Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lisa A. Borghesi"'
Publikováno v:
The Journal of Immunology. 206:98.45-98.45
Naïve B cells differentiate into short-term and long-lived plasma cells (PCs) following pathogen exposure, contributing to the overall humoral immune response. However, an extensive comparison of murine and human antibody secreting cells (ASCs) that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f4db3567eb46d3f00cf4edd3e838882
https://doi.org/10.4049/jimmunol.206.supp.98.45
https://doi.org/10.4049/jimmunol.206.supp.98.45
Publikováno v:
The Journal of Immunology. 206:55.10-55.10
Naive B cells differentiate into antibody secreting plasma cells (PC) and memory B cells (MBC) that together dictate the quality and persistence of the humoral immune response. However, a comprehensive analysis of human B lineage population structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23537c08553f61a54225d997bb908aa0
https://doi.org/10.4049/jimmunol.206.supp.55.10
https://doi.org/10.4049/jimmunol.206.supp.55.10
Publikováno v:
The Journal of Immunology. 200:166.31-166.31
We have performed a comprehensive analysis of human lymphoid tissue from relatively inaccessible sites including SPL, BM and LN from normal donors. Most of what is known about human B cells comes from blood, a tissue that contains only ~2% of the imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a43cf1020c3f89b78346c4b76f68e8e
https://doi.org/10.4049/jimmunol.200.supp.166.31
https://doi.org/10.4049/jimmunol.200.supp.166.31
Publikováno v:
Seminars in Immunology. 17:347-355
B cell generation and immunoglobulin (Ig) diversity in mice is compromised with aging. Our recent work sought to understand mechanism(s) that contribute to reduced B cell production in aged mice. Using in vivo labeling, we found that reduction in mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609766bf7ceb8719801c469f38c556ae
https://doi.org/10.1016/j.smim.2005.05.012
https://doi.org/10.1016/j.smim.2005.05.012
Autor:
Leonore A. Herzenberg, Mark S. Schlissel, Michael G. Anderson, Rachel M. Gerstein, Lih-Yun Hsu, Lisa A. Borghesi, Juli P. Miller, David Allman, Leonard A. Herzenberg
Publikováno v:
The Journal of Experimental Medicine
Expression of V(D)J recombinase activity in developing lymphocytes is absolutely required for initiation of V(D)J recombination at antigen receptor loci. However, little is known about when during hematopoietic development the V(D)J recombinase is fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228b6fdc61ebd5d278721dc71cb14511
https://doi.org/10.1084/jem.20031800
https://doi.org/10.1084/jem.20031800
Autor:
Lisa A. Borghesi, Rachel M. Gerstein
Publikováno v:
The Journal of Experimental Medicine
In B lineage progenitors, V(D)J recombination occurs only during distinct stages of development and is restricted to immunoglobulin loci. This process is thought to be controlled by both regulated expression of the V(D)J recombinase and by limited ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa9d99f3f49bda9f95e5afa6499cb9f
http://europepmc.org/articles/PMC2211822
http://europepmc.org/articles/PMC2211822
Autor:
Lisa A Borghesi, Ailing Liu, Minhui Chen, Rashmi Kumar, Maja Stefanovic-Racic, Robert O’Doherty, Ying Ding, Willi Jahnen-Dechent
Publikováno v:
The Journal of Immunology. 198:202.16-202.16
Obesity compromises bone marrow (BM) progenitor function and the mechanistic underpinnings are just beginning to be established. Here we show that following 16 weeks of high fat diet, mice exhibit poor emergency hematopoiesis in a toll-like receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c63ea25973479df420887aefee31726
https://doi.org/10.4049/jimmunol.198.supp.202.16
https://doi.org/10.4049/jimmunol.198.supp.202.16
Publikováno v:
Blood. 93:140-148
Heparin/heparan sulfate proteoglycans (HSPGs) have the potential to bind and directly regulate the bioactivity of hematopoietic growth factors including interleukin-7 (IL-7), a cytokine critical for murine B-cell development. We examined the conseque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096069e50d56f440b3996203b658e7f1
https://doi.org/10.1182/blood.v93.1.140.401k40_140_148
https://doi.org/10.1182/blood.v93.1.140.401k40_140_148
Publikováno v:
Vox Sanguinis. 74:265-268
New molecular approaches are rapidly yielding information about the composition of bone marrow and culture studies suggest possible functions for many molecules in that organ. However, the marrow is extraordinarily complex with respect to interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73094abb92637109c4c02a4a18f23c53
https://doi.org/10.1111/j.1423-0410.1998.tb05430.x
https://doi.org/10.1111/j.1423-0410.1998.tb05430.x
Autor:
Lisa A. Borghesi, Michael A. Lynes
Publikováno v:
Toxicology and Applied Pharmacology. 139:6-14
Metallothionein (MT) is a small, cysteine-rich protein that is readily induced by exposure to heavy metal cations. In previous work, we have demonstrated that MT has several significant immunomodulatory properties. MT decreases antigen-specific humor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b164c8b88fb0af4ccaaee54fea1ceb
https://doi.org/10.1006/taap.1996.0137
https://doi.org/10.1006/taap.1996.0137