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pro vyhledávání: '"Lisa Amanda Holm Rottbøll"'
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 78:58-65
Introduction The objectives of this study were to characterize antimicrobial drug penetration into the pulmonary epithelial lining fluid (PELF) and extracellular fluid (ECF) of muscle in relation to physicochemical properties of the drugs (molecular
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 114:226-232
Target site drug determinations are crucial for optimizing treatment of infectious diseases. There is limited knowledge of antibiotic drug penetration into the pulmonary epithelial lining fluid (PELF) and a lack of easily performed methods for contin
Autor:
Lisa Amanda Holm Rottbøll, Henrik Jeldtoft Jensen, Kristiane Barington, Kerstin Skovgaard, Christian Friis
Publikováno v:
Basicclinical pharmacologytoxicology. 117(4)
Recent intrabronchial microdialysis data indicate that the respiratory epithelium is highly permeable to drugs. Of concern is whether intrabronchial microdialysis disrupts the integrity of the respiratory epithelium and thereby alters drug penetratio