Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Lisa, Miorin"'
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 114960- (2024)
Summary: Viral infection triggers a rapid and effective cellular response primarily mediated by interferon β (IFNβ), which induces an antiviral state through complex signaling cascades. To maintain a robust antiviral response while preventing exces
Externí odkaz:
https://doaj.org/article/2bfe7e192c4d4676b1f66b6c1d8b8cd2
Autor:
Diego deMiguel‐Perez, Marisol Arroyo‐Hernandez, Sabrina La Salvia, Muthukumar Gunasekaran, Edward M. Pickering, Stephanie Avila, Etse Gebru, Eduardo Becerril‐Vargas, Sergio Monraz‐Perez, Kapil Saharia, Alison Grazioli, Michael T. McCurdy, Matthew Frieman, Lisa Miorin, Alessandro Russo, Andrés F. Cardona, Adolfo García‐Sastre, Sunjay Kaushal, Fred R. Hirsch, Djordje Atanackovic, Susmita Sahoo, Oscar Arrieta, Christian Rolfo
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 11, Pp n/a-n/a (2024)
Abstract The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus disease 2019 (COVID‐19) and has been related to more than 7 million deaths globally since 2019. The association of high levels of IL‐6 with severe ca
Externí odkaz:
https://doaj.org/article/5384e96cf6444786964202fd8fdb4104
Autor:
Baiyu Qiu, Fereshteh Zandkarimi, Anjali Saqi, Candace Castagna, Hui Tan, Miroslav Sekulic, Lisa Miorin, Hanina Hibshoosh, Shinya Toyokuni, Koji Uchida, Brent R. Stockwell
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependen
Externí odkaz:
https://doaj.org/article/527ab259b3444321abb3fec36082bca3
Autor:
Phillip Cohen, Emma J. DeGrace, Oded Danziger, Roosheel S. Patel, Erika A. Barrall, Tesia Bobrowski, Thomas Kehrer, Anastija Cupic, Lisa Miorin, Adolfo García-Sastre, Brad R. Rosenberg
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT Single-cell RNA sequencing (scRNA-Seq) studies have provided critical insight into the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19). scRNA-Seq librar
Externí odkaz:
https://doaj.org/article/088328c0e3864ff1a44427541b806e00
Autor:
Raveen Rathnasinghe, Sonia Jangra, Chengjin Ye, Anastasija Cupic, Gagandeep Singh, Carles Martínez-Romero, Lubbertus C. F. Mulder, Thomas Kehrer, Soner Yildiz, Angela Choi, Stephen T. Yeung, Ignacio Mena, Virginia Gillespie, Jana De Vrieze, Sadaf Aslam, Daniel Stadlbauer, David A. Meekins, Chester D. McDowell, Velmurugan Balaraman, Michael J. Corley, Juergen A. Richt, Bruno G. De Geest, Lisa Miorin, PVI study group, Florian Krammer, Luis Martinez-Sobrido, Viviana Simon, Adolfo García-Sastre, Michael Schotsaert
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Here, Rathnasinghe et al. characterize the pathogenesis of a mouse-adapted SARS-CoV-2 in infected obese and aged mice, and identify mutations that are present in SARS-CoV-2 variants of concern, associated with higher transmissibility.
Externí odkaz:
https://doaj.org/article/12c6e893f2b043239df7246c95215cf6
Autor:
Elisabet Diaz-Beneitez, Liliana Lilibeth Cubas-Gaona, Oscar Candelas-Rivera, Ana Benito-Zafra, Maria Teresa Sánchez-Aparicio, Lisa Miorin, José F. Rodríguez, Adolfo García-Sastre, Dolores Rodríguez
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Infectious Bursal Disease Virus (IBDV) is the causative agent of an immunosuppressive disease that affects domestic chickens (Gallus gallus) severely affecting poultry industry worldwide. IBDV infection is characterized by a rapid depletion of the bu
Externí odkaz:
https://doaj.org/article/fb46bda823d849b8a37de2231d82b00f
Autor:
Raveen Rathnasinghe, Sonia Jangra, Lisa Miorin, Michael Schotsaert, Clifford Yahnke, Adolfo Garcίa-Sastre
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract The germicidal potential of specific wavelengths within the electromagnetic spectrum is an area of growing interest. While ultra-violet (UV) based technologies have shown satisfactory virucidal potential, the photo-toxicity in humans coupled
Externí odkaz:
https://doaj.org/article/8ded076e7f2a4fe8956ddc576a50c68d
Autor:
Víctor Neira, Bárbara Brito, Belén Agüero, Felipe Berrios, Valentina Valdés, Alberto Gutierrez, Naomi Ariyama, Patricio Espinoza, Patricio Retamal, Edward C. Holmes, Ana S. Gonzalez-Reiche, Zenab Khan, Adriana van de Guchte, Jayeeta Dutta, Lisa Miorin, Thomas Kehrer, Nicolás Galarce, Leonardo I. Almonacid, Jorge Levican, Harm van Bakel, Adolfo García-Sastre, Rafael A. Medina
Publikováno v:
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 376-383 (2021)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected in domestic and wild cats. However, little is known about natural viral infections of domestic cats, although their importance for modelling disease spread, informing stra
Externí odkaz:
https://doaj.org/article/ea73f2caf3b04d949acfecff69fc1b95
Autor:
Elena Riera, Daniel Pérez-Núñez, Raquel García-Belmonte, Lisa Miorin, Adolfo García-Sastre, Yolanda Revilla
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
African swine fever virus (ASFV) causes a serious disease in domestic pigs and wild boars and is currently expanding worldwide. No safe and efficacious vaccines against ASFV are available, which threats the swine industry worldwide. African swine fev
Externí odkaz:
https://doaj.org/article/f0c6c3acea7a460593eb2b9dc21ee0c4
Autor:
Khushboo Bafna, Kris White, Balasubramanian Harish, Romel Rosales, Theresa A. Ramelot, Thomas B. Acton, Elena Moreno, Thomas Kehrer, Lisa Miorin, Catherine A. Royer, Adolfo García-Sastre, Robert M. Krug, Gaetano T. Montelione
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109133- (2021)
Summary: Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed 10 hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate bin
Externí odkaz:
https://doaj.org/article/f487dc0be1e94d1382aa92c5a7ce55f1