three-dimensional cell culture techniques have been adopted in many laboratories to better modelin vivotissue by recapitulating multi-cellular architecture and the presence of extracellular matrix features. We describe here a 3D cell culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b6dede282c96646c386b51e08944086
https://doi.org/10.1101/2021.04.21.440768
https://doi.org/10.1101/2021.04.21.440768
Publikováno v:
Journal of Controlled Release, 278, 80-86. Elsevier Bedrijfsinformatie b.v.
Despite the longstanding existence of liposome technology in drug delivery applications, there have been no ligand-directed liposome formulations approved for clinical use to date. This lack of translation is due to several factors, one of which is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::275203694d0cd587dcd3b5ca6e4432df
https://doi.org/10.1016/j.jconrel.2018.03.022
https://doi.org/10.1016/j.jconrel.2018.03.022
Autor:
Debbie Watson, Diane Ly, Stephen I. Alexander, Nicholas J. Geraghty, Stephen J. Fuller, W Varikatt, Vanessa Sluyter, Martina L. Sanderson-Smith, Sam R. Adhikary, Ronald Sluyter, Lisa Belfiore
Publikováno v:
Clinical and Experimental Immunology. 190:79-95
SummaryGraft-versus-host disease (GVHD) remains a major problem after allogeneic haematopoietic stem cell transplantation, a curative therapy for haematological malignancies. Previous studies have demonstrated a role for the adenosine triphosphate (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb0d239b7458210937d345aed6bc312
https://doi.org/10.1111/cei.13005
https://doi.org/10.1111/cei.13005