Výsledky vyhledávání - "Lisa A. Kosmiski"

Influence of CYP2C8*2 on the Pharmacokinetics of Pioglitazone in Healthy African-American Volunteers

Autor: Lisa A. Kosmiski, Julie A. Predhomme, Samantha H. Spencer, Michael F. Wempe, Christina L. Aquilante, Maha S. Sidhom

Publikováno v: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 33:1000-1007

Study Objectives To determine the influence of the Cytochrome P450 (CYP) 2C8*2 polymorphism on pioglitazone pharmacokinetics in healthy African-American volunteers. Design Prospective, open-label, single-dose pharmacokinetic study. Setting University

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01ab19ed41146169e3b39bf5c02c9d2
https://doi.org/10.1002/phar.1292

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Impact of theCYP2C8*3polymorphism on the drug-drug interaction between gemfibrozil and pioglitazone

Autor: Merry Le, Maha S. Sidhom, David W. A. Bourne, Charles W. Hopley, Kyle P. Hammond, Julie A. Predhomme, Uday B. Kompella, Alexander T. Kanack, Elizabeth B. Daily, Lane R. Bushman, Joseph E. Rower, Rajendra S. Kadam, Christina L. Aquilante, Lisa A. Kosmiski

Publikováno v: British Journal of Clinical Pharmacology. 75:217-226

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • A drug–drug interaction exists between gemfibrozil (CYP2C8 inhibitor) and pioglitazone (CYP2C8 substrate), whereby gemfibrozil increases pioglitazone plasma exposure. Substantial interindividual variabil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05391c5a755486f62dc4f6947c20f3fd
https://doi.org/10.1111/j.1365-2125.2012.04343.x

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Pharmacodynamic Effects of Low-Dose Pioglitazone in Patients with the Metabolic Syndrome without Diabetes Mellitus

Autor: Ronald L. Prigeon, Julie A. Predhomme, Anh Vu, Christina L. Aquilante, Kimberly M. Deininger, Maha S. Sidhom, Lisa A. Kosmiski, Brooke C Bredbeck, Amber L. Beitelshees

Publikováno v: Pharmacotherapy. 36(3)

Study Objective To determine the effects of low-dose pioglitazone on plasma adipocyte-derived cytokines, high-sensitivity C-reactive protein (hs-CRP), and components of the metabolic syndrome in adults with the metabolic syndrome without diabetes mel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c71e185d47378b2aa6681cfb58a31b0a
https://pubmed.ncbi.nlm.nih.gov/26822630

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Energy expenditure in HIV infection

Autor: Lisa A. Kosmiski

Publikováno v: The American Journal of Clinical Nutrition. 94:1677S-1682S

Energy intake recommendations for adults should be based preferably on direct measurements of total daily energy expenditure (TDEE) in corresponding populations who are maintaining healthy body weight and satisfactory physical activity levels. During

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2be7830d640a64014c21641b6296af
https://doi.org/10.3945/ajcn.111.012625

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Association of Increased Upper Trunk and Decreased Leg Fat With 2-h Glucose in Control and HIV-Infected Persons

Autor: Mary L. Biggs, Lisa A. Kosmiski, Rebecca Scherzer, Michael S. Simberkoff, Steven B. Heymsfield, Peter Bacchetti, Michael G. Shlipak, David Rimland, Stephen Sidney, Carl Grunfeld, Metabolic Change in Hiv Infection

Publikováno v: Diabetes Care
Diabetes care, vol 34, iss 11

OBJECTIVE Changes in body fat distribution and abnormal glucose metabolism are common in HIV-infected patients. We hypothesized that HIV-infected participants would have a higher prevalence of impaired glucose tolerance (IGT) compared with control su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c8a2357e25ce0d935a7beb97f63c66
http://europepmc.org/articles/PMC3198295

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Pharmacodynamic Effects of Rosiglitazone in Nondiabetic Patients with Metabolic Syndrome

Autor: Issam Zineh, Shannon D Knutsen, Christina L. Aquilante, Lucille Capo Rome, Lisa A. Kosmiski

Publikováno v: Pharmacotherapy. 30:236-247

Study Objectives. To determine the effects of the thiazolidinedione rosiglitazone on the adipocyte-derived cytokines adiponectin (an antiinflammatory and insulin-sensitizing cytokine; low levels have been associated with metabolic syndrome) and resis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106acf099d7d171f5f520fa7dc868d47
https://doi.org/10.1592/phco.30.3.236

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Relationship of Fat Distribution with Adipokines in Human Immunodeficiency Virus Infection

Autor: Cora E. Lewis, Rebecca Scherzer, Steven B. Heymsfield, Donald P. Kotler, Michael G. Shlipak, Peter Bacchetti, Lisa A. Kosmiski, Carl Grunfeld

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 93:216-224

HIV-infected patients receiving antiretroviral therapy often develop changes in body fat distribution; the dominant change is reduction in sc adipose tissue (SAT). Because adipose tissue makes important hormones involved in whole-body energy metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae4703f5756109effd7f3f64c51b860
https://doi.org/10.1210/jc.2007-1155

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Short-term overfeeding increases resting energy expenditure in patients with HIV lipodystrophy

Autor: Sarah Stotz, Lisa A. Kosmiski, Daniel H. Bessesen, Tracy J. Horton, John Koeppe

Publikováno v: The American Journal of Clinical Nutrition. 86:1009-1015

BACKGROUND HIV lipodystrophy and other lipodystrophy syndromes are characterized by extensive loss of subcutaneous adipose tissue. Lipodystrophy syndromes are also associated with increased resting energy expenditure (REE). This hypermetabolism may b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64cdaa046b3fb96a0c849539f2c660a
https://doi.org/10.1093/ajcn/86.4.1009

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In Combination, Nucleoside Reverse Transcriptase Inhibitors Have Significant Effects on 3T3–L1 Adipocyte Lipid Accumulation and Survival

Autor: Dwight J. Klemm, Lisa A. Kosmiski, Heidi L. Miller

Publikováno v: Antiviral Therapy. 11:187-196

The use of nucleoside reverse transcriptase inhibitors (NRTIs) for the treatment of HIV infection is clearly linked to the development of subcutaneous fat atrophy. Until recently, however, in vitro studies of adipocytes have shown no or only modest a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::411af8993f2ac55c2dbc2c93db20403a
https://doi.org/10.1177/135965350601100202

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