Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lisa A. Pitcher"'
Autor:
Steven Haenchen, Thornton W. Thompson, Heba H. Mostafa, Adam M. Bayless, David J. Davido, Anna S. Kushnir, Joshua G. Hilliard, Emma Loveday, Malen A. Link, Priscilla A. Schaffer, Lisa A. Pitcher
Publikováno v:
Journal of Virology. 85:12631-12637
In cell culture experiments, phosphorylation appears to be a critical regulator of the herpes simplex virus 1 (HSV-1) immediate-early (IE) protein, ICP0, which is an E3 ubiquitin ligase that transactivates viral gene expression. Three major regions o
Autor:
Søren E. Degn, Santiago F. Gonzalez, Michael C. Carroll, Lisa A. Pitcher, Matthew C. Woodruff, Balthasar A. Heesters
Publikováno v:
Aarhus University
The clonal selection theory first proposed by Macfarlane Burnet is a cornerstone of immunology ( 1 ). At the time, it revolutionized the thinking of immunologists because it provided a simple explanation for lymphocyte specificity, immunological memo
Autor:
Siamon Gordon, Mary J. Cloninger, Santiago F. Gonzalez, Luisa Martinez-Pomares, Michael Kuligowski, Michael C. Carroll, Shannon J. Turley, Lisa A. Pitcher, Søren E. Degn, Young-A. Kim, Veronika Lukacs-Kornek
Publikováno v:
Aarhus University
Gonzalez, S F, Lukacs-Kornek, V, Kuligowski, M P, Pitcher, L A, Degn, S E, Kim, Y-A, Cloninger, M J, Martinez-Pomares, L, Gordon, S, Turley, S J & Carroll, M C 2010, ' Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes ', Nature Immunology, vol. 11, no. 5, pp. 427-435 .
Gonzalez, S F, Lukacs-Kornek, V, Kuligowski, M P, Pitcher, L A, Degn, S E, Kim, Y-A, Cloninger, M J, Martinez-Pomares, L, Gordon, S, Turley, S J & Carroll, M C 2010, ' Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes ', Nature Immunology, vol. 11, no. 5, pp. 427-435 .
A major pathway for B cell acquisition of lymph-borne particulate antigens relies on antigen capture by subcapsular sinus macrophages of the lymph node. Here we tested whether this mechanism is also important for humoral immunity to inactivated influ
Publikováno v:
Journal of Biological Chemistry. 282:16126-16134
The activation of protein kinases is one of the primary mechanisms whereby T cell receptors (TCR) propagate intracellular signals. To date, the majority of kinases known to be involved in the early stages of TCR signaling are protein-tyrosine kinases
Publikováno v:
Proceedings of the National Academy of Sciences. 102:2904-2909
During T cell activation, T cell receptors (TCR) cluster at the center of the T cell/antigen-presenting cell interface forming a key component of the immunological synapse. The function of this TCR clustering is still unresolved. A comprehensive sear
Autor:
Meredith A. Mathis, Ruedi Aebersold, Amanda Campbell, Philip C. Wrage, Rob Hooft van Huijsduijnen, Nicolai S. C. van Oers, Jennifer A. Young, Beatrix Bartók, Sébastien Wälchli, Julian D. Watts, Lisa A. Pitcher, Margaret S. Sozio
Publikováno v:
Journal of Biological Chemistry. 279:7760-7769
Protein-tyrosine phosphatases (PTPases) play key roles in regulating tyrosine phosphorylation levels in cells, yet the identity of their substrates remains limited. We report here on the identification of PTPases capable of dephosphorylating the phos
Publikováno v:
The Journal of Immunology. 171:845-852
The functional effects of altered peptide ligands on T cells is proposed to involve differential intracellular signaling mediated by the 21- and 23-kDa tyrosine-phosphorylated derivatives of the TCR ζ subunit (p21 and p23). To understand the functio
Autor:
Philip C. Wrage, Jennifer A. Young, Meredith A. Mathis, Nicolai S. C. van Oers, Lisa A. Pitcher, Beatrix Bartók
Publikováno v:
Immunological Reviews. 191:47-61
The interaction between the T cell receptor (TCR) and its cognate antigen/major histocompatibility complex (MHC) complex activates a cascade of intracellular protein phosphorylations within the T cell. The signals are initiated by the specific phosph
Autor:
Sophie E. Acton, Raymond A. Sobel, Shannon J. Turley, Vijay K. Kuchroo, Estelle Bettelli, Michael C. Carroll, Anneli Peters, Kai W. Wucherpfennig, Bettina Franz, Lisa A. Pitcher, Meike Mitsdoerffer, Jenna M. Sullivan
SummaryEctopic lymphoid follicles are hallmarks of chronic autoimmune inflammatory diseases such as multiple sclerosis (MS), rheumatoid arthritis, Sjögren's syndrome, and myasthenia gravis. However, the effector cells and mechanisms that induce thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513fb4d2116a5ba6a78982af5e1b2c42
https://europepmc.org/articles/PMC3422678/
https://europepmc.org/articles/PMC3422678/
Autor:
Santiago F, Gonzalez, Michael P, Kuligowski, Lisa A, Pitcher, Ramon, Roozendaal, Michael C, Carroll
Publikováno v:
Advances in immunology. 106
Over the past decade, it has become apparent that B cells acquire antigens primarily from membrane surfaces and that uptake is an active process involving a synapse between the B cell receptor, coreceptor, and the antigen surface. However, understand