Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lisa, Nogle"'
Autor:
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon Kattar, Ryan W. Chau, Blair T. Lapointe, Joey L. Methot, Duane E. DeMong, Thomas H. Graham, Ravi Kurukulasuriya, Mitchell H. Keylor, Ling Tong, Gregori J. Morriello, John J. Acton, Barbara Pio, Weiguo Liu, Jack D. Scott, Michael J. Ardolino, Theodore A. Martinot, Matthew L. Maddess, Xin Yan, Hakan Gunaydin, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Hongshi Yu, Ellen C. Minnihan, Charles A. Lesburg, Ping Liu, Jing Su, Laxminarayan G. Hegde, Lily Y. Moy, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul Ciaccio, Jennifer A. Piesvaux, Karin M. Otte, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Santhosh Neelamkavil, Harold B. Wood, Peter H. Fuller, J. Michael Ellis
Publikováno v:
Journal of Medicinal Chemistry. 65:16801-16817
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::365ba0e1a6a6d085b4344b637344b726
https://doi.org/10.1021/acs.jmedchem.2c01605
https://doi.org/10.1021/acs.jmedchem.2c01605
Autor:
Anandan Palani, Matthew Lloyd Childers, Qinglin Pu, Matthew J. Mitcheltree, Symon Gathiaka, Christian Fischer, Lisa Nogle, Rachel L. Palte, Jared N. Cumming, J. Richard Miller, Spencer McMinn, Hai-Young Kim, Hongjun Zhang, Charles A. Lesburg, Adam Beard, Donovon A. Adpressa, Josep Saurí, Derun Li, Theodore A. Martinot, Thomas W. Lyons, David L. Sloman, Jialiang Wang, Peter Spacciapoli, Min Lu, Abdelghani Achab
Publikováno v:
ACS Med Chem Lett
[Image: see text] Comprehensive synthetic strategies afforded a diverse set of structurally unique bicyclic proline-containing arginase inhibitors with a high degree of three-dimensionality. The analogs that favored the Cγ-exo conformation of the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355a3f9279f9db6a241567d164d50d64
https://doi.org/10.1021/acsmedchemlett.1c00258
https://doi.org/10.1021/acsmedchemlett.1c00258
Autor:
Christopher J. Welch, Shagawa Tomohiro, Kevin Joseph Barry, Mengling Wong, Donghong A. Gao, Iriki Takayuki, Eric T. Manning, Masami Tomita, Nobumitsu Fukushima, Timothy Lee, William Farrell, Benjamin Hritzko, Masayuki Nishimura, Larry Miller, Thomas J. Moran, Robert P. DePianta, Eric P. Seest, Lisa Schaffter, Heewon Lee, Lisa Nogle, Loanne Chung, Yingru Zhang, Katsuhiro Tanaka, Shuping Dong, Michiaki Owa, William Leister, Takeshi Bamba, Meenakshi Goel, Mirlinda Biba, Andy Sasaki, Frank Riley, James Paulson, Douglas B. Moore, Jimmy O. DaSilva, Anne Akin
Publikováno v:
Organic Process Research & Development. 24:1271-1280
Precompetitive collaborations on the development of new enabling technologies for conducting pharmaceutical research and development are becoming increasingly popular as pharmaceutical companies re...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0e811353ecdc232274eff7b85adb75
https://doi.org/10.1021/acs.oprd.0c00136
https://doi.org/10.1021/acs.oprd.0c00136
Autor:
Mitchell H. Keylor, Anmol Gulati, Solomon D. Kattar, Rebecca E. Johnson, Ryan W. Chau, Kaila A. Margrey, Michael J. Ardolino, Cayetana Zarate, Kelsey E. Poremba, Vladimir Simov, Gregori J. Morriello, John J. Acton, Barbara Pio, Xin Yan, Rachel L. Palte, Spencer E. McMinn, Lisa Nogle, Charles A. Lesburg, Donovon Adpressa, Shishi Lin, Santhosh Neelamkavil, Ping Liu, Jing Su, Laxminarayan G. Hegde, Janice D. Woodhouse, Robert Faltus, Tina Xiong, Paul J. Ciaccio, Jennifer Piesvaux, Karin M. Otte, Harold B. Wood, Matthew E. Kennedy, David Jonathan Bennett, Erin F. DiMauro, Matthew J. Fell, Peter H. Fuller
Publikováno v:
Journal of medicinal chemistry. 65(1)
The leucine-rich repeat kinase 2 (LRRK2) protein has been genetically and functionally linked to Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder whose current therapies are limited in scope and efficacy. In this repor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6720c280fccf3e18653a864a196348ad
https://pubmed.ncbi.nlm.nih.gov/34967623
https://pubmed.ncbi.nlm.nih.gov/34967623
