Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Lisa A Santry"'
Autor:
Jacob P van Vloten, Kathy Matuszewska, Mark A A Minow, Jessica A Minott, Lisa A Santry, Madison Pereira, Ashley A Stegelmeier, Thomas M McAusland, Elaine M Klafuric, Khalil Karimi, Joseph Colasanti, D Grant McFadden, James J Petrik, Byram W Bridle, Sarah K Wootton
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Novel therapies are needed to improve outcomes for women diagnosed with ovarian cancer. Oncolytic viruses are multifunctional immunotherapeutic biologics that preferentially infect cancer cells and stimulate inflammation with the potential
Externí odkaz:
https://doaj.org/article/042f07917dda4af9ab08f790da95d074
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94595 (2014)
BACKGROUND: The phosphatidylinositol 3-kinase-regulated protein kinase, Akt, plays an important role in the initiation and progression of human cancer. Mammalian cells express three Akt isoforms (Akt1-3), which are encoded by distinct genes. Despite
Externí odkaz:
https://doaj.org/article/5ce12eab1b904dbd84b7247eb9ed497f
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51400 (2012)
Lung cancer is the most common cause of cancer-related death worldwide. A poor overall survival rate of 16% necessitates the need for novel treatment strategies. Mouse models of lung cancer are important tools for analyzing the significance of somati
Externí odkaz:
https://doaj.org/article/54784710e84b477398302aa2f7e4d66c
Autor:
Lisa A. Santry, Jacob P. van Vloten, Amanda W. K. AuYeung, Robert C. Mould, Jacob G. E. Yates, Thomas M. McAusland, James J. Petrik, Pierre P. Major, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionTumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory ligands and cytokines, and recruitment of immunomodulatory cells, including myel
Externí odkaz:
https://doaj.org/article/0dc2b238fb124dce87ad725117251258
Autor:
Jessica A. Minott, Jacob P. van Vloten, Jake G.E. Yates, Lisa A. Santry, Kathy Matuszewska, Madison Pereira, Melanie M. Goens, Alicia M. Viloria-Petit, Geoffrey A. Wood, Khalil Karimi, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100748- (2023)
Immunotherapies revive host immune responses against tumors by stimulating innate and adaptive immune effector cells with antitumor functions. Thus, detailed studies of immunological cell phenotypes and functions within the tumor microenvironment (TM
Externí odkaz:
https://doaj.org/article/741bb4cb64894b1a844ac39272790cc9
Autor:
Bryce M. Warner, Mable Chan, Nikesh Tailor, Robert Vendramelli, Jonathan Audet, Courtney Meilleur, Thang Truong, Lauren Garnett, Marnie Willman, Geoff Soule, Kevin Tierney, Alixandra Albietz, Estella Moffat, Rick Higgins, Lisa A. Santry, Alexander Leacy, Phuc H. Pham, Jacob G. E. Yates, Yanlong Pei, David Safronetz, James E. Strong, Leonardo Susta, Carissa Embury-Hyatt, Sarah K. Wootton, Darwyn Kobasa
Publikováno v:
Vaccines, Vol 12, Iss 4, p 404 (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged following an outbreak of unexplained viral illness in China in late 2019. Since then, it has spread globally causing a pandemic that has resulted in millions of deaths and has had e
Externí odkaz:
https://doaj.org/article/5e4cccc3f31e4e15bd81f344156fe762
Autor:
Thomas M. McAusland, Jacob P. van Vloten, Lisa A. Santry, Matthew M. Guilleman, Amira D. Rghei, Edgar M. Ferreira, Joelle C. Ingrao, Rozanne Arulanandam, Pierre P. Major, Leonardo Susta, Khalil Karimi, Jean-Simon Diallo, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 306-324 (2021)
The avian paramyxovirus, Newcastle disease virus (NDV), is a promising oncolytic agent that has been shown to be safe and effective in a variety of pre-clinical cancer models and human clinical trials. NDV preferentially replicates in tumor cells due
Externí odkaz:
https://doaj.org/article/e362ae43ee6b4c3790f29c8383e6c1e4
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Supplementary Data Figure 2 Supplementary Data, Figure 2. ID8, CAOV-3 and NOSE cells were infected or mock infected (1x PBS) at an MOI of 0.1. Infected and uninfected cells were collected 24 hours later and stained for Annexin V a marker for early ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0342e15dc576617cc2d651ebb17dd1bd
https://doi.org/10.1158/1078-0432.22476029.v1
https://doi.org/10.1158/1078-0432.22476029.v1
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Supplementary Figure 1 Supplementary Data, Figure 1. Combination therapy results in decreased ascites fluid volume. At euthanasia, ascites fluid was aspirated from the abdomen of control and treated mice and the volume was quantified. Combined treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167663a398a0d4060d99d31fdcceadca
https://doi.org/10.1158/1078-0432.22476032
https://doi.org/10.1158/1078-0432.22476032
Autor:
Jim Petrik, Byram W. Bridle, Sarah K. Wootton, Jack Lawler, Pierre P. Major, Amanda W.K. AuYeung, Jacob P. van Vloten, Lisa A. Santry, Kathy Matuszewska
Purpose:Intravenous delivery of oncolytic viruses often leads to tumor vascular shutdown, resulting in decreased tumor perfusion and elevated tumor hypoxia. We hypothesized that using 3TSR to normalize tumor vasculature prior to administration of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70162777eeb068f616d113b8fa5e6f1e
https://doi.org/10.1158/1078-0432.c.6529271.v1
https://doi.org/10.1158/1078-0432.c.6529271.v1