Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Lisa A Mielke"'
Autor:
David Williams, Gabrielle Belz, Wei Shi, Anita Kumari, Andreas Behren, Maxine Smith, Marina Yakou, Sonia Ghilas, Kelly Tran, Yang Liao, Shoukat Afshar-Sterle, Kevin Schmid, Christine Dijkstra, Chantelle Inguanti, Simone Ostrouska, Jordan Wilcox, Pavitha Parathan, Amr Allam, Hai-Hui Xue, John Mariadason, Grant Drummond, Roland Ruscher, Bhupinder Pal, Matthias Ernst, Dinesh Raghu, Lisa A Mielke
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/53e2c7996d52481f9160ae107e1bb5fa
Autor:
Sharon Tran, Juliani Juliani, Tiffany J. Harris, Marco Evangelista, Julian Ratcliffe, Sarah L. Ellis, David Baloyan, Camilla M. Reehorst, Rebecca Nightingale, Ian Y. Luk, Laura J. Jenkins, Sonia Ghilas, Marina H. Yakou, Chantelle Inguanti, Chad Johnson, Michael Buchert, James C. Lee, Peter De Cruz, Kinga Duszyc, Paul A. Gleeson, Benjamin T. Kile, Lisa A. Mielke, Alpha S. Yap, John M. Mariadason, W. Douglas Fairlie, Erinna F. Lee
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Autophagy-related genes have been closely associated with intestinal homeostasis. BECLIN1 is a component of Class III phosphatidylinositol 3-kinase complexes that orchestrate autophagy initiation and endocytic trafficking. Here we show intes
Externí odkaz:
https://doaj.org/article/fc863b699bb647f5926120d1c9e15000
Autor:
Qiutong Huang, Wang Cao, Lisa Anna Mielke, Cyril Seillet, Gabrielle T. Belz, Nicolas Jacquelot
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
The immune system plays a fundamental role at mucosal barriers in maintaining tissue homeostasis. This is particularly true for the gut where cells are flooded with microbial-derived signals and antigens, which constantly challenge the integrity of t
Externí odkaz:
https://doaj.org/article/81dacf7d9c334c2abc413f6d4535f940
Autor:
Hazel Tye, Chien-Hsiung Yu, Lisa A. Simms, Marcel R. de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S. Penington, Cassandra R. Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F. Wockner, Adele Preaudet, Lisa A. Mielke, Stephen A. Wilcox, Yasunori Ogura, Sinead C. Corr, Komal Kanojia, Konstantinos A. Kouremenos, David P. De Souza, Malcolm J. McConville, Richard A. Flavell, Motti Gerlic, Benjamin T. Kile, Anthony T. Papenfuss, Tracy L. Putoczki, Graham L. Radford-Smith, Seth L. Masters
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby
Externí odkaz:
https://doaj.org/article/289da6d10257442191a1c6fe56d983a8
Autor:
Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F. Pascutti, Anna E. Oja, Alexandra L. Garnham, Renee Gloury, Jessica C. Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W. Kuijpers, Najoua Lalaoui, Lisa A. Mielke, Vanessa L. Bryant, Philip D. Hodgkin, John Silke, Gordon K. Smyth, Martijn A. Nolte, Wei Shi, Axel Kallies
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2906-2920 (2017)
After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully suppressive effector (e)Treg cells in a process dependent on TCR signaling and the transcription
Externí odkaz:
https://doaj.org/article/a6158e2926c7412c92b606577bc61e39
Autor:
Cyril Seillet, Lisa A. Mielke, Daniela B. Amann-Zalcenstein, Shian Su, Jerry Gao, Francisca F. Almeida, Wei Shi, Matthew E. Ritchie, Shalin H. Naik, Nicholas D. Huntington, Sebastian Carotta, Gabrielle T. Belz
Publikováno v:
Cell Reports, Vol 17, Iss 2, Pp 436-447 (2016)
Innate lymphoid cells (ILCs) are enriched at mucosal surfaces, where they provide immune surveillance. All ILC subsets develop from a common progenitor that gives rise to pre-committed progenitors for each of the ILC lineages. Currently, the temporal
Externí odkaz:
https://doaj.org/article/47142904a3f54a61bc57324661408c07
Autor:
Ian Y. Luk, Laura J. Jenkins, Kael L. Schoffer, Irvin Ng, Janson W. T. Tse, Dmitri Mouradov, Stanislaw Kaczmarczyk, Rebecca Nightingale, Allan D. Burrows, Robin L. Anderson, Diego Arango, Higinio Dopeso, Larry Croft, Mark F. Richardson, Oliver M. Sieber, Yang Liao, Jennifer K. Mooi, Natalia Vukelic, Camilla M. Reehorst, Shoukat Afshar-Sterle, Vicki L. J. Whitehall, Lochlan Fennell, Helen E. Abud, Niall C. Tebbutt, Wayne A. Phillips, David S. Williams, Wei Shi, Lisa A. Mielke, Matthias Ernst, Amardeep S. Dhillon, Nicholas J. Clemons, John M. Mariadason
Publikováno v:
Scientia
Epigenetics; Tumour-suppressor proteins Epigenética; Proteínas supresoras de tumores Epigenètica; Proteïnes supresores de tumors Colorectal cancers (CRCs) often display histological features indicative of aberrant differentiation but the molecula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1771def1a2b343893e5c103bb2bd76
Autor:
Sonia, Ghilas, Ryan, O'Keefe, Lisa Anna, Mielke, Dinesh, Raghu, Michael, Buchert, Matthias, Ernst
Publikováno v:
Frontiers in Immunology. 13
The gut epithelium not only provides a physical barrier to separate a noxious outside from a sterile inside but also allows for highly regulated interactions between bacteria and their products, and components of the immune system. Homeostatic mainte
Autor:
Lisa A. Mielke, Sonia Ghilas
Publikováno v:
Trends in Immunology. 42:1063-1065
In two elegant studies, Tyler Jacks' group and colleagues unveil crucial interactions between dendritic cells and TCF1+CD8+ progenitor T cells, shaping their heterogeneity and offering potential to design new putative cancer immunotherapies and vacci
Autor:
Sonia Ghilas, Dinesh Raghu, Kelly Tran, Yang Liao, Bhupinder Pal, Shoukat Sterle, Christine Dijkstra, Marina Yakou, Pavitha Parathan, John Mariadason, Matthias Ernst, Andreas Behren, Grant Drummond, Wei Shi, Lisa A. Mielke
Publikováno v:
Cancer Research. 82:PR007-PR007
Homeostasis in the gut is achieved by impeccable functioning of tissue resident immune cells that reside and closely interact with the epithelium. The tissue resident immune cells of the intestinal epithelium are predominantly lymphocytes, known as i