Výsledky vyhledávání - "Lisa Sherman"

Publikováno v: Teaching Children Mathematics. 24:154-157

NCTM's Principles to Actions: Ensuring Mathematical Success for All outlines eight mathematics teaching practices for effective teaching and learning of mathematics (NCTM 2014, p. 10). The second practice, Implement tasks that promote reasoning and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21f0bd5fb1e8066aa0c1f521bfe72174
https://doi.org/10.5951/teacchilmath.24.3.0154

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Identification of triazolopyridazinones as potent p38α inhibitors

Autor: Claire L. M. Jackson, Bradley Henkle, Matthew R. Lee, Brad Herberich, Andrew Tasker, Samer Chmait, Qiurong Liu, Christiaan J. M. Saris, Faye Hsieh, Liping H. Pettus, Christopher Mohr, Lisa Sherman, Ryan Wurz, Lu Min Wong

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:1226-1229

Structure-activity relationship (SAR) investigations of a novel class of triazolopyridazinone p38α mitogen activated protein kinase (MAPK) inhibitors are disclosed. From these studies, increased in vitro potency was observed for 2,6-disubstituted ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9647181f2f2fd256c513ab351fdba20b
https://doi.org/10.1016/j.bmcl.2011.11.067

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3-Amino-7-phthalazinylbenzoisoxazoles as a Novel Class of Potent, Selective, and Orally Available Inhibitors of p38α Mitogen-Activated Protein Kinase

Publikováno v: Journal of Medicinal Chemistry. 51:6280-6292

The p38 mitogen-activated protein kinase (MAPK) is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a variety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7087b9c4f5722d23b003b38ab86133ff
https://doi.org/10.1021/jm8005405

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[Untitled]

Autor: Glenda Revelle, Lisa Sherman, Juan Pablo Hourcade, Michele Platner, Allison Druin, Ben Bederson

Publikováno v: Journal of Science Education and Technology. 11:49-57

This paper reports on the development of a visual search interface (called “SearchKids”) to support children ages 5–10 years in their efforts to find animals in a hierarchical information structure. This search tool presents both the querying p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b935045154aa175521ca6d8b19388b1
https://doi.org/10.1023/a:1013947430933

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Predictability of peripheral lymphocyte reduction of novel S1P1 agonists by in vitro GPCR signaling profile

Autor: Yang Xu, Mike Fiorino, Elizabeth Tominey, Min Wong, Lisa Sherman, Victor J. Cee, Roland Burli, Brad Henkle, Han Xu, Jerry Siu, Keith Kelley, Matt Adlam, Michele McElvain

Publikováno v: Journal of biomolecular screening. 18(9)

Surrogate readouts of G-protein-coupled receptor signaling pathways using highly engineered systems are often employed in the drug discovery process. However, accumulating data have demonstrated the importance of selecting relevant biological activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::603ba7984cf81c79f7957f8df7df0d1a
https://pubmed.ncbi.nlm.nih.gov/23686102

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Discovery of pyridazinopyridinones as potent and selective p38 mitogen-activated protein kinase inhibitors

Autor: Faye Hsieh, Elizabeth M. Doherty, Bradley Henkle, Helen J. McBride, Lisa Sherman, Lu Min Wong, Andrew Tasker, Matthew R. Lee, Christiaan J. M. Saris, Matthew H. Plant, Bin Wu, Liping H. Pettus, Hui-Ling Wang, Ryan Wurz

Publikováno v: Journal of medicinal chemistry. 53(17)

The p38 mitogen-activated protein kinase (MAPK) plays an important role in the production of proinflammatory cytokines, making it an attractive target for the treatment of various inflammatory diseases. A series of pyridazinopyridinone compounds were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efcedb28e563a4aaad90be4ae67924d
https://pubmed.ncbi.nlm.nih.gov/20712346

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Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase

Autor: Liping H, Pettus, Ryan P, Wurz, Shimin, Xu, Brad, Herberich, Bradley, Henkle, Qiurong, Liu, Helen J, McBride, Sharon, Mu, Matthew H, Plant, Christiaan J M, Saris, Lisa, Sherman, Lu Min, Wong, Samer, Chmait, Matthew R, Lee, Christopher, Mohr, Faye, Hsieh, Andrew S, Tasker

Publikováno v: Journal of medicinal chemistry. 53(7)

The p38alpha mitogen-activated protein (MAP) kinase is a central signaling molecule in many proinflammatory pathways, regulating the cellular response to a multitude of external stimuli including heat, ultraviolet radiation, osmotic shock, and a vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70a8588035612689d1c02ad6415d9e18
https://pubmed.ncbi.nlm.nih.gov/20218619

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Part 2: Structure-activity relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase

Autor: Ryan P. Wurz, Liping H. Pettus, Bradley Henkle, Lisa Sherman, Matthew Plant, Kent Miner, Helen J. McBride, Lu Min Wong, Christiaan J.M. Saris, Matthew R. Lee, Samer Chmait, Christopher Mohr, Faye Hsieh, Andrew S. Tasker

Publikováno v: Bioorganicmedicinal chemistry letters. 20(5)

A novel class of pyrazolopyridazine p38alpha mitogen-activated protein kinase (MAPK) inhibitors is disclosed. A structure activity relationship (SAR) investigation was conducted driven by the ability of these compounds to inhibit the p38alpha enzyme,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2906e3074f6867c308cf5e4c2b1a9be
https://pubmed.ncbi.nlm.nih.gov/20138761

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Part 1: Structure-Activity Relationship (SAR) investigations of fused pyrazoles as potent, selective and orally available inhibitors of p38alpha mitogen-activated protein kinase

Autor: Samer Chmait, Lu Min Wong, Faye Hsieh, Liping H. Pettus, Ryan Wurz, Andrew Tasker, Lisa Sherman, Matthew R. Lee, Kent Miner, Helen J. McBride, Matthew H. Plant, Shimin Xu, Christiaan J. M. Saris, Christopher Mohr, Bradley Henkle

Publikováno v: Bioorganicmedicinal chemistry letters. 19(16)

A novel class of pyrazolopyridazine p38α mitogen-activated protein kinase (MAPK) inhibitors is disclosed. A structure activity relationship (SAR) investigation was conducted driven by the ability of these compounds to inhibit the p38α enzyme, the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd51e2be792e935e554fc47693b7163f
https://pubmed.ncbi.nlm.nih.gov/19574047

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