Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Lisa A. Hurley"'
Autor:
Andrea E. Calvert, Alexandra Chalastanis, Yongfei Wu, Lisa A. Hurley, Fotini M. Kouri, Yingtao Bi, Maureen Kachman, Jasmine L. May, Elizabeth Bartom, Youjia Hua, Rama K. Mishra, Gary E. Schiltz, Oleksii Dubrovskyi, Andrew P. Mazar, Marcus E. Peter, Hongwu Zheng, C. David James, Charles F. Burant, Navdeep S. Chandel, Ramana V. Davuluri, Craig Horbinski, Alexander H. Stegh
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1858-1873 (2017)
Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma (GBM). Our in silico and wet-bench analyses indicate that non-mu
Externí odkaz:
https://doaj.org/article/f4d292ac8f8346f8ab26ed8e258f99d4
Autor:
Alexander H. Stegh, Serena Tommasini-Ghelfi, Kevin Murnan, Daniel Wahl, Lisa A. Hurley, Corey Dussold
Publikováno v:
Neuro Oncol
Increased de novo synthesis, mobilization and uptake of fatty acids are required to provide sufficient lipids for membrane biogenesis in support of rapid tumor cell division and growth. In addition to their structural roles as components of the plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a4be238cbc3dacb57b4e841f7ce8c0
https://europepmc.org/articles/PMC8598688/
https://europepmc.org/articles/PMC8598688/
Autor:
Sean Sachdev, Lisa A. Hurley, Roger Stupp, Alexander H. Stegh, Timothy L. Sita, Corey Dussold, Michael Drumm, Craig Horbinski, Kevin Murnan, Akanksha Mahajan, Serena Tommasini-Ghelfi
Publikováno v:
Neuro Oncol
PURPOSE Growing evidence indicates that the neurotransmitters dysregulated in psychiatric disorders are similarly dysregulated in glioblastoma (GBM) biology. GBM cells are dependent on bountiful neuronal glutamate, utilize elevated dopamine receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f7c7f762f62b6a426889e63e63976d
https://europepmc.org/articles/PMC8598562/
https://europepmc.org/articles/PMC8598562/
Autor:
Howard Colman, Si Chen, C. David James, Laura Zuckerman, Olga Antipova, Margaret Schwartz, Daniel J. Brat, Junjing Deng, Dusten Unruh, Mitchell Glass, Caroline H. Ko, Rimas V. Lukas, Orin Bloch, Gayle E. Woloschak, Priya Kumthekar, Barry Lai, Ramana V. Davuluri, Fotini M. Kouri, Craig Horbinski, Borko Jovanovic, Tatjana Paunesku, Vinod Vijayakumar, Ray Lezon, Lisa A. Hurley, Miguel Muzzio, Nitya V. Sharma, Adam M. Sonabend, Francis J. Giles, Jeremy Heidel, Ann K. Adams, Matthew C. Tate, Serena Tommasini-Ghelfi, Luxi Li, Kathleen McCortney, Alexander H. Stegh, Manoj Kandpal, Karan Dixit
Publikováno v:
Science translational medicine, vol 13, iss 584
Sci Transl Med
Sci Transl Med
The lack of precision therapies combined with limited therapeutic access to intracranial tumor sites due to the presence of the blood-brain/blood-tumor barriers have contributed to glioblastoma (GBM) being one of the most difficult cancers to effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b32e3981c0cbcca50f68f14a1475576
https://escholarship.org/uc/item/5601p8jn
https://escholarship.org/uc/item/5601p8jn
Autor:
Corey Dussold, Lisa A. Hurley, Roger Stupp, Timothy L. Sita, Sean Sachdev, Alexander H. Stegh
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 111:e599-e600
Purpose/Objective(s) Growing evidence indicates that the neurotransmitters dysregulated in psychiatric disorders are similarly dysregulated in glioblastoma (GBM) biology. Patients with psychiatric disorders are classically thought of having excessive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6d77f2805dcbc7448ddcd90655b729
https://doi.org/10.1016/j.ijrobp.2021.07.1601
https://doi.org/10.1016/j.ijrobp.2021.07.1601
Autor:
