Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lisa A Freeburg"'
Autor:
Stephanie L Samani, Shayne C Barlow, Lisa A Freeburg, Traci L Jones, Marlee Poole, Mark A Sarzynski, Michael R Zile, Tarek Shazly, Francis G Spinale
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0292243 (2024)
BackgroundStandardized exercise protocols have been shown to improve overall cardiovascular fitness, but direct effects on left ventricular (LV) function, particularly diastolic function and relation to post-transcriptional molecular pathways (microR
Externí odkaz:
https://doaj.org/article/f0f0cf33b3ec4f5286355ca0b5c3e294
Autor:
Yimu Lai, Heather Doviak, Valerie K. Laney, Lisa A. Freeburg, Kia N. Zellars, Laura B. Snyder, Francis G. Spinale, Lydia E. Matesic, Amber Moore
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 321:H976-H984
Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and is accompanied by abnormal extracellular matrix (ECM) accumulation. It is now recognized that the ECM is a dy
Autor:
Nicole Guerrera, Francis G. Spinale, Lawrence H. Young, Caroline J. Zeiss, Daniel Pfau, Abigail C. Hoenes, Nabil E. Boutagy, Lisa A. Freeburg, Sydney J. Womack, Albert J. Sinusas, Attila Feher, Zhao Liu
Publikováno v:
JACC: CardioOncology. 2:774-787
Background Doxorubicin (DOX) induces cardiotoxicity in part by activation of matrix metalloproteinases (MMPs). Sacubitril/valsartan (Sac/Val) exerts additive cardioprotective actions over ...
Autor:
Kia N. Zellars, Eva Romito, Heather Doviak, Tae-Weon Lee, Gregory L. Brower, Parker D. Freels, Stephen W. Smith, David C Lobb, James A Shuman, Lisa A. Freeburg, Francis G. Spinale, Aarif Y. Khakoo, Jason W. O’Neill
Publikováno v:
J Pharmacol Exp Ther
Infarct expansion can occur after myocardial infarction (MI), which leads to adverse left ventricular (LV) remodeling and failure. An imbalance between matrix metalloproteinase (MMP) induction and tissue inhibitors of MMPs (TIMPs) can accelerate this
Autor:
Heather Doviak, Amber Moore, William M. Torres, Michael R. Zile, Abigail C. Hoenes, Shayne C. Barlow, Lisa A. Freeburg, Tarek Shazly, Francis G. Spinale
Publikováno v:
JACC: Basic to Translational Science. 5:463-480
Summary This study assessed the regional changes in myocardial geometry, microstructure, mechanical behavior, and properties that occur in response to progressive left ventricular pressure overload (LVPO) in a large animal model. Using an index of lo
Autor:
Laura B, Snyder, Yimu, Lai, Heather, Doviak, Lisa A, Freeburg, Valerie K, Laney, Amber, Moore, Kia N, Zellars, Lydia E, Matesic, Francis G, Spinale
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 321(5)
Heart failure with a preserved left ventricular (LV) ejection fraction (HFpEF) often arises from a prolonged LV pressure overload (LVPO) and accompanied by abnormal extracellular matrix (ECM) accumulation. The E
Autor:
Bryan D. Young, Hannah Moreland, Zartashia Shahab, Erica L. Herzog, Francis G. Spinale, Lisa A. Freeburg, Edward J. Miller, Kelsie E. Oatmen
Publikováno v:
International heart journal. 62(5)
While cardiac imaging has improved the diagnosis and risk assessment for cardiac sarcoidosis (CS), treatment regimens have consisted of generalized heart failure therapies and non-specific anti-inflammatory regimens. The overall goal of this study wa
Autor:
Edie C. Goldsmith, Amber Moore, Kia N. Zellars, Lisa A. Freeburg, Laura Snyder, Paige E. Perreault, Lauren-Ashley Michelle Duncan, Lydia E. Matesic, Francis G. Spinale
Publikováno v:
Am J Physiol Heart Circ Physiol
Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular hypertrophy (LVH) commonly occurs as a function of age and can cause heart failure (HF) with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22fe00ed8d17b7a3f10fb5b0e3a7153
https://europepmc.org/articles/PMC7717125/
https://europepmc.org/articles/PMC7717125/
Autor:
Heather Doviak, Abigail Hoenes, Aarif Y. Khakoo, Jason A. Burdick, Kia N. Zellars, Julia Jacobs, Lisa A. Freeburg, Francis G. Spinale, Shayne C. Barlow, Brendan P. Purcell, TaeWeon Lee, Paige E. Perreault
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 315(4)
Although improvements in timing and approach for early reperfusion with acute coronary syndromes have occurred, myocardial injury culminating in a myocardial infarction (MI) remains a common event. Although a multifactorial process, an imbalance betw
Autor:
Lisa A. Freeburg, Camila F. Villacreses, Stephen Smith, TaeWeon Lee, Aarif Y. Khakoo, Julia Jacobs, Heather Doviak, Shayne C. Barlow, Kia N. Zellars, Karen Moreau, Paige E Perreault, Francis G. Spinale
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 313(4)
Ischemia-reperfusion (IR) and myocardial infarction (MI) cause adverse left ventricular (LV) remodeling and heart failure and are facilitated by an imbalance in matrix metalloproteinase (MMP) activation and the endogenous tissue inhibitors of metallo