Metformin selectively targets redox control of complex I energy transduction

Autor: Amy R. Cameron, Lisa Logie, Kashyap Patel, Stefan Erhardt, Sandra Bacon, Paul Middleton, Jean Harthill, Calum Forteath, Josh T. Coats, Calum Kerr, Heather Curry, Derek Stewart, Kei Sakamoto, Peter RepiÅ¡Äák, Martin J. Paterson, Ilmo Hassinen, Gordon McDougall, Graham Rena

Publikováno v: Redox Biology, Vol 14, Iss , Pp 187-197 (2018)

Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that

Externí odkaz: https://doaj.org/article/4594871bfca64daf88a105477355aaec

Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

Autor: Gordon J. McDougall, Kei Sakamoto, Benoit Viollet, Calum Forteath, Lisa Logie, Jean Harthill, Amy R. Cameron, Marc Foretz, Kashyap A. Patel, Derek Stewart, Adam J. Roberts, Sandra Bacon, Graham Rena, Calum Sutherland

Publikováno v: Biochimica et Biophysica Acta

Anti-hyperglycaemic effects of the hydroxybenzoic acid salicylate might stem from effects of the drug on mitochondrial uncoupling, activation of AMP-activated protein kinase, and inhibition of NF-κB signalling. Here, we have gauged the contribution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7f385c8a609a19af41fff623f67352

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

Autor: Kathleen M. Giacomini, Adriaan Kooy, Coen D.A. Stehouwer, MetGen Investigators, Valdis Pirags, Daniel M. Rotroff, Ivan Tkáč, Huan-Chieh Chien, Michael J. Wagner, Shiro Maeda, Federico Innocenti, Joline W.J. Beulens, Monique M. Hedderson, Eric L. Seiser, Sook Wah Yee, Bruno H. Stricker, Accord Investigators, Jozef Židzik, Leen M 't Hart, Rury R. Holman, Alison A. Motsinger-Reif, Jose C. Florez, Albert Hofman, Mattijs Out, Albert M. Levin, Christopher J. Groves, Michiaki Kubo, Longyang Wu, Catherine E. de Keyser, Ewan R. Pearson, Lisa Logie, Calum Sutherland, Sabina Semiz, Tanja Dujic, John S. Witte, Amanda J. Bennett, Kathleen A. Jablonski, Linda Zaharenko, Nienke van Leeuwen, Ling Chen, Dpp Investigators, Roger Tavendale, Ruth L. Coleman, Amber A. van der Heijden, Colin N. A. Palmer, Janis Klovins, Martin Javorský, Ron H.N. van Schaik, Mark I. McCarthy, L. Keoki Williams, Kaixin Zhou

Publikováno v: Nature Genetics, 48(9), 1055
Nature Genetics, 48(9), 1055-+. Nature Publishing Group
Nature Genetics, 48(9), 1055-1059. Nature Publishing Group
Zhou, K, Yee, S W, Seiser, E L, van Leeuwen, N, Tavendalel, R, Bennett, A J, Groves, C J, Coleman, R L, van der Heijden, A A, Beulens, J W, de Keyser, C E, Zaharenkoll, L, Rotroff', D M, Out, M, Jablonski, K A, Chen, L, Javorsky, M, Zidzik, J, Levin, A M, Williams, L K, Dujic, T, Semiz, S, Kubo, M, Chien, H-C, Maeda, S, Witte, J S, Wu, L, Tkac, I, Kooy, A, van Schaik, R H N, Stehouwer, C D A, Logie, L, Sutherland, C, Klovins, J, Pirags, V, Hofman, A, Stricker, B H, Motsinger-Reif, A A, Wagner, M J, Innocenti, F, Hart, L M, Holman, R R, McCarthy, M I, Hedderson, M M, Palmer, C N A, Florez, J C, Giacomini, K M & Pearson, E R 2016, ' Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin ', Nature Genetics, vol. 48, no. 9, pp. 1055-1059 . https://doi.org/10.1038/ng.3632

Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear(1). Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consistin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d8e457d5e17ebbdb7b48c533893063
https://hdl.handle.net/1887/96245

Cellular Responses to the Metal-Binding Properties of Metformin

Autor: Alan R. Prescott, Sandra Bacon, Lin Xue, Kashyap A. Patel, Lisa Logie, Kei Sakamoto, Hua Jiang, Katherine Macrae, Huan-Huan Wang, Graham Rena, Jean Harthill, D. Lee Hamilton, Gordon J. McDougall

Publikováno v: Diabetes

In recent decades, the antihyperglycemic biguanide metformin has been used extensively in the treatment of type 2 diabetes, despite continuing uncertainty over its direct target. In this article, using two independent approaches, we demonstrate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f6c6521f12b444d3216d388b24f155
https://doi.org/10.2337/db11-0961

Generation, validation and humanisation of a novel insulin resistant cell model

Autor: Giora Feuerstein, Christal Grierson, Daniel Crowther, Anna M. Tommasi, Bridget Shepherd, Andrew D. Morris, Ewan R. Pearson, Lisa Logie, Antonio J. Ruiz-Alcaraz, Calum Sutherland, Jeffrey Brady, Michael K. Hansen, Christopher Schofield, H. S. Hundal

Publikováno v: Biochemical Pharmacology. 80:1042-1049

Insulin resistance is a characteristic of type 2 diabetes and is a major independent risk factor for progression to the disease. In particular, insulin resistance associates with increased body fat and almost certainly contributes to the dramatic inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bc5a21ec38fc8e65116cdcdaa7128f6
https://doi.org/10.1016/j.bcp.2010.06.011