Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lisa Beatrice Caruso"'
Autor:
Sarah Preston-Alp, Lisa Beatrice Caruso, Chenhe Su, Kelsey Keith, Samantha S. Soldan, Davide Maestri, Jozef Madzo, Andrew Kossenkov, Giorgia Napoletani, Benjamin Gewurz, Paul M. Lieberman, Italo Tempera
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Epstein-Barr virus (EBV) is associated with 10% of human gastric carcinomas, which are distinguished by a CpG island methylator phenotype. In gastric carcinoma tumors and cell lines, the EBV genome also exhibits a high degree of 5-methyl cyt
Externí odkaz:
https://doaj.org/article/6a1e68a25f2743b5ba8846d77af44340
Autor:
Sarah M. Morgan, Hideki Tanizawa, Lisa Beatrice Caruso, Michael Hulse, Andrew Kossenkov, Jozef Madzo, Kelsey Keith, Yinfei Tan, Sarah Boyle, Paul M. Lieberman, Italo Tempera
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Genome folding in the nucleus plays an important role in regulating gene expression. Here the authors show that 3D genome architecture also plays an important role for gene expression adaptability for the Epstein-Barr Virus (EBV), a virus that is ass
Externí odkaz:
https://doaj.org/article/424a49de5634470e8123f77694842c45
Publikováno v:
Viruses, Vol 15, Iss 5, p 1088 (2023)
Epstein–Barr Virus (EBV) is a human gamma-herpesvirus that is widespread worldwide. To this day, about 200,000 cancer cases per year are attributed to EBV infection. EBV is capable of infecting both B cells and epithelial cells. Upon entry, viral D
Externí odkaz:
https://doaj.org/article/4b4dcd3308374a9fb6d2c1cba4d9c594
Autor:
Lisa Beatrice Caruso, Rui Guo, Kelsey Keith, Jozef Madzo, Davide Maestri, Sarah Boyle, Jason Wasserman, Andrew Kossenkov, Benjamin E. Gewurz, Italo Tempera
Publikováno v:
PLoS Pathogens, Vol 18, Iss 4 (2022)
The Epstein Barr virus (EBV) infects almost 95% of the population worldwide. While typically asymptomatic, EBV latent infection is associated with several malignancies of epithelial and lymphoid origin in immunocompromised individuals. In latently in
Externí odkaz:
https://doaj.org/article/5dc97abd85824706a7f8e1e15248ec51
Autor:
Bac Viet Le, Paulina Podszywalow-Bartnicka, Silvia Maifrede, Katherine Sullivan-Reed, Margaret Nieborowska-Skorska, Konstantin Golovine, Juo-Chin Yao, Reza Nejati, Kathy Q. Cai, Lisa Beatrice Caruso, Julian Swatler, Michal Dabrowski, Zhaorui Lian, Peter Valent, Elisabeth M. Paietta, Ross L. Levine, Hugo F. Fernandez, Martin S. Tallman, Mark R. Litzow, Jian Huang, Grant A. Challen, Daniel Link, Italo Tempera, Mariusz A. Wasik, Katarzyna Piwocka, Tomasz Skorski
Publikováno v:
Cell Reports, Vol 33, Iss 1, Pp 108221- (2020)
Summary: Synthetic lethality triggered by PARP inhibitor (PARPi) yields promising therapeutic results. Unfortunately, tumor cells acquire PARPi resistance, which is usually associated with the restoration of homologous recombination, loss of PARP1 ex
Externí odkaz:
https://doaj.org/article/60f114cafa24497a8542aae9dc95851f
Autor:
Tomasz Skorski, Grant A. Challen, Neil Johnson, Katarzyna Piwocka, Italo Tempera, George S. Vassiliou, Giovanni Martinelli, Jian Huang, Mark D. Minden, Mark R. Litzow, Hugo F. Fernandez, Martin S. Tallman, Elisabeth M. Paietta, Peter Valent, Stephen M. Sykes, Georg Greiner, Giorgia Simonetti, Daniela Di Marcantonio, Ksenia Matlawska-Wasowska, Boris A. Bartholdy, Kumaraswamy N. Chitrala, Antonella Padella, Zhaorui Lian, Zachary Gazze, Lisa Beatrice Caruso, Jozef Madzo, Kelsey Keith, Michael Hulse, Joseph Nacson, Wangisa M.B. Dunuwille, Katherine Sullivan-Reed, Konstantin Golovine, Margaret Nieborowska-Skorska, Bac Viet Le, Silvia Maifrede
Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies that affect the epigenetic regulation of DNA methylation. Mutations in both genes often co-occur with activating mutations in genes encoding oncogenic tyrosine k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbb1df0a7c02d673032e64a0cd119330
https://doi.org/10.1158/0008-5472.c.6513157.v1
https://doi.org/10.1158/0008-5472.c.6513157.v1
Autor:
Tomasz Skorski, Grant A. Challen, Neil Johnson, Katarzyna Piwocka, Italo Tempera, George S. Vassiliou, Giovanni Martinelli, Jian Huang, Mark D. Minden, Mark R. Litzow, Hugo F. Fernandez, Martin S. Tallman, Elisabeth M. Paietta, Peter Valent, Stephen M. Sykes, Georg Greiner, Giorgia Simonetti, Daniela Di Marcantonio, Ksenia Matlawska-Wasowska, Boris A. Bartholdy, Kumaraswamy N. Chitrala, Antonella Padella, Zhaorui Lian, Zachary Gazze, Lisa Beatrice Caruso, Jozef Madzo, Kelsey Keith, Michael Hulse, Joseph Nacson, Wangisa M.B. Dunuwille, Katherine Sullivan-Reed, Konstantin Golovine, Margaret Nieborowska-Skorska, Bac Viet Le, Silvia Maifrede
Supplementary Methods and Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef655f58c103814cc748c3a244a0498
https://doi.org/10.1158/0008-5472.22428823
https://doi.org/10.1158/0008-5472.22428823
Autor:
Margaret Nieborowska-Skorska, Kumaraswamy Naidu Chitrala, Joseph Nacson, Daniela Di Marcantonio, Georg Greiner, Mark R. Litzow, Neil Johnson, George S. Vassiliou, Martin S. Tallman, Grant A. Challen, Kelsey Keith, Antonella Padella, Giovanni Martinelli, Lisa Beatrice Caruso, Elisabeth Paietta, Tomasz Skorski, Konstantin Golovine, Jian Huang, Jozef Madzo, Giorgia Simonetti, Silvia Maifrede, Ksenia Matlawska-Wasowska, Bac Viet Le, Katherine Sullivan-Reed, Katarzyna Piwocka, Peter Valent, Mark D. Minden, Michael Hulse, Hugo F. Fernandez, Stephen M. Sykes, Zachary Gazze, Italo Tempera, Wangisa M.B. Dunuwille, Boris Bartholdy, Zhaorui Lian
Publikováno v:
Cancer Res
Somatic variants in TET2 and DNMT3A are founding mutations in hematological malignancies that affect the epigenetic regulation of DNA methylation. Mutations in both genes often co-occur with activating mutations in genes encoding oncogenic tyrosine k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfcad7568b45bdfe1e0f5035fd9cda9c
https://europepmc.org/articles/PMC8487956/
https://europepmc.org/articles/PMC8487956/
Autor:
Tomasz Skorski, Katarzyna Piwocka, Peter Valent, Juo-Chin Yao, Margaret Nieborowska-Skorska, Martin S. Tallman, Mark R. Litzow, Jian Huang, Paulina Podszywalow-Bartnicka, Zhaorui Lian, Konstantin Golovine, Julian Swatler, Elisabeth Paietta, Silvia Maifrede, Italo Tempera, Michal Dabrowski, Lisa Beatrice Caruso, Kathy Q. Cai, Daniel C. Link, Bac Viet Le, Grant A. Challen, Ross L. Levine, Reza Nejati, Hugo F. Fernandez, Katherine Sullivan-Reed, Mariusz A. Wasik
Publikováno v:
Cell Rep
Cell Reports, Vol 33, Iss 1, Pp 108221-(2020)
Cell Reports, Vol 33, Iss 1, Pp 108221-(2020)
Summary: Synthetic lethality triggered by PARP inhibitor (PARPi) yields promising therapeutic results. Unfortunately, tumor cells acquire PARPi resistance, which is usually associated with the restoration of homologous recombination, loss of PARP1 ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b730b81428cdf33b7a646c0fc7f395
https://pubmed.ncbi.nlm.nih.gov/33027668
https://pubmed.ncbi.nlm.nih.gov/33027668
Autor:
Micheal Siciliano, Lena N Lupey-Green, Aaron Abraham, Lisa Beatrice Caruso, Italo Tempera, Tomasz Skorski, Elisabetta Lauretti, Kayla A. Martin, Michael Hulse
Publikováno v:
Oncotarget
The enzyme Poly(ADP-ribose) polymerase 1 (PARP1) plays a very important role in the DNA damage response, but its role in numerous aspects is not fully understood. We recently showed that in the absence of DNA damage, PARP1 regulates the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cf619c66e34681074e69471d9de919
https://doi.org/10.18632/oncotarget.24291
https://doi.org/10.18632/oncotarget.24291