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pro vyhledávání: '"Lisa Hendry"'
Publikováno v:
King's College London
STAT (signal transducer and activator of transcription) proteins are critical regulators of cytokine-induced cell proliferation, differentiation and survival. STAT functional activity can be variably regulated by post-translational modifications, inc
Autor:
Sean Whittaker, Machteld M. Tiemessen, Lisa Hendry, Leonie S. Taams, Susan D. John, Tracey J. Mitchell
Publikováno v:
Journal of Investigative Dermatology. 126:2217-2223
Mycosis fungoides and its leukemic variant, Sezary syndrome, are the most common primary cutaneous T-cell lymphomas (CTCLs). In an ex vivo study, we investigated the percentage, phenotype, and suppressive function of CD4+CD25+ regulatory T cells (Tre
Publikováno v:
Journal of Biological Chemistry. 279:18998-19007
The NH(2) terminus of Stat proteins forms a versatile protein interaction domain that is believed to use discrete surfaces to mediate oligomerization and tyrosine dephosphorylation of Stat dimers. Here we show for Stat1 and Stat5a/b that these interf
Autor:
Susan D. John, Lisa Hendry
Publikováno v:
European journal of biochemistry. 271(23-24)
Interaction of cytokines with their cognate receptors leads to the activation of latent transcription factors, the signal transducer and activator of transcription (STAT) proteins. Numerous studies have identified the critical roles played by STAT pr