Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lisa A. Westfield"'
Autor:
Lisa A. Westfield, Ara Metjian, Joshua Muia, Ayad Hamdan, Patricia Nieters, J. Evan Sadler, Anita Rodrigues, Ana G. Antun, Jeffrey I. Zwicker, Leili Dolatshahi
Publikováno v:
Blood
TO THE EDITOR: The introduction of plasmapheresis with plasma exchange has increased survival in patients with thrombotic thrombocytopenic purpura (TTP) from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35ec477cd0cb0f24279908456b9b288
https://doi.org/10.1182/blood.2019000795
https://doi.org/10.1182/blood.2019000795
Autor:
Karen Vanhoorelbeke, Garima Gupta, Lisa A. Westfield, Jian Zhu, Joshua Muia, Niraj H. Tolia, J. Evan Sadler
Human ADAMTS13 is a multidomain protein with metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys-rich (C), and spacer (S) domains, followed by 7 additional T domains and 2 CUB (complement components C1r and C1s, sea urchin protein Ue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::007b7b6959f15a5ee803c2fafc51b68d
https://lirias.kuleuven.be/handle/123456789/648516
https://lirias.kuleuven.be/handle/123456789/648516
Autor:
Jian Zhu, Lisa A. Westfield, Garima Gupta, Joshua Muia, Suellen Greco, Karen Vanhoorelbeke, J. Evan Sadler
The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats member 13) prevents microvascular thrombosis by cleaving von Willebrand factor (VWF) within platelet-rich thrombi, and cleavage depends on allosteric a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a7816ae8cf9321bd0bfc252022440d
https://lirias.kuleuven.be/handle/123456789/648517
https://lirias.kuleuven.be/handle/123456789/648517
Autor:
Joshua Muia, Sandra L. Haberichter, Lisa A. Westfield, Kenneth D. Friedman, Garima Gupta, John E. Heuser, Hendrik B. Feys, Jian Zhu, Niraj H. Tolia, Karen Vanhoorelbeke, J. Evan Sadler, Louis Deforche, Robyn Roth
Publikováno v:
Proceedings of the National Academy of Sciences. 111:18584-18589
The metalloprotease ADAMTS13 cleaves von Willebrand factor (VWF) within endovascular platelet aggregates, and ADAMTS13 deficiency causes fatal microvascular thrombosis. The proximal metalloprotease (M), disintegrin-like (D), thrombospondin-1 (T), Cys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe4813ee32c78ec9c759616b4e45641
https://doi.org/10.1073/pnas.1413282112
https://doi.org/10.1073/pnas.1413282112
Autor:
Jian Zhu, Weiqiang Gao, Elodee A. Tuley, Lisa A. Westfield, J. Evan Sadler, Patricia J. Anderson
Publikováno v:
Journal of Biological Chemistry. 287:26944-26952
ADAMTS proteases typically employ some combination of ancillary C-terminal disintegrin-like, thrombospondin-1, cysteine-rich, and spacer domains to bind substrates and facilitate proteolysis by an N-terminal metalloprotease domain. We constructed chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a66d7e46a4fc49008b1ffb04e5ea568
https://doi.org/10.1074/jbc.m112.380535
https://doi.org/10.1074/jbc.m112.380535
Publikováno v:
Journal of Biological Chemistry. 286:25763-25769
von Willebrand factor (VWF) is a multimeric plasma protein that mediates platelet adhesion to sites of vascular injury. The hemostatic function of VWF depends upon the formation of disulfide-linked multimers, which requires the VWF propeptide (D1D2 d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d4e0663635f4b1b6a89b058e112005
https://doi.org/10.1074/jbc.m111.249151
https://doi.org/10.1074/jbc.m111.249151
Autor:
Joshua Muia, Anita Rodrigues, Ana G. Antun, Ara Metjian, Patricia Nieters, J. Evan Sadler, Lisa A. Westfield, Jeffrey I. Zwicker, Leili Dolatshahi
Publikováno v:
Blood. 132:374-374
Introduction:Acquired thrombotic thrombocytopenic purpura (TTP) is caused by autoantibodies against ADAMTS13 that prevent the cleavage of von Willebrand factor and allow the growth of microvascular thrombi, causing microangiopathic hemolysis and seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::340a4b819ebfacacb677910b300ccf40
https://doi.org/10.1182/blood-2018-99-113677
https://doi.org/10.1182/blood-2018-99-113677
Publikováno v:
Biophysical Journal. 98(8):1685-1693
Von Willebrand factor (VWF) is a multimeric plasma glycoprotein involved in both hemostasis and thrombosis. VWF conformational changes, especially unfolding of the A2 domain, may be required for efficient enzymatic cleavage in vivo. It has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2bea63ff895a68f26a45d85e44007d
Publikováno v:
Blood. 104:415-419
Mutations in human prothrombin that generate a stable form of meizothrombin or meizothrombin(desF1) cause dysprothrombinemia in both the homozygous and heterozygous state, suggesting that meizothrombin has dominant anticoagulant effects in vivo. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be9e467c9be188bbeab4844a4bb75a4
https://doi.org/10.1182/blood-2004-02-0478
https://doi.org/10.1182/blood-2004-02-0478
Autor:
Joshua Muia, Jian Zhu, S. C. Covill, L. Dolatshahi, Sandra L. Haberichter, Weiqiang Gao, Kenneth D. Friedman, J E Sadler, Lisa A. Westfield
Publikováno v:
Journal of thrombosis and haemostasis : JTH. 11(8)
Most ADAMTS13 assays use non-physiological conditions (low ionic strength, low pH, barium chloride), are subject to interference from plasma proteins, hemoglobin and bilirubin, and have limited sensitivity, especially for inhibitors.We addressed thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50745b3a39081e8a9039af1dfefeb055
https://pubmed.ncbi.nlm.nih.gov/23773695
https://pubmed.ncbi.nlm.nih.gov/23773695