Autor:
Sookhee Ha, Nunzio Sciammetta, Graham Smith, Spencer McMinn, Berengere Sauvagnat, Brett A. Hopkins, Hyelee Lee, Lisa Nogle
Publikováno v:
ACS Med Chem Lett
[Image: see text] As more macrocycle structures are utilized to drug intracellular targets, new platforms are needed to facilitate the discovery of cell permeable compounds in this unique chemical space. Herein, a method is disclosed that allows for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5267830998450d6258eb800b78fb6d1e
https://doi.org/10.1021/acsmedchemlett.9b00036
https://doi.org/10.1021/acsmedchemlett.9b00036
Autor:
Anand Palani, Min Lu, Jennifer O'Neil, Christopher Brynczka, Lisa Nogle, Amy C. Doty, Christian Fischer, Hai-Young Kim, Abdelghani Achab, Adam Beard, Nicole C. Walsh, Matthew Lloyd Childers, Kalyan Chakravarthy, Josep Saurí, Amy D. DeCastro, Peter W. Fan, Qinglin Pu, Richard A. Miller, Matthew J. Mitcheltree, Rachel L. Palte, Theodore A. Martinot, Hongjun Zhang, Symon Gathiaka, Roshi Afshar, Thomas W. Lyons, Spencer McMinn, Mangeng Cheng, Derun Li
Publikováno v:
Cancer Research. 81:297-297
Arginase overexpression has been associated with poor survival rates in advanced cancer patients treated with Keytruda. High levels of Arginase may lead to a depletion of arginine within the tumor microenvironment, inhibiting the immune response. Thu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd9e5ec9e0fbb0441a0d7aebfe3cfa7c
https://doi.org/10.1158/1538-7445.am2021-297
https://doi.org/10.1158/1538-7445.am2021-297
Autor:
Christopher J. Welch, Lisa Nogle, Brandyce Coes, Ray T. McClain, Ingrid Mergelsberg, Lisa F. Frey, Jimmy O. DaSilva
Publikováno v:
Journal of Chromatography A. 1328:98-103
An evaluation of the use of non-conventional polar modifiers for the supercritical fluid chromatographic separation of enantiomers on immobilized chiral stationary phases is presented. The resolution of a group of nine commercially available racemate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9db532e6142b517a878d8a46586a5ef
https://doi.org/10.1016/j.chroma.2013.12.073
https://doi.org/10.1016/j.chroma.2013.12.073
Publikováno v:
Journal of Separation Science. 31:3698-3703
Recent advances in accurate mass analysis are poised to allow the high-throughput production of accurate mass data on many more compounds than was previously available. It is shown that sub-ppm mass accuracy (producing elemental compositions) can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b996a14ba5f1073805dae4ca78479c
https://doi.org/10.1002/jssc.200800399
https://doi.org/10.1002/jssc.200800399
Publikováno v:
Chirality. 19:716-730
Phenylglycidols substituted in the 2-, 3-, and 4- positions with fluorine, chlorine, and trifluoromethyl, and with methoxy in the 3- position, were synthesized from the corresponding E-cinnamic acids and separated into their (R,R)- and (S,S)- enantio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d18258183f5db79bab821a387b380e
https://doi.org/10.1002/chir.20368
https://doi.org/10.1002/chir.20368
Autor:
Li Di, Leonard A. McDonald, Mairead Young, Lisa Nogle, Dahui Zhou, Brian L. Marquez, Mei-Yi Zhang, William L. Watts, Frank E. Koehn, Alvin C. Bach, Yanxuan Cai, Alan G. Sutherland, Neal Byrne, Guy T. Carter, Michael Z. Kagan, Edward H. Kerns, Mark Tischler, Carl J. Balibar, Oliver J. McConnell, Igor Goljer, Gerhard Schlingmann, Yanan He, Don Herold, Douglas M. Ho, Michael Chlenov, Christopher J. Petucci, R. Thomas Williamson, Gregory J. Tawa, Yingru Zhang, Vasilios Marathias, Christina M. Kraml, Kristi Fan
Publikováno v:
Chirality. 19:658-682
The application of Chiral Technology, or the (extensive) use of techniques or tools for the determination of absolute stereochemistry and the enantiomeric or chiral separation of racemic small molecule potential lead compounds, has been critical to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76974c7b396b4bbc3b5ccb44e18646ca
https://doi.org/10.1002/chir.20399
https://doi.org/10.1002/chir.20399