Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Autor: Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re�

Externí odkaz: https://doaj.org/article/9d3d9f430d2e481298f1f134583ff8b6

Genome annotation improvements from cross-phyla proteogenomics and time-of-day differences in malaria mosquito proteins using untargeted quantitative proteomics.

Autor: Lisa Imrie, Thierry Le Bihan, Áine O'Toole, Paul V Hickner, W Augustine Dunn, Benjamin Weise, Samuel S C Rund

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0220225 (2019)

The malaria mosquito, Anopheles stephensi, and other mosquitoes modulate their biology to match the time-of-day. In the present work, we used a non-hypothesis driven approach (untargeted proteomics) to identify proteins in mosquito tissue, and then q

Externí odkaz: https://doaj.org/article/dbe0168127b1474984b93e5a3f8dc1c8

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

Autor: Max Kotlyar, Priyanka Pillai, Theodosia Charitou, David Matallanas, Victoria Wong, Cinzia Raso, Luis F. Iglesias-Martinez, Colm J. Ryan, Steven Shave, Carlos Herrera-Montavez, Nicola Horn, Ruth Pilkington, Christina Kiel, Layal Dernayka, Miriam A. Lynn, Igor Jurisica, Manuel Bernal-Llinares, Lisa Imrie, Nora Rauch, Franziska Klose, Owen J. Sansom, David J. Lynn, Sriganesh Srihari, Marius Ueffing, Karsten Boldt, Luis Serrano, James Breen, Aleksandar Krstic, Erik Fasterius, Igor Stagljar, Kenneth Bryan, Mohamed Ali Jarboui, Thierry LeBihan, Boris N. Kholodenko, Oleksii S. Rukhlenko, Jasna Curak, Susan Kennedy, Manfred Auer, Cristina Al-Khalili Szigyarto, Walter Kolch, Patrizia Cammareri

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Kennedy, S A, Jarboui, M, Srihari, S, Raso, C, Bryan, K, Dernayka, L, Charitou, T, Bernal-llinares, M, Herrera-montavez, C, Krstic, A, Matallanas, D, Kotlyar, M, Jurisica, I, Curak, J, Wong, V, Stagljar, I, Lebihan, T, Imrie, L, Pillai, P, Lynn, M A, Fasterius, E, Al-khalili Szigyarto, C, Breen, J, Kiel, C, Serrano, L, Rauch, N, Rukhlenko, O, Kholodenko, B N, Iglesias-martinez, L F, Ryan, C J, Pilkington, R, Cammareri, P, Sansom, O, Shave, S, Auer, M, Horn, N, Klose, F, Ueffing, M, Boldt, K, Lynn, D J & Kolch, W 2020, ' Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-019-14224-9
nature.com

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc319b683485723bed6ff60ef6bb1dac
http://link.springer.com/article/10.1038/s41467-019-14224-9

Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy

Autor: David Mellis, Andrea Martello, Domenico D'Arca, Lisa Imrie, Andrea Caporali, Noor Gammoh, John C. Dawson, Elisa Parish, Neil O. Carragher, Nicholas L. Mills, Angela Lauriola, Martina Vidmar, Mairi Brittan, Tijana Mitić

Publikováno v: EMBO Reports
Martello, A, Lauriola, A, Mellis, D, Parish, E, Dawson, J C, Imrie, L, Vidmar, M, Gammoh, N, Mitić, T, Brittan, M, Mills, N L, Carragher, N O, D'arca, D & Caporali, A 2020, ' Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy ', EMBO Reports . https://doi.org/10.15252/embr.201948192

Autophagy is an essential cellular quality control process that has emerged as a critical one for vascular homeostasis. Here, we show that trichoplein (TCHP) links autophagy with endothelial cell (EC) function. TCHP localizes to centriolar satellites

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::252268a62a4ffc2874c85e117a1d5a01
https://hdl.handle.net/11380/1201619

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS

Autor: Susan A, Kennedy, Mohamed-Ali, Jarboui, Sriganesh, Srihari, Cinzia, Raso, Kenneth, Bryan, Layal, Dernayka, Theodosia, Charitou, Manuel, Bernal-Llinares, Carlos, Herrera-Montavez, Aleksandar, Krstic, David, Matallanas, Max, Kotlyar, Igor, Jurisica, Jasna, Curak, Victoria, Wong, Igor, Stagljar, Thierry, LeBihan, Lisa, Imrie, Priyanka, Pillai, Miriam A, Lynn, Erik, Fasterius, Cristina, Al-Khalili Szigyarto, James, Breen, Christina, Kiel, Luis, Serrano, Nora, Rauch, Oleksii, Rukhlenko, Boris N, Kholodenko, Luis F, Iglesias-Martinez, Colm J, Ryan, Ruth, Pilkington, Patrizia, Cammareri, Owen, Sansom, Steven, Shave, Manfred, Auer, Nicola, Horn, Franziska, Klose, Marius, Ueffing, Karsten, Boldt, David J, Lynn, Walter, Kolch

Publikováno v: Nature Communications

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4c4c124719b557c7e00a1b876ae91ba
https://pubmed.ncbi.nlm.nih.gov/31980649