Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Lisa, Rahbaek"'
Autor:
Jill Hallin, Vickie Bowcut, Andrew Calinisan, David M. Briere, Lauren Hargis, Lars D. Engstrom, Jade Laguer, James Medwid, Darin Vanderpool, Ella Lifset, David Trinh, Natalie Hoffman, Xiaolun Wang, J. David Lawson, Robin J. Gunn, Christopher R. Smith, Nicole C. Thomas, Matthew Martinson, Alex Bergstrom, Francis Sullivan, Karyn Bouhana, Shannon Winski, Leo He, Julio Fernandez-Banet, Adam Pavlicek, Jacob R. Haling, Lisa Rahbaek, Matthew A. Marx, Peter Olson, James G. Christensen
Publikováno v:
Nature Medicine. 28:2171-2182
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d677a7e099fb8459d3aaad7bbf29b468
https://doi.org/10.1038/s41591-022-02007-7
https://doi.org/10.1038/s41591-022-02007-7
Autor:
John M. Ketcham, Jacob Haling, Shilpi Khare, Vickie Bowcut, David M. Briere, Aaron C. Burns, Robin J. Gunn, Anthony Ivetac, Jon Kuehler, Svitlana Kulyk, Jade Laguer, J. David Lawson, Krystal Moya, Natalie Nguyen, Lisa Rahbaek, Barbara Saechao, Christopher R. Smith, Niranjan Sudhakar, Nicole C. Thomas, Laura Vegar, Darin Vanderpool, Xiaolun Wang, Larry Yan, Peter Olson, James G. Christensen, Matthew A. Marx
Publikováno v:
Journal of Medicinal Chemistry. 65:9678-9690
SOS1 is one of the major guanine nucleotide exchange factors that regulates the ability of KRAS to cycle through its "on" and "off" states. Disrupting the SOS1:KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe52dccfc91d77da8d18ff2be215969
https://doi.org/10.1021/acs.jmedchem.2c00741
https://doi.org/10.1021/acs.jmedchem.2c00741
Autor:
Christopher R. Smith, Ruth Aranda, Thomas P. Bobinski, David M. Briere, Aaron C. Burns, James G. Christensen, Jeffery Clarine, Lars D. Engstrom, Robin J. Gunn, Anthony Ivetac, Ronald Jean-Baptiste, John M. Ketcham, Masakazu Kobayashi, Jon Kuehler, Svitlana Kulyk, J. David Lawson, Krystal Moya, Peter Olson, Lisa Rahbaek, Nicole C. Thomas, Xiaolun Wang, Laura M. Waters, Matthew A. Marx
Publikováno v:
Journal of Medicinal Chemistry. 65:1749-1766
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6807ba018e034c41898a959b92d453dc
https://doi.org/10.1021/acs.jmedchem.1c01900
https://doi.org/10.1021/acs.jmedchem.1c01900
Autor:
Xiaolun Wang, Shelley Allen, James F. Blake, Vickie Bowcut, David M. Briere, Andrew Calinisan, Joshua R. Dahlke, Jay B. Fell, John P. Fischer, Robin J. Gunn, Jill Hallin, Jade Laguer, J. David Lawson, James Medwid, Brad Newhouse, Phong Nguyen, Jacob M. O’Leary, Peter Olson, Spencer Pajk, Lisa Rahbaek, Mareli Rodriguez, Christopher R. Smith, Tony P. Tang, Nicole C. Thomas, Darin Vanderpool, Guy P. Vigers, James G. Christensen, Matthew A. Marx
Publikováno v:
Journal of Medicinal Chemistry. 65:3123-3133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a806650aaec5c7d35ae8ff6555c3535
https://doi.org/10.1021/acs.jmedchem.1c01688
https://doi.org/10.1021/acs.jmedchem.1c01688
Autor:
Donavon McConn, Betty Lam, Victoria J Mulligan, Nicola Brice, Hans H Schiffer, Holger Monenschein, Stephen Hitchcock, Holly Reichard, Nidhi Kaushal, Deanna R Collia, Philip L R Gaskin, Jordi Serrats, Alejandro Amador-Arjona, William J. Ray, Jackie Cilia, Joshua Bliesath, Alton W Skaggs, Josephine Atienza, Gerard Corbett, Lisa Rahbaek
Publikováno v:
Journal of Medicinal Chemistry. 64:11527-11542
The orphan G-protein-coupled receptor GPR139 is highly expressed in the habenula, a small brain nucleus that has been linked to depression, schizophrenia (SCZ), and substance-use disorder. High-throughput screening and a medicinal chemistry structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a84831e89c5ddec9daf9e358ecd6b5b6
https://doi.org/10.1021/acs.jmedchem.1c00820
https://doi.org/10.1021/acs.jmedchem.1c00820
Autor:
James Christensen, Jill Hallin, Vickie Bowcut, Andrew Calinisan, David Briere, Lauren Hargis, Lars Engstrom, Jade Laguer, James Medwid, Darin Vanderpool, Ella Lifset, David Trinh, Natalie Hoffman, Xiaolun Wang, J. Lawson, Robin Gunn, Christopher Smith, Nicole Thomas, Matthew Martinson, Alex Bergstrom, Francis Sullivan, Karyn Bouhana, Shannon Winski, Leo He, Fernandez-Banet Julio, Adam Pavlicek, Jacob Haling, Lisa Rahbaek, Matthew Marx, Peter Olson
The ability to effectively target mutated KRAS has remained elusive despite decades of research. The recent identification of KRASG12C inhibitors has provided an effective treatment option for patients harboring this particular mutation and has also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10fbcfa8cb41321f46bb73555a3d1e2c
https://doi.org/10.21203/rs.3.rs-1261963/v1
https://doi.org/10.21203/rs.3.rs-1261963/v1
Autor:
Christopher R, Smith, Ruth, Aranda, Thomas P, Bobinski, David M, Briere, Aaron C, Burns, James G, Christensen, Jeffery, Clarine, Lars D, Engstrom, Robin J, Gunn, Anthony, Ivetac, Ronald, Jean-Baptiste, John M, Ketcham, Masakazu, Kobayashi, Jon, Kuehler, Svitlana, Kulyk, J David, Lawson, Krystal, Moya, Peter, Olson, Lisa, Rahbaek, Nicole C, Thomas, Xiaolun, Wang, Laura M, Waters, Matthew A, Marx
Publikováno v:
Journal of medicinal chemistry. 65(3)
The PRMT5•MTA complex has recently emerged as a new synthetically lethal drug target for the treatment of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d6afde10fb43fd4032bf2afa3ede5ca
https://pubmed.ncbi.nlm.nih.gov/35041419
https://pubmed.ncbi.nlm.nih.gov/35041419
Autor:
Jill, Hallin, Vickie, Bowcut, Andrew, Calinisan, David M, Briere, Lauren, Hargis, Lars D, Engstrom, Jade, Laguer, James, Medwid, Darin, Vanderpool, Ella, Lifset, David, Trinh, Natalie, Hoffman, Xiaolun, Wang, J, David Lawson, Robin J, Gunn, Christopher R, Smith, Nicole C, Thomas, Matthew, Martinson, Alex, Bergstrom, Francis, Sullivan, Karyn, Bouhana, Shannon, Winski, Leo, He, Julio, Fernandez-Banet, Adam, Pavlicek, Jacob R, Haling, Lisa, Rahbaek, Matthew A, Marx, Peter, Olson, James G, Christensen
Publikováno v:
Nature medicine. 28(10)
Recent progress in targeting KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a7ce4f063fa84ad1780e11dbfbdabc8
https://pubmed.ncbi.nlm.nih.gov/36216931
https://pubmed.ncbi.nlm.nih.gov/36216931
Autor:
Xiaolun, Wang, Shelley, Allen, James F, Blake, Vickie, Bowcut, David M, Briere, Andrew, Calinisan, Joshua R, Dahlke, Jay B, Fell, John P, Fischer, Robin J, Gunn, Jill, Hallin, Jade, Laguer, J David, Lawson, James, Medwid, Brad, Newhouse, Phong, Nguyen, Jacob M, O'Leary, Peter, Olson, Spencer, Pajk, Lisa, Rahbaek, Mareli, Rodriguez, Christopher R, Smith, Tony P, Tang, Nicole C, Thomas, Darin, Vanderpool, Guy P, Vigers, James G, Christensen, Matthew A, Marx
Publikováno v:
Journal of medicinal chemistry. 65(4)
KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::28a8a679ffc406047b45ef523fe5e8f2
https://pubmed.ncbi.nlm.nih.gov/36284185
https://pubmed.ncbi.nlm.nih.gov/36284185
Autor:
Vickie Bowcut, Andrew Calinisan, David M. Briere, Lauren Hargis, Lars D. Engstrom, Jade Laguer, Darin Vanderpool, Xiaolun Wang, J David Lawson, Nicole Thomas, Robin Gunn, Christopher R. Smith, Julio Fernandez-Banet, Leo He, Adam Pavlicek, Lisa Rahbaek, Matthew A. Marx, Peter Olson, James G. Christensen, Jill Hallin
Publikováno v:
Cancer Research. 82:1131-1131
The ability to effectively target mutated KRAS has remained elusive despite decades of research. Recently, the identification of selective KRASG12C inhibitors has provided an effective treatment option for patients harboring this particular mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b1eca4fb108dd730ff8657fcc5483fc
https://doi.org/10.1158/1538-7445.am2022-1131
https://doi.org/10.1158/1538-7445.am2022-1131