Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lisa, Worrillow"'
Autor:
Matthew A Care, Sharon Barrans, Lisa Worrillow, Andrew Jack, David R Westhead, Reuben M Tooze
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55895 (2013)
Cell of origin classification of diffuse large B-cell lymphoma (DLBCL) identifies subsets with biological and clinical significance. Despite the established nature of the classification existing studies display variability in classifier implementatio
Externí odkaz:
https://doaj.org/article/4a1103cd6bd94c148f4d5e57f3935591
Autor:
Simon Crouch, Penny Wright, Jenny Buxton, Nicholas Francis Grigoropoulos, Ming-Qing Du, Bridget S. Wilkins, Yuanxue Huang, Andrew Jack, A. James Watkins, Michael J. Neat, Paul Fields, Lisa Worrillow, Sharon Barrans, Peter Johnson, Sylvia Kocialkowski, Hongxiang Liu, Alexandra Clipson, Eve Roman, Hesham EI‐Daly, John R. Goodlad, George A Follows, John W Grant, Ming Wang, Naiyan Zeng
Publikováno v:
The Journal of Pathology: Clinical Research. 1:125-133
A proportion of MYC translocation positive diffuse large B-cell lymphomas (DLBCL) harbour a BCL2 and/or BCL6 translocation, known as double-hit DLBCL, and are clinically aggressive. It is unknown whether there are other genetic abnormalities that coo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27b9777ee0826cc1e44a266941a0d9ba
https://doi.org/10.1002/cjp2.10
https://doi.org/10.1002/cjp2.10
Autor:
Reuben Tooze, Paul Evans, Peter Hillmen, Praveen Baskaran, Darren J. Newton, Sheila J.M. O’Connor, Lisa Worrillow, Andy C. Rawstron, Talha Munir, Abraham M. Varghese, Matthew A. Care, Lee Hazelwood
Chronic lymphocytic leukaemia (CLL) is the most common clonal B-cell disorder characterized by clonal diversity, a relapsing and remitting course, and in its aggressive forms remains largely incurable. Current front-line regimes include agents such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba773712385a98525f7e953ef0a9a37
https://eprints.whiterose.ac.uk/96412/1/TP_53finalsubmitted.pdf
https://eprints.whiterose.ac.uk/96412/1/TP_53finalsubmitted.pdf
Autor:
Nicola J. Sunter, Simon Bomken, David Grimwade, Sheila Taylor, Graham Jackson, Gail Jones, James M. Allan, Victoria J. Forster, Sarah E. Fordham, Lisa Worrillow, Kathryn Scott, Robert Kerrin Hills
Publikováno v:
Blood. 119:196-205
Up to 15% of acute promyelocytic leukemia (APL) patients fail to achieve or maintain remission. We investigated a common G > A polymorphism at position −1377 (rs2234767) in the core promoter of the CD95 cell death receptor gene in 708 subjects with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438ace40c2e089abce0a144065d69d61
https://doi.org/10.1182/blood-2011-04-349803
https://doi.org/10.1182/blood-2011-04-349803
Autor:
Hans H. Storm, P R Taylor, Graham Jackson, Graça M. Dores, James M. Allan, Martin Andersson, Lois B. Travis, Gareth J. Morgan, Bengt Glimelius, Charles F. Lynch, Kathryn Scott, Alexandra Smith, Eleanor V. Willett, Lisa Worrillow, Eero Pukkala, Mogens Vyberg, D Scott, Gail Jones, Eric J. Holowaty, A J Ashcroft
Publikováno v:
Worrillow, L J, Smith, A G, Scott, K, Andersson, M, Ashcroft, A J, Dores, G M, Glimelius, B, Holowaty, E, Jackson, G H, Jones, G L, Lynch, C F, Morgan, G, Pukkala, E, Scott, D, Storm, H H, Taylor, P R, Vyberg, M, Willett, E, Travis, L B & Allan, J M 2008, ' Polymorphic MLH1 and risk of cancer after methylating chemotherapy for Hodgkin lymphoma ', Journal of Medical Genetics, vol. 45, no. 3, pp. 142-6 . https://doi.org/10.1136/jmg.2007.053850
