Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lisa A. Paige"'
Publikováno v:
The Journal of Neuroscience. 24:7999-8008
Transcriptional dysregulation by mutant huntingtin (Htt) protein has been implicated in the pathogenesis of Huntington's disease (HD). We find that cultured cells expressing mutant Htt and striatal cells from HD transgenic mice have elevated nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346d65aab5f90546b4af446f27b1631d
https://doi.org/10.1523/jneurosci.2675-04.2004
https://doi.org/10.1523/jneurosci.2675-04.2004
Publikováno v:
Receptors and Channels. 9:125-131
The Cytosensor microphysiometer uses silicon chip technology to correlate changes in extracellular acidification rates with quantitative changes in cellular metabolism in response to ligand binding to surface receptors. This functional measure of phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc80a80f8140218794b77932b8de296
https://doi.org/10.1080/10606820308246
https://doi.org/10.1080/10606820308246
Autor:
Dale J. Christensen, Karen Padilla, Lawrence Michael Ballas, Lisa A. Paige, Dana M. Fowlkes, Ching-Yi Chang, Elizabeth B. Gottlin, Donald P. McDonnell, Hanne Grøn, John D. Norris, Paul Hamilton
Publikováno v:
Proceedings of the National Academy of Sciences. 96:3999-4004
Estrogen receptor (ER) modulators produce distinct tissue-specific biological effects, but within the confines of the established models of ER action it is difficult to understand why. Previous studies have suggested that there might be a relationshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b346c34172ca763bd4659cab4c566674
https://doi.org/10.1073/pnas.96.7.3999
https://doi.org/10.1073/pnas.96.7.3999
Publikováno v:
Journal of Biological Chemistry. 268:8669-8674
The myristoylated protein-tyrosine kinase, p56lck, is expressed predominantly in T cells where it is believed to play a role in T cell activation. We observed a 56-kDa protein that became metabolically labeled in intact T lymphoid cells that were inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6e64c3d8733603b7a527751f3873118
https://doi.org/10.1016/s0021-9258(18)52927-6
https://doi.org/10.1016/s0021-9258(18)52927-6
Autor:
Rima Kaddurah-Daouk, K. Ranga Rama Krishnan, Lisa A. Paige, David C. Steffens, Matthew W. Mitchell
Publikováno v:
International journal of geriatric psychiatry. 22(5)
Background Metabolomics, the global science of biochemistry, is an emerging field that enables detection and quantification of small molecules involved in metabolic and signaling pathways. Metabolic signatures for disease and its treatment could prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bc226ce740564b20d55cde4fb1b643
https://pubmed.ncbi.nlm.nih.gov/17048218
https://pubmed.ncbi.nlm.nih.gov/17048218
Publikováno v:
Analytical Biochemistry. 202:68-70
A method for the preparation of a biotinylated resin that can be elongated by standard methods of solid-phase peptide synthesis to give peptides biotinylated at the carboxy terminus is described. This methodology is particularly important for the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46cb1a978595c8849908bcfe18d70309
https://doi.org/10.1016/0003-2697(92)90207-n
https://doi.org/10.1016/0003-2697(92)90207-n
Autor:
PA Wendler, J Kranz, ZL Fredericks, Lisa A. Paige, Dale J. Christensen, J Zhang, Paul Hamilton, N Hyde-DeRuyscher, Audrey Lim, Dana M. Fowlkes, SM Rocklage, Robin Hyde-Deruyscher, Paul Gallant
Publikováno v:
Chemistrybiology. 7(1)
Background: The rapidly expanding list of pharmacologically important targets has highlighted the need for ways to discover new inhibitors that are independent of functional assays. We have utilized peptides to detect inhibitors of protein function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfff6e65a2c7a676a12ca567a2206d8
https://pubmed.ncbi.nlm.nih.gov/10662687
https://pubmed.ncbi.nlm.nih.gov/10662687
Autor:
Hanne Grøn, Donald P. McDonnell, Ching-Yi Chang, Paul Hamilton, Lisa A. Paige, John D. Norris, Dana M. Fowlkes, Daniel J. Kenan
Recruitment of transcriptional coactivators following ligand activation is a critical step in nuclear receptor-mediated target gene expression. Upon binding an agonist, the receptor undergoes a conformational change which facilitates the formation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb226f8c613499308eb868b5e60c9a1e
https://europepmc.org/articles/PMC84907/
https://europepmc.org/articles/PMC84907/
Autor:
Lisa A. Paige, Daju Fan, Paul Hamilton, Ching-Yi Chang, Donald P. McDonnell, John D. Norris, Dale J. Christensen, Dana M. Fowlkes, Maria R. Huacani
Publikováno v:
Science (New York, N.Y.). 285(5428)
Estrogen receptor alpha transcriptional activity is regulated by distinct conformational states that are the result of ligand binding. Phage display was used to identify peptides that interact specifically with either estradiol- or tamoxifen-activate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54cdc5bb432ac44c985f6646abf040c
https://pubmed.ncbi.nlm.nih.gov/10426998
https://pubmed.ncbi.nlm.nih.gov/10426998
Autor:
Marjorie S. Solomon, Stacia M. Rink, B. Mitra Tadayoni-Rebek, Lisa A. Paige, Robert G. Croy, Kevin J. Yarema, John M. Essigmann
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 93(26)
It is a goal of cancer chemotherapy to achieve the selective killing of tumor cells while minimizing toxicity to normal tissues. We describe the design of selective toxins forming DNA adducts that attract the estrogen receptor (ER), a transcription f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5561a56ddeec4973f2aa914b5739b4ff
https://pubmed.ncbi.nlm.nih.gov/8986764
https://pubmed.ncbi.nlm.nih.gov/8986764