Samuel A. Jensen, Emily S. Day, Caroline H. Ko, Lisa A. Hurley, Janina P. Luciano, Fotini M. Kouri, Timothy J. Merkel, Andrea J. Luthi, Pinal C. Patel, Joshua I. Cutler, Weston L. Daniel, Alexander W. Scott, Matthew W. Rotz, Thomas J. Meade, David A. Giljohann, Chad A. Mirkin, Alexander H. Stegh
Publikováno v:
Spherical Nucleic Acids ISBN: 9780429200151
Spherical Nucleic Acids ISBN: 9781003056713
Spherical Nucleic Acids ISBN: 9781003056713
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e04c16c1bc01cc20d891ddf2b2981db
https://doi.org/10.4324/9780429200151-106
https://doi.org/10.4324/9780429200151-106
Autor:
Motoo Nagane, Honghong Zhang, Lisa A. Hurley, Sali Liu, Chung Kwon Kim, Yilin Xu, Bo Hu, Chonghui Cheng, Shi Yuan Cheng, Ryo Nishikawa, Alexander H. Stegh, Wei Wang
Publikováno v:
Proceedings of the National Academy of Sciences. 114:8366-8371
Significance Abnormal EGFR signaling is frequently observed in glioblastoma multiforme (GBM). However, the clinical benefit of EGFR inhibitors has been limited. Here we show that the cell surface molecule CD44s splice isoform acts as a signaling modu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696b3dd74041bab457e1dc5b0ac39e42
https://doi.org/10.1073/pnas.1701289114
https://doi.org/10.1073/pnas.1701289114
Autor:
Jasmine L. May, Serena Tommasini-Ghelfi, Alexander H. Stegh, Peng Gao, Foteini Kouri, Andrew Lee, Andrea E. Calvert, Navdeep S. Chandel, Yanrong Ji, Craig Horbinski, Juan Liu, Jason W. Locasale, Lisa A. Hurley, Ramana V. Davuluri
Publikováno v:
Science Advances
IDH3α promotes glioblastoma progression and links mitochondrial metabolism to cSHMT-controlled one-carbon metabolism.
Mutation or transcriptional up-regulation of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) promotes cancer progression thr
Mutation or transcriptional up-regulation of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) promotes cancer progression thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ef98aa670ef786fc34c0778b2932599
https://doi.org/10.1126/sciadv.aat0456
https://doi.org/10.1126/sciadv.aat0456
Autor:
David A. Giljohann, Chian Yu Peng, Emily S. Day, Marcus E. Peter, Fotini M. Kouri, Lynda Chin, Carissa Ritner, Lisa A. Hurley, Chad A. Mirkin, Weston L. Daniel, Timothy J. Merkel, John A. Kessler, Youjia Hua, C. David James, Jacob I. Sznajder, Liangliang Hao, Hailei Zhang, Markus A. Queisser, Alexander H. Stegh
Publikováno v:
Genes & Development. 29:732-745
Glioblastoma multiforme (GBM) is a lethal, therapy-resistant brain cancer consisting of numerous tumor cell subpopulations, including stem-like glioma-initiating cells (GICs), which contribute to tumor recurrence following initial response to therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6991206b8b62b9de288cac97d9ca6b2
https://doi.org/10.1101/gad.257394.114
https://doi.org/10.1101/gad.257394.114
Autor:
Fotini M. Kouri, Yingtao Bi, Alexandra Chalastanis, Ramana V. Davuluri, Elizabeth T. Bartom, Gary E. Schiltz, Youjia Hua, Alexander H. Stegh, Lisa A. Hurley, Andrea E. Calvert, Hongwu Zheng, Marcus E. Peter, Yongfei Wu, Craig Horbinski, Andrew P. Mazar, Rama K. Mishra, Jasmine L. May, C. David James, Maureen Kachman, Charles F. Burant, Navdeep S. Chandel, Oleksii Dubrovskyi
Publikováno v:
Cell Reports, Vol 19, Iss 9, Pp 1858-1873 (2017)
Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma, and secondary glioblastoma (GBM). Our in silico and wet-bench analyses indicate that non-mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::192399932f594ecd8019a37699b9bbf5
https://europepmc.org/articles/PMC5564207/
https://europepmc.org/articles/PMC5564207/