Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lisa Barros de Andrade e Sousa"'
Autor:
Yanying Yu, Sandra Gawlitt, Lisa Barros de Andrade e Sousa, Erinc Merdivan, Marie Piraud, Chase L. Beisel, Lars Barquist
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-22 (2024)
Abstract CRISPR interference (CRISPRi) is the leading technique to silence gene expression in bacteria; however, design rules remain poorly defined. We develop a best-in-class prediction algorithm for guide silencing efficiency by systematically inve
Externí odkaz:
https://doaj.org/article/b3fe9104d58c45dab45798f7f6947605
Autor:
David Rügamer, Chris Kolb, Cornelius Fritz, Florian Pfisterer, Philipp Kopper, Bernd Bischl, Ruolin Shen, Christina Bukas, Lisa Barros de Andrade e Sousa, Dominik Thalmeier, Philipp F. M. Baumann, Lucas Kook, Nadja Klein, Christian L. Müller
Publikováno v:
Journal of Statistical Software, Vol 105, Pp 1-31 (2023)
In this paper we describe the implementation of semi-structured deep distributional regression, a flexible framework to learn conditional distributions based on the combination of additive regression models and deep networks. Our implementation encom
Externí odkaz:
https://doaj.org/article/da18f6b48a9a4792973885c91aad0334
Autor:
Louis B. Kuemmerle, Malte D. Luecken, Alexandra B. Firsova, Lisa Barros de Andrade e Sousa, Lena Straßer, Lukas Heumos, Ilhem Isra Mekki, Krishnaa T. Mahbubani, Alexandros Sountoulidis, Tamás Balassa, Ferenc Kovacs, Peter Horvath, Marie Piraud, Ali Ertürk, Christos Samakovlis, Fabian J. Theis
Targeted spatial transcriptomics methods capture the topology of cell types and states in tissues at single cell- and subcellular resolution by measuring the expression of a predefined set of genes. The selection of an optimal set of probed genes is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1680be11e0f1dc924c379a2c7c630916
https://doi.org/10.1101/2022.08.16.504115
https://doi.org/10.1101/2022.08.16.504115
Autor:
Yanying Yu, Sandra Gawlitt, Lisa Barros de Andrade e Sousa, Erinc Merdivan, Marie Piraud, Chase L. Beisel, Lars Barquist
CRISPR interference (CRISPRi), the targeting of a catalytically dead Cas protein to block transcription, is the leading technique to silence gene expression in bacteria. However, design rules for CRISPRi remain poorly defined, limiting predictable de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b400b4d5115e389a6b215a5aa2712b47
https://doi.org/10.1101/2022.05.27.493707
https://doi.org/10.1101/2022.05.27.493707
Publikováno v:
BioRxiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::b400b4d5115e389a6b215a5aa2712b47
Autor:
Yunhee Jeong, Lisa Barros de Andrade e Sousa, Dominik Thalmeier, Reka Toth, Marlene Ganslmeier, Kersten Breuer, Christoph Plass, Pavlo Lutsik
Publikováno v:
Brief. Bioinform. 23:bbac248 (2022)
DNA methylation analysis by sequencing is becoming increasingly popular, yielding methylomes at single-base pair and single-molecule resolution. It has tremendous potential for cell-type heterogeneity analysis using intrinsic read-level information.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c5ff4e24aa076f5fed7051f6c95edcc
https://doi.org/10.1101/2021.11.29.470374
https://doi.org/10.1101/2021.11.29.470374
Autor:
Annalisa Marsico, Edda G. Schulz, John T. Lis, Chong-Jian Chen, Iris Jonkers, Edith Heard, Benjamin Foret, Ilona Dunkel, Christel Picard, Lisa Barros de Andrade e Sousa, Julie Chaumeil, Laurène Syx
Publikováno v:
Genome Research
Genome Research, 29(7), 1087-1099. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
Genome Research, 29(7), 1087-1099. COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
To initiate X-Chromosome inactivation (XCI), the long noncoding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in female mammals to equalize gene dosage between the sexes. The efficiency of gene silencing is highly variable acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f703cc0f518f88e1fb4c0aaa8d7753a8
https://hdl.handle.net/11370/4d450bf1-6be9-4be2-ba4b-a9e5154da622
https://hdl.handle.net/11370/4d450bf1-6be9-4be2-ba4b-a9e5154da622
Autor:
Laurène Syx, Benjamin Foret, Iris Jonkers, John T. Lis, Lisa Barros de Andrade e Sousa, Edith Heard, Edda G. Schulz, Annalisa Marsico, Christel Picard, Julie Chaumeil, Chong-Jian Chen
To initiate X-chromosome inactivation (XCI), the long non-coding RNA Xist mediates chromosome-wide gene silencing of one X chromosome in female mammals to equalize gene dosage between the sexes. The efficiency of gene silencing, however is highly var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec60d50b4736bb07ee6ecf8d02a70b8c
https://doi.org/10.1101/510198
https://doi.org/10.1101/510198
Autor:
Lisa, Barros de Andrade E Sousa, Iris, Jonkers, Laurène, Syx, Ilona, Dunkel, Julie, Chaumeil, Christel, Picard, Benjamin, Foret, Chong-Jian, Chen, John T, Lis, Edith, Heard, Edda G, Schulz, Annalisa, Marsico
Publikováno v:
Genome research. 29(7)
To initiate X-Chromosome inactivation (XCI), the long noncoding RNA Xist mediates chromosome-wide gene silencing of one X Chromosome in female mammals to equalize gene dosage between the sexes. The efficiency of gene silencing is highly variable acro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f254bd5badc59762758a6542ef1222f
https://pubmed.ncbi.nlm.nih.gov/31175153
https://pubmed.ncbi.nlm.nih.gov/31175153
Publikováno v:
PeerJ
microRNAs are small, non-coding RNAs involved in post-transcriptional gene regulation. Since the dysregulation of only a few miRNAs can affect many biological pathways, miRNAs are thought to play a key role in cancer development and can be used as bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3edf5127db9ec4ee34e69ca739c9c9a