Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lisa A. Humphries"'
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133353 (2015)
Functionally diverse CD8+ T cells develop in response to antigenic stimulation with differing capacities to couple TCR engagement to downstream signals and functions. However, mechanisms of diversifying TCR signaling are largely uncharacterized. Here
Externí odkaz:
https://doaj.org/article/eb16aa0b364c41498823d614287b14e3
Autor:
Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45276 (2012)
The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell receptor (TCR) engagement has been implicated in the modulation of T cell development and effector responses. In siRNA-based studies Dlg1,
Externí odkaz:
https://doaj.org/article/5159c08438b74cfcb4ab902da3231388
Autor:
Emma J. Palmer, Lisa M. Humphries
Publikováno v:
Legal and Criminological Psychology. 21:407-416
Purpose This study examined whether there were significant differences between completers and non-completers of an offending behaviour programme on pre-programme measures of impulsivity, social problem-solving, and criminal thinking. Methods Particip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6cd23fc5705ecf56d151f7d1cdb8701
https://doi.org/10.1111/lcrp.12089
https://doi.org/10.1111/lcrp.12089
Autor:
Oscar Silva, Tamar Tomassian, Lisa A. Humphries, David G. Brooks, Scot D. Liu, M. Carrie Miceli
Publikováno v:
The Journal of Immunology. 187:2993-3002
TCR engagement triggers the polarized recruitment of membrane, actin, and transducer assemblies within the T cell–APC contact that amplify and specify signaling cascades and T effector activity. We report that caveolin-1, a scaffold that regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bfa2eae668b90a32cff54bb6803f76
https://doi.org/10.4049/jimmunol.1101447
https://doi.org/10.4049/jimmunol.1101447
Publikováno v:
Nature Reviews Immunology. 7:778-789
Fluctuations in cytosolic calcium concentrations affect numerous signals involved in the development and function of B cells. Recent advances have expanded our understanding of the mechanisms involved in the regulation of cytosolic calcium concentrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbdd83870735e394ffc9c66b71d8e187
https://doi.org/10.1038/nri2172
https://doi.org/10.1038/nri2172
Autor:
Alejandro Zentella, Lucia N. López-Bojórques, Miguel E. Moreno-García, Lisa A. Humphries, Leopoldo Santos-Argumedo, David J. Rawlings
Publikováno v:
The Journal of Immunology. 174:2687-2695
The CD38 cell surface receptor is a potent activator for splenic, B lymphocytes. The molecular mechanisms regulating this response, however, remain incompletely characterized. Activation of the nonreceptor tyrosine kinase, Btk, is essential for CD38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f59305ce5f14a9c523435a165acb1b37
https://doi.org/10.4049/jimmunol.174.5.2687
https://doi.org/10.4049/jimmunol.174.5.2687
Autor:
Karen Sommer, Roberta M. Kato, David J. Rawlings, Christoph W. Turk, James L. Daniel, Natasha Griffith, Carol Dangelmaier, Kevin R. Kipp, Irene Bakman, Lisa A. Humphries
Publikováno v:
Journal of Biological Chemistry. 279:37651-37661
Tyrosine phosphorylation of phospholipase Cgamma2 (PLCgamma2) is a crucial activation switch that initiates and maintains intracellular calcium mobilization in response to B cell antigen receptor (BCR) engagement. Although members from three distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f49ef6878082c7428f6eed8fa52aeed5
https://doi.org/10.1074/jbc.m311985200
https://doi.org/10.1074/jbc.m311985200
Autor:
Lisa A. Humphries, Andrew M. Scharenberg, Jean-Pierre Kinet, Christopher L. Carpenter, Kimberley F. Tolias, David J. Rawlings, Henry B. Koon, Kan Saito, Abdel Saci
Publikováno v:
Immunity. 19:669-677
Intracellular signaling by most cell surface receptors requires the generation of two major second messengers, phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P 3 ) and inositol-1,4,5-trisphosphate (IP 3 ). The enzymes that produce these secon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9225e7846fbf2f5000bfeb2413cb5ccc
https://doi.org/10.1016/s1074-7613(03)00297-8
https://doi.org/10.1016/s1074-7613(03)00297-8
Autor:
C. Peter Downes, Elizabeth Clayton, David Chantry, Martin R Turner, Elena Vigorito, Alexander Gray, Lisa A. Humphries, Giuseppe Bardi, Sarah Bell, Helen Reynolds, David J. Rawlings
Publikováno v:
The Journal of Experimental Medicine
Mice lacking the p110delta catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins, respond poorly to immunization with type II thymus-independent antigen, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49814005b9113b9c685da36982e3cac3
https://doi.org/10.1084/jem.20020805
https://doi.org/10.1084/jem.20020805
Autor:
Keun Chae, Beichu Guo, Yuko Kawakami, David J. Rawlings, Roberta M. Kato, Thomas T. Su, Michael A. Teitell, Toshiaki Kawakami, Randolph Wall, Karen Sommer, Shin Kang, Lisa A. Humphries, Michael Leitges, Lisa Patrone
Publikováno v:
Nature Immunology. 3:780-786
NF-kappa B signaling is required for the maintenance of normal B lymphocytes, whereas dysregulated NF-kappa B activation contributes to B cell lymphomas. The events that regulate NF-kappa B signaling in B lymphocytes are poorly defined. Here, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b72c9e5a05f708a7f872f27013bcf97
https://doi.org/10.1038/ni823
https://doi.org/10.1038/ni823