Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lisa A. Constantine"'
Publikováno v:
Environmental Toxicology and Chemistry. 39:1534-1545
A study was conducted to understand the potential for ibuprofen to impact the hypothalamus-pituitary-gonadal endocrine axis resulting in disruption of fish reproduction. The Good Laboratory Practice study was conducted according to the Organisation f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7f3f99abc7adaf120404a9001d3652
https://doi.org/10.1002/etc.4742
https://doi.org/10.1002/etc.4742
Autor:
Wei Xei, Andreas Häner, Joan Tell, Lisa A. Constantine, Jutta Hellstern, Daniel J. Caldwell, Tim Swenson, Romain Journel, Jessica Vestel, Jim J. Ryan
Publikováno v:
Integrated environmental assessment and management. 18(4)
The pharmaceutical manufacturing industry, via the AMR Industry Alliance, has developed and implemented steps to help minimize the potential impact of pharmaceutical manufacturing on the spread of antimicrobial resistance (AMR). One of these steps wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e45677cd33dd36ee740eb9d115a531
https://pubmed.ncbi.nlm.nih.gov/34826209
https://pubmed.ncbi.nlm.nih.gov/34826209
Autor:
Anupama Kumar, Mary Sue Marty, Laurent Lagadic, Lisa A. Constantine, James P. Meador, Tamar I. Schwarz, Janice E. Chambers, Daniel B. Pickford, Amy Blankinship, Tim Verslycke, Werner Kloas
Publikováno v:
Integrated Environmental Assessment and Management. 13:317-330
For ecotoxicological risk assessment, endocrine disruptors require the establishment of an endocrine mode of action (MoA) with a plausible link to a population-relevant adverse effect. Current ecotoxicity test methods incorporate mostly apical endpoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f2cfff5c3edebe7cd30da67b139800d
https://doi.org/10.1002/ieam.1887
https://doi.org/10.1002/ieam.1887
Autor:
L. Earl Gray, James P. Meador, Gerd Maack, Lennart Weltje, James R. Wheeler, Gerald T. Ankley, Melanie Gross, Peter Matthiessen, Yukio Kawashima, Laurent Lagadic, Mike Williams, Poul Bjerregaard, Patrick D. Guiney, David A. Dreier, Jeffery C. Wolf, Joanne L. Parrott, Lisa A. Constantine, Anu Kumar, Sue Marty, Ioanna Katsiadaki, Tamar I. Schwarz, Janice E. Chambers, Markus Hecker, Zhi-Chao Dang, Nancy D. Denslow, Kristin E. Brugger, Daniel B. Pickford, Henry O. Krueger, Steve Dungey, Annegaaike Leopold, Sarah M. Kadlec, Tim Verslycke, Lisa S. Ortego, Henrik Holbech, Christoph Schaefers, Michael S. Roberts, Steven L. Levine, Taisen Iguchi, Jenny Odum, Katherine K. Coady, Keith R. Solomon, Werner Kloas, Ronald C. Biever, Christopher J. Borgert, Amy Blankinship, Ellen Mihaich, Natalie K. Karouna-Renier, Kunihiko Yamazaki
Publikováno v:
Integrated Environmental Assessment and Management. 13:267-279
A SETAC Pellston Workshop® “Environmental Hazard and Risk Assessment Approaches for Endocrine-Active Substances (EHRA)” was held in February 2016 in Pensacola, Florida, USA. The primary objective of the workshop was to provide advice, based on c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1f283a88e24db9289af3c4fc1d8d7ac
https://doi.org/10.1002/ieam.1885
https://doi.org/10.1002/ieam.1885
Publikováno v:
Environmental Toxicology and Chemistry. 36:636-644
17α-Trenbolone and 17α-estradiol are principal metabolites in cattle excreta following the administration of Synovex® ONE, which contains trenbolone acetate and estradiol benzoate. As part of the environmental assessment of the use of Synovex® ON
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db55774f1e8504439cce5c1d89698ef
https://doi.org/10.1002/etc.3526
https://doi.org/10.1002/etc.3526
Publikováno v:
Bulletin of Environmental Contamination and Toxicology. 96:580-584
Evaluation of the environmental risk of human pharmaceuticals is now a mandatory component in all new drug applications submitted for approval in EU. With >3000 drugs currently in use, it is not feasible to test each active ingredient, so prioritizat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070bda8ec9bee4bf3049e613526b72b7
https://doi.org/10.1007/s00128-016-1782-y
https://doi.org/10.1007/s00128-016-1782-y
Autor:
Jürg Oliver Straub, David G. Dolan, Neil J. Parke, Daniel J. Caldwell, Lisa A. Constantine, Steven P. Millard, Vincent J. D'Aco, Todd Davidson, Jim J. Ryan, Peter R. Wilson, Richard Murray-Smith, Jessica Vestel
Publikováno v:
Environmental Toxicology and Chemistry. 35:1201-1212
For many older pharmaceuticals, chronic aquatic toxicity data are limited. To assess risk during development, scale-up, and manufacturing processes, acute data and physicochemical properties need to be leveraged to reduce potential long-term impacts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aba58ea14333b64762161d9a921ab67
https://doi.org/10.1002/etc.3260
https://doi.org/10.1002/etc.3260
Autor:
Gopinath C. Nallani, Regina Edziyie, Lisa A. Constantine, Barney J. Venables, Peter M. Paulos, Duane B. Huggett
Publikováno v:
Environmental Toxicology and Chemistry. 35:593-603
The present study examined the bioconcentration of 2 basic pharmaceuticals: verapamil (a calcium channel blocker) and clozapine (an antipsychotic compound) in 2 fresh water fishes, fathead minnow and channel catfish. In 4 separate bioconcentration fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe188ac2ed6342adf3e1176ffad542bf
https://doi.org/10.1002/etc.3244
https://doi.org/10.1002/etc.3244
Autor:
David Hala, Carmen L. Overturf, Barney J. Venables, Duane B. Huggett, Lisa A. Constantine, M.D. Overturf, D. Baxter
Publikováno v:
Archives of Environmental Contamination and Toxicology. 62:455-464
Human pharmaceuticals are routinely being detected in the environment, and there is growing concern about whether these drugs could elicit effects on aquatic organisms. Regulatory paradigms have shifted accordingly, with a greater emphasis on chronic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d746d2dc1409c492ca875add19172382
https://doi.org/10.1007/s00244-011-9723-6
https://doi.org/10.1007/s00244-011-9723-6
Publikováno v:
Bulletin of Environmental Contamination and Toxicology. 86:247-251
The presence of pharmaceuticals in the environment has become an important topic of discussion with respect to pharmaceutical absorption, metabolism and elimination in fish. This study investigates the metabolism of ibuprofen by rainbow trout (Oncorh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc2a9ba0a5cb8e48c40b181a3206ff9
https://doi.org/10.1007/s00128-011-0200-8
https://doi.org/10.1007/s00128-011-0200-8