Výsledky vyhledávání - "Lisa A. Lund"

Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:2076-2080

The discovery of heteroaryl-phenyl-substituted pyrazole derivatives as canine selective COX-2 inhibitors is described. Structure–activity relationship (SAR) studies of this class of compounds led to the identification of compound 1 which demonstrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096af07029de50fcfe74128b57b3a069
https://doi.org/10.1016/j.bmcl.2006.01.059

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5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure–activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:288-292

Structure-activity relationship (SAR) studies of the novel 2-[3-di and trifluoromethyl-5-alkylamino pyrazo-1-yl]-5-methanesulfonyl (SO(2)Me)/sulfamoyl (SO(2)NH(2))-pyridine derivatives for canine COX enzymes are described. The studies led to the iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f287d246c2a3746f106e9752c3bac59e
https://doi.org/10.1016/j.bmcl.2005.10.006

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In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, a potent, selective, and orally active canine COX-2 inhibitor

Autor: Burton H. Jaynes, Michelle L. Haven, Scott B. Seibel, Nicole L. Kolosko, Carolyn Rose Kilroy, Kristin M. Lundy DeMello, Donald W. Mann, Michael P. Lynch, Cheng Hengmiao, Lisa A. Lund, Robert J. Rafka, Jin Li, Carol F. Petras, Subas M. Sakya, Bronk Brian Scott

Publikováno v: Bioorganic & Medicinal Chemistry. 13:1805-1809

The synthesis of a novel canine COX-2 selective inhibitor, 2-(3-difluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyridine, and its in vitro and in vivo profile are described. Pyrazole 8 demonstrated excellent potency and selectivity for canine C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::442d5fd80e9563aadcaab6043c177abd
https://doi.org/10.1016/j.bmc.2004.11.048

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Discovery of a potent, selective and orally active canine COX-2 inhibitor, 2-(3-difluoromethyl-5-phenyl-pyrazol-1-yl)-5-methanesulfonyl-pyridine

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:95-98

Structure-activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes are described. This led to the identification of 12a as a lead candidate for further progre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03f71036c4dab955ec24afc57075467a
https://doi.org/10.1016/j.bmcl.2003.10.004

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Glutathione and bile acid synthesis. Effect of GSH content of HepG2 cells on the activity and mRNA levels of cholesterol 7α-hydroxylase

Autor: Lisa A. Lund, David Bunick, Walter Bottje, Aslam S. Hassan

Publikováno v: Biochemical Pharmacology. 44:1475-1477

Cholesterol 7 alpha-hydroxylase (CH-7 alpha) activity in HepG2 cells depleted of glutathione (GSH) was reduced significantly (P < 0.05) compared to that in untreated controls. Northern blot analysis of poly A+ mRNA isolated from GSH-depleted and cont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e8f120ca4a673492ab03d624ece4a62
https://doi.org/10.1016/0006-2952(92)90553-u

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Characterization and phylogenetic significance of rhinoceros luteinizing hormone beta (LHbeta) subunit messenger RNA structure, complementary DNA sequence and gene copy number

Autor: Lisa A. Lund, Robert J Winn, Gary B Sherman, David Bunick

Publikováno v: Gene. 195(2)

The luteinizing hormone (LH) beta subunit gene is expressed in the pituitary glands of all mammals, whereas the closely related chorionic gonadotropin (CG) beta subunit genes have been identified only in primates and equids, and are expressed in plac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab532dba08c872eff8a03dd2234149ff
https://pubmed.ncbi.nlm.nih.gov/9305757

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Glutathione and bile acid synthesis. II. Effect of hepatic glutathione content on the activity and mRNA levels of cholesterol 7α-hydroxylase in the rat

Autor: Suzanne H. St. Denis, David Bunick, Aslam S. Hassan, Lisa A. Lund

Publikováno v: Biochemical Pharmacology. 46:555-556

Hepatic cholesterol 7 alpha-hydroxylase (CH-7 alpha) activity in intact rats depleted of glutathione (GSH) was reduced significantly (P < 0.007) compared with that in untreated controls. Northern blot analysis of poly A+ mRNA isolated from GSH-deplet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18370cb3686f23d8eac4391d29036000
https://doi.org/10.1016/0006-2952(93)90536-6

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