Udgivelsesdato: 2008-Mar BACKGROUND AND OBJECTIVE: Methylating agents are effective chemotherapy agents for Hodgkin lymphoma, but are associated with the development of second primary cancers. Cytotoxicity of methylating agents is mediated primarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2422ccf7fa0da001005e66523d42d1
https://doi.org/10.1136/jmg.2007.053850
https://doi.org/10.1136/jmg.2007.053850
Autor:
Yuanxue Huang, Tim Forshew, Jing Su, Sarah Moody, Alexandra Clipson, Leire Escudero-Ibarz, Nicholas Francis Grigoropoulos, Xuemin Xue, Kim Brügger, Ming-Qing Du, Andrew Jack, Naiyan Zeng, Lisa Worrillow, Ming Wang, Sharon Barrans, Andrew E. Firth, Howard Martin
Publikováno v:
The Journal of molecular diagnostics : JMD. 17(5)
High-throughput somatic mutation screening using FFPE tissues is a major challenge because of a lack of established methods and validated variant calling algorithms. We aimed to develop a targeted sequencing protocol by Fluidigm multiplex PCR and Ill
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1624e7bf0ea05ac76b94ff38b35b2f38
https://pubmed.ncbi.nlm.nih.gov/26165823
https://pubmed.ncbi.nlm.nih.gov/26165823
Autor:
Lisa Worrillow, James M. Allan
Publikováno v:
Oncogene. 25:1709-1720
Chemotherapeutic regimes involving alkylating agents, such as methylators and crosslinking nitrogen mustards, represent a major risk factor for acute myeloid leukaemia. A high frequency of microsatellite instability and evidence of MSH2 loss in alkyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d615b7ee8ecb5fa69b98f3c4634f75
https://doi.org/10.1038/sj.onc.1209208
https://doi.org/10.1038/sj.onc.1209208
Autor:
Alexandra, Clipson, Sharon, Barrans, Naiyan, Zeng, Simon, Crouch, Nicholas F, Grigoropoulos, Hongxiang, Liu, Sylvia, Kocialkowski, Ming, Wang, Yuanxue, Huang, Lisa, Worrillow, John, Goodlad, Jenny, Buxton, Michael, Neat, Paul, Fields, Bridget, Wilkins, John W, Grant, Penny, Wright, Hesham, Ei-Daly, George A, Follows, Eve, Roman, A James, Watkins, Peter W M, Johnson, Andrew, Jack, Ming-Qing, Du
Publikováno v:
The Journal of Pathology: Clinical Research
A proportion of MYC translocation positive diffuse large B‐cell lymphomas (DLBCL) harbour a BCL2 and/or BCL6 translocation, known as double‐hit DLBCL, and are clinically aggressive. It is unknown whether there are other genetic abnormalities that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7bececa058f08f2d66fdbf4d9ca584b
https://pubmed.ncbi.nlm.nih.gov/27347428
https://pubmed.ncbi.nlm.nih.gov/27347428
Autor:
Russell Patmore, David R. Westhead, Simon Crouch, Eve Roman, Andrew Jack, Reuben Tooze, Lisa Worrillow, Matthew A. Care, Sharon Barrans, Alex Smith
Publikováno v:
British journal of haematology. 159(4)
This study tested the validity of whole-genome expression profiling (GEP) using RNA from formalin-fixed, paraffin-embedded (FFPE) tissue to sub-classify Diffuse Large B-cell Lymphoma (DLBCL), in a population based cohort of 172 patients. GEP was perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8d528891c282916be7d6a4ae09224d
https://pubmed.ncbi.nlm.nih.gov/22970711
https://pubmed.ncbi.nlm.nih.gov/22970711
Autor:
Ann M. Dring, Gareth J. Morgan, Lisa Worrillow, James M. Allan, Faith E. Davies, Philippa L. Roddam
Publikováno v:
British journal of haematology. 149(2)
Repair of DNA strand breaks induced during lymphoid antigen receptor rearrangement involves non-homologous end-joining (NHEJ). We investigated NHEJ in the aetiology of lymphoproliferative disorders (LPDs) and the disease subtypes therein through real
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59bf3c5f17a98106b4da419cc24a3740
https://pubmed.ncbi.nlm.nih.gov/20148879
https://pubmed.ncbi.nlm.nih.gov/20148879