Copper Induces Protein Aggregation, a Toxic Process Compensated by Molecular Chaperones

Autor: Lisa Zuily, Nora Lahrach, Rosi Fassler, Olivier Genest, Peter Faller, Olivier Sénèque, Yann Denis, Marie-Pierre Castanié-Cornet, Pierre Genevaux, Ursula Jakob, Dana Reichmann, Marie-Thérèse Giudici-Orticoni, Marianne Ilbert

Publikováno v: mBio, Vol 13, Iss 2 (2022)

ABSTRACT Copper is well known for its antimicrobial and antiviral properties. Under aerobic conditions, copper toxicity relies in part on the production of reactive oxygen species (ROS), especially in the periplasmic compartment. However, copper is s

Externí odkaz: https://doaj.org/article/d2b88acbd8ca489194f154fe226ef8b8

Author response for 'Rational engineering of AA5_2 copper radical oxidases to probe the molecular determinants governing their substrate selectivity'

Autor: null Radka Koncitikova, null Lisa Zuily, null Emeline Lemarié, null David Ribeaucourt, null Safwan Saker, null Mireille Haon, null Harry Brumer, null Victor Guallar, null Jean‐Guy Berrin, null Mickael Lafond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fb2f995e1e6cc720c1b785664af45a0
https://doi.org/10.1111/febs.16713/v2/response1

Interplay between Orientation at Electrodes and Copper Activation of Thermus thermophilus Laccase for O2 Reduction

Autor: David Duché, Elisabeth Lojou, Philippe Parent, Ievgen Mazurenko, Romain Clement, Lisa Zuily, Marianne Ilbert, Vivek Pratap Hitaishi, Ludovica Quattrocchi

Publikováno v: Journal of the American Chemical Society
Journal of the American Chemical Society, 2020, 142 (3), pp.1394-1405. ⟨10.1021/jacs.9b11147⟩
Journal of the American Chemical Society, American Chemical Society, 2020, 142 (3), pp.1394-1405. ⟨10.1021/jacs.9b11147⟩

International audience; Multicopper oxidases (MCOs) catalyze the oxidation of a variety of substrates while reducing oxygen into water through four copper atoms. As an additional feature, some MCOs display an enhanced activity in solution in the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ec674e90d0584ef27e9f998dc87eab
https://doi.org/10.1021/jacs.9b11147