Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Lisa A Santry"'
Autor:
Jacob P van Vloten, Kathy Matuszewska, Mark A A Minow, Jessica A Minott, Lisa A Santry, Madison Pereira, Ashley A Stegelmeier, Thomas M McAusland, Elaine M Klafuric, Khalil Karimi, Joseph Colasanti, D Grant McFadden, James J Petrik, Byram W Bridle, Sarah K Wootton
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background Novel therapies are needed to improve outcomes for women diagnosed with ovarian cancer. Oncolytic viruses are multifunctional immunotherapeutic biologics that preferentially infect cancer cells and stimulate inflammation with the potential
Externí odkaz:
https://doaj.org/article/042f07917dda4af9ab08f790da95d074
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94595 (2014)
BACKGROUND: The phosphatidylinositol 3-kinase-regulated protein kinase, Akt, plays an important role in the initiation and progression of human cancer. Mammalian cells express three Akt isoforms (Akt1-3), which are encoded by distinct genes. Despite
Externí odkaz:
https://doaj.org/article/5ce12eab1b904dbd84b7247eb9ed497f
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51400 (2012)
Lung cancer is the most common cause of cancer-related death worldwide. A poor overall survival rate of 16% necessitates the need for novel treatment strategies. Mouse models of lung cancer are important tools for analyzing the significance of somati
Externí odkaz:
https://doaj.org/article/54784710e84b477398302aa2f7e4d66c
Autor:
Lisa A. Santry, Jacob P. van Vloten, Amanda W. K. AuYeung, Robert C. Mould, Jacob G. E. Yates, Thomas M. McAusland, James J. Petrik, Pierre P. Major, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
IntroductionTumor microenvironments are immunosuppressive due to progressive accumulation of mutations in cancer cells that can drive expression of a range of inhibitory ligands and cytokines, and recruitment of immunomodulatory cells, including myel
Externí odkaz:
https://doaj.org/article/0dc2b238fb124dce87ad725117251258
Autor:
Bryce M. Warner, Mable Chan, Nikesh Tailor, Robert Vendramelli, Jonathan Audet, Courtney Meilleur, Thang Truong, Lauren Garnett, Marnie Willman, Geoff Soule, Kevin Tierney, Alixandra Albietz, Estella Moffat, Rick Higgins, Lisa A. Santry, Alexander Leacy, Phuc H. Pham, Jacob G. E. Yates, Yanlong Pei, David Safronetz, James E. Strong, Leonardo Susta, Carissa Embury-Hyatt, Sarah K. Wootton, Darwyn Kobasa
Publikováno v:
Vaccines, Vol 12, Iss 4, p 404 (2024)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged following an outbreak of unexplained viral illness in China in late 2019. Since then, it has spread globally causing a pandemic that has resulted in millions of deaths and has had e
Externí odkaz:
https://doaj.org/article/5e4cccc3f31e4e15bd81f344156fe762
Autor:
Jessica A. Minott, Jacob P. van Vloten, Jake G.E. Yates, Lisa A. Santry, Kathy Matuszewska, Madison Pereira, Melanie M. Goens, Alicia M. Viloria-Petit, Geoffrey A. Wood, Khalil Karimi, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100748- (2023)
Immunotherapies revive host immune responses against tumors by stimulating innate and adaptive immune effector cells with antitumor functions. Thus, detailed studies of immunological cell phenotypes and functions within the tumor microenvironment (TM
Externí odkaz:
https://doaj.org/article/741bb4cb64894b1a844ac39272790cc9
Autor:
Jacob P. van Vloten, Jessica A. Minott, Thomas M. McAusland, Joelle C. Ingrao, Lisa A. Santry, Grant McFadden, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 434-447 (2021)
Poxviruses have been used extensively as vaccine vectors for human and veterinary medicine and have recently entered the clinical realm as immunotherapies for cancer. We present a comprehensive method for producing high-quality lots of the poxvirus P
Externí odkaz:
https://doaj.org/article/80ee3b897ec94e55bc1c335e48d70703
Autor:
Thomas M. McAusland, Jacob P. van Vloten, Lisa A. Santry, Matthew M. Guilleman, Amira D. Rghei, Edgar M. Ferreira, Joelle C. Ingrao, Rozanne Arulanandam, Pierre P. Major, Leonardo Susta, Khalil Karimi, Jean-Simon Diallo, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Oncolytics, Vol 20, Iss , Pp 306-324 (2021)
The avian paramyxovirus, Newcastle disease virus (NDV), is a promising oncolytic agent that has been shown to be safe and effective in a variety of pre-clinical cancer models and human clinical trials. NDV preferentially replicates in tumor cells due
Externí odkaz:
https://doaj.org/article/e362ae43ee6b4c3790f29c8383e6c1e4
Autor:
Bryce M. Warner, Lisa A. Santry, Alexander Leacy, Mable Chan, Phuc H. Pham, Robert Vendramelli, Yanlong Pei, Nikesh Tailor, Emelissa Valcourt, Anders Leung, Shihua He, Bryan D. Griffin, Jonathan Audet, Marnie Willman, Kevin Tierney, Alixandra Albietz, Kathy L. Frost, Jacob G.E. Yates, Robert C. Mould, Lily Chan, Yeganeh Mehrani, Jason P. Knapp, Jessica A. Minott, Logan Banadyga, David Safronetz, Heidi Wood, Stephanie Booth, Pierre P. Major, Byram W. Bridle, Leonardo Susta, Darwyn Kobasa, Sarah K. Wootton
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103219- (2021)
Summary: The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Worldwide efforts are being made to develop vaccines to mitigate this pandemic. We engineered two recombinant Newc
Externí odkaz:
https://doaj.org/article/a9d6cd355eb7470ba0489696155667f5
Autor:
Ashley A. Stegelmeier, Lisa A. Santry, Matthew M. Guilleman, Kathy Matuszewska, Jessica A. Minott, Jacob G. E. Yates, Brenna A. Y. Stevens, Sylvia P. Thomas, Sierra Vanderkamp, Kiersten Hanada, Yanlong Pei, Amira D. Rghei, Jacob P. van Vloten, Madison Pereira, Brad Thompson, Pierre P. Major, James J. Petrik, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 362 (2022)
Epithelial ovarian cancer is the deadliest gynecological malignancy. The lack of effective treatments highlights the need for novel therapeutic interventions. The aim of this study was to investigate whether sustained adeno-associated virus (AAV) vec
Externí odkaz:
https://doaj.org/article/b7a933055d294583b0ee729eeada2323