Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lisa A. Farinelli"'
Autor:
Mehdi Farokhnia, Tammy Wang, Tony Jourdan, Grzegorz Godlewski, Lisa A. Farinelli, George Kunos, Lorenzo Leggio
Publikováno v:
Drug and Alcohol Dependence. 245:109809
Autor:
Sara L. Deschaine, Lisa A. Farinelli, Mary R. Lee, Mehdi Farokhnia, Armin Sadighi, Lorenzo Leggio, Fatemeh Akhlaghi
Publikováno v:
Molecular psychiatry
Previous studies suggest that GABA-B receptor agonism may represent an effective pharmacological approach to treat addictive disorders. Baclofen is a selective GABA-B receptor agonist which has been investigated as a potential treatment for alcohol u
Autor:
Lorenzo Leggio, Mary R. Lee, Mehdi Farokhnia, Fatemeh Akhlaghi, Lisa A. Farinelli, Vijay A. Ramchandani
Publikováno v:
Pharmacology Biochemistry and Behavior. 172:39-49
Ghrelin, an orexigenic peptide synthesized in the stomach, is a key player in the gut-brain axis. In addition to its role in regulating food intake and energy homeostasis, ghrelin has been shown to modulate alcohol-related behaviors. Alcohol consumpt
Autor:
April N. Le, Lorenzo Leggio, Lisa A. Farinelli, Enoch Cobbina, Jenica D. Tapocik, Fatemeh Akhlaghi, Mwlod Ghareeb, Mehdi Farokhnia, Alexandra A. Dias, Markus Heilig, Mary R. Lee, Melanie L. Schwandt, Sofia Bouhlal
Publikováno v:
Molecular psychiatry
Rodent studies indicate that ghrelin receptor blockade reduces alcohol consumption. However, no ghrelin receptor blockers have been administered to heavy alcohol drinking individuals. Therefore, we evaluated the safety, tolerability, pharmacokinetic
Autor:
Mary R. Lee, Melanie L. Schwandt, Erica N. Grodin, Mehdi Farokhnia, A N Blackburn, Bethany L. Stangl, V A Ramchandani, Lorenzo Leggio, Reza Momenan, Emily N. Oot, Lisa A. Farinelli
Publikováno v:
Molecular Psychiatry. 23:2029-2038
Preclinical evidence suggests that ghrelin, a peptide synthesized by endocrine cells of the stomach and a key component of the gut-brain axis, is involved in alcohol seeking as it modulates both central reward and stress pathways. However, whether an
Autor:
Mary R. Lee, Melanie L. Schwandt, Lorenzo Leggio, Lisa A. Farinelli, Mehdi Farokhnia, Fatemeh Akhlaghi
Publikováno v:
The FASEB Journal. 33
Autor:
Fatemeh Akhlaghi, Enoch Cobbina, Xiaobai Li, Anitha Saravanakumar, Jillian T. Battista, Lisa A. Farinelli, Mehdi Farokhnia, Mary R. Lee, Lorenzo Leggio
Publikováno v:
Neuropharmacology
Both animal and human work suggests that the ghrelin system may be involved in the mechanisms that regulate the development and maintenance of alcohol use disorder. Previously, in a Phase 1b study, we tested pharmacological blockade of the growth hor
Autor:
L Sewell, T A Lionetti, Mary R. Lee, Melanie L. Schwandt, D E Spero, Jared W. Bollinger, Mehdi Farokhnia, J P Amodio, Lorenzo Leggio, Lisa A. Farinelli
Publikováno v:
Translational Psychiatry
Baclofen has been suggested as a potential pharmacotherapy for alcohol use disorder, but the clinical data are conflicting. Here we investigated the biobehavioral effects of baclofen in a sample of anxious alcohol-dependent individuals. This was a ra