Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Lisa Acquaviva"'
Development of Novel Dual Binders as Potent, Selective, and Orally Bioavailable Tankyrase Inhibitors
Autor:
Zihao Hua, Bryan Egge, Erin L. Mullady, Hakan Gunaydin, John L. Buchanan, Steve Schneider, Xin Huang, Yohannes Teffera, Renee Emkey, Howard Bregman, Randy Serafino, Mary K. Stanton, Erin F. DiMauro, Jingzhou Liu, Virginia Berry, Douglas Saffran, Angel Guzman-Perez, Jennifer Dovey, Liyue Huang, Craig A. Strathdee, Susan M. Turci, Yan Gu, Paul S. Andrews, John Newcomb, Cindy Wilson, Ankita Mishra, Lisa Acquaviva, Nagasree Chakka
Publikováno v:
Journal of Medicinal Chemistry. 56:10003-10015
Tankyrases (TNKS1 and TNKS2) are proteins in the poly ADP-ribose polymerase (PARP) family. They have been shown to directly bind to axin proteins, which negatively regulate the Wnt pathway by promoting β-catenin degradation. Inhibition of tankyrases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba595497eee0272affa9da310eb1804
https://doi.org/10.1021/jm401317z
https://doi.org/10.1021/jm401317z
Autor:
Xin Huang, Susan M. Turci, Zihao Hua, Randy Serafino, Liyue Huang, Jin Tang, Jason Brooks Human, Ryan White, Lisa Acquaviva, Jennifer Dovey, Barbara Grubinska, Oleg Epstein, Doug Saffran, Huilin Zhao, Steve Schneider, Howard Bregman, Hongbing Huang, Anne B. O’Connor, Violeta Yu, John Newcomb, Jonathan T. Goldstein, Nagasree Chakka, Matthew W. Martin, Vinod F. Patel, Craig A. Strathdee, Virginia Berry, Alexander M. Long, Cindy Wilson, Erin F. DiMauro, Hakan Gunaydin
Publikováno v:
ACS Medicinal Chemistry Letters. 3:1059-1064
Aberrant activation of the Wnt pathway is believed to drive the development and growth of some cancers. The central role of CK1γ in Wnt signal transduction makes it an attractive target for the treatment of Wnt-pathway dependent cancers. We describe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc43848aa690914df587add69f5cd2c3
https://doi.org/10.1021/ml300278f
https://doi.org/10.1021/ml300278f
Autor:
Virginia Berry, Steve Schneider, Liyue Huang, Doug Saffran, Cindy Wilson, Randy Serafino, Angel Guzman-Perez, Lisa Acquaviva, Hongbing Huang, Erin F. DiMauro, Hakan Gunaydin, Howard Bregman, Jennifer Dovey, Xin Huang
Publikováno v:
ACS medicinal chemistry letters. 4(12)
Aberrant activation of the Wnt pathway has been implicated in the development and formation of many cancers. TNKS inhibition has been shown to antagonize Wnt signaling via Axin stabilization in APC mutant colon cancer cell lines. We employed structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ef8e3bcb6d05e86c367e97e24980add
https://pubmed.ncbi.nlm.nih.gov/24900633
https://pubmed.ncbi.nlm.nih.gov/24900633