The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol: a multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia [version 2; peer review: 2 approved]

Autor: Albert Koulman, Kelsey Jones, James Berkley, Judd Walson, Eric Houpt, David S. Wishart, Christina L. Lancioni, Moses Ngari, Lei Xia, James M. Njunge, Abdoulaye Hama Diallo, Kirkby Tickell, Md. Amran Gazi, Abu Sadat Mohammad Sayeem Bin Shahid, Zaubina Kazi, Ali Saleem, Caroline Tigoi, Syed Ali, Emily Yoshioka, Ezekiel Mupere, Moses Mburu, Mohammod Jobayer Chisti, Bonface Gichuki, Narshion Ngao, Wilson Gumbi, Elisha Omer, Robert Bandsma, Benson Singa, Wieger Voskuijl, Tahmeed Ahmed, Alex Macharia, Thomas N. Williams, Anna Mitchel, Johnstone Makale, Joe Gogain, Jessica Williams, Rupasri Mandal, Nebojsa Janjic, Michael Routledge, Hang Wu, Camilo Espinosa, Yun Yun Gong, Jie Liu, Nima Aghaeepour, Hilary Browne, Trevor D. Lawley, Doreen Rwigi, Yan Shao, Timothy Kaburu, Kevin Kariuki, Lisa Gartner, Holm H. Uhlig

Publikováno v: Gates Open Research, Vol 6 (2022)

Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest op

Externí odkaz: https://doaj.org/article/4f784e51afb14738813820fdbf1f5a7d

Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999–2019: an epidemiological investigation

Autor: Georg Rieder, Viktoria Ruf, Wolfgang Jilg, Kirsten Utpatel, Matthias Evert, Leonie Forth, Christiane Herden, Barbara Schmidt, Udo Reischl, Jonas Schmidt-Chanasit, Kaspar Matiasek, Christoph Brochhausen, Dennis Rubbenstroth, Andreas Mamilos, Kornelius Fuchs, Jürgen J. Wenzel, Jochen Herms, Dirk Höper, Lisa Gartner, Mario Errath, Sebastian Giese, Tobias Freilinger, Friederike Liesche-Starnecker, Saida Zoubaa, Hans Helmut Niller, Bernd Salzberger, Arnt Ebinger, Ralf A. Linker, Martin Beer, Natalia Velez-Char, Bernhard Neumann, Daniel Nobach, Silke Wunderlich, Jonathan Jantsch, Bernhard Banas, Dennis Tappe, Martin Schwemmle, Klemens Angstwurm, Kore Schlottau, André Gessner, Jürgen Schlegel, Markus J. Riemenschneider, Donata Hoffmann

Publikováno v: The Lancet Infectious Diseases. 20:467-477

Summary Background In 2018–19, Borna disease virus 1 (BoDV-1), the causative agent of Borna disease in horses, sheep, and other domestic mammals, was reported in five human patients with severe to fatal encephalitis in Germany. However, information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9fb61106f7ef4fc092f5ab60700ca5b
https://doi.org/10.1016/s1473-3099(19)30546-8

The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol

Autor: James M. Njunge, Kirkby Tickell, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Md. Amran Gazi, Ali Saleem, Zaubina Kazi, Syed Ali, Caroline Tigoi, Ezekiel Mupere, Christina L. Lancioni, Emily Yoshioka, Mohammod Jobayer Chisti, Moses Mburu, Moses Ngari, Narshion Ngao, Bonface Gichuki, Elisha Omer, Wilson Gumbi, Benson Singa, Robert Bandsma, Tahmeed Ahmed, Wieger Voskuijl, Thomas N. Williams, Alex Macharia, Johnstone Makale, Anna Mitchel, Jessica Williams, Joe Gogain, Nebojsa Janjic, Rupasri Mandal, David S. Wishart, Hang Wu, Lei Xia, Michael Routledge, Yun Yun Gong, Camilo Espinosa, Nima Aghaeepour, Jie Liu, Eric Houpt, Trevor D. Lawley, Hilary Browne, Yan Shao, Doreen Rwigi, Kevin Kariuki, Timothy Kaburu, Holm H. Uhlig, Lisa Gartner, Kelsey Jones, Albert Koulman, Judd Walson, James Berkley

Publikováno v: Gates Open Research, 6:77
Gates Open Research, 6:77. F1000 Research Ltd.
Walson, J, Berkley, J, Njunge, J M, Tickell, K, Diallo, A H, Sayeem Bin Shahid, A S M, Gazi, M A, Saleem, A, Kazi, Z, Ali, S, Tigoi, C, Mupere, E, Lancioni, C L, Yoshioka, E, Chisti, M J, Mburu, M, Ngari, M, Ngao, N, Gichuki, B, Omer, E, Gumbi, W, Singa, B, Bandsma, R, Ahmed, T, Voskuijl, W, Williams, T N, Macharia, A, Makale, J, Mitchel, A, Williams, J, Gogain, J, Janjic, N, Mandal, R, Wishart, D S, Wu, H, Xia, L, Routledge, M, Gong, Y Y, Espinosa, C, Aghaeepour, N, Liu, J, Houpt, E, Lawley, T D, Browne, H, Shao, Y, Rwigi, D, Kariuki, K, Kaburu, T, Uhlig, H H, Gartner, L, Jones, K & Koulman, A 2022, ' The Childhood Acute Illness and Nutrition (CHAIN) network nested case-cohort study protocol : A multi-omics approach to understanding mortality among children in sub-Saharan Africa and South Asia ', Gates Open Research, vol. 6, 77 . https://doi.org/10.12688/gatesopenres.13635.2

Introduction: Many acutely ill children in low- and middle-income settings have a high risk of mortality both during and after hospitalisation despite guideline-based care. Understanding the biological mechanisms underpinning mortality may suggest op

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca2507dc93316c0c7dd8531742d7cbd
http://www.scopus.com/inward/record.url?scp=85141985804&partnerID=8YFLogxK

Functional and structural analysis of cytokine-selective IL6ST defects that cause recessive hyper-IgE syndrome

Autor: Freia Krause, Jessica Gold, Elizabeth A. Worthey, Diane B. Zastrow, Euan A. Ashley, Colleen E. McCormack, Michael D. W. Griffin, Dirk Schmidt-Arras, Michael W. Parker, Arian Laurence, Paul G. Fisher, Christine M. Eng, Stephen B. Montgomery, Veerabahu Shanmugasundaram, Tracy L Putoczki, Yin-Huai Chen, Shruti Marwaha, Lisa Gartner, Riley D. Metcalfe, David P. Bick, Laure Fresard, Yong Huang, Jonathan A. Bernstein, Holm H. Uhlig, Craig J. Morton, Chunli Zhao, Matthew T. Wheeler

Publikováno v: The Journal of allergy and clinical immunology. 148(2)

Background Biallelic variants in IL6ST, encoding GP130, cause a recessive form of hyper-IgE syndrome (HIES) characterized by high IgE level, eosinophilia, defective acute phase response, susceptibility to bacterial infections, and skeletal abnormalit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8add73f9f311480a9bf5ec9e83ad2617
https://pubmed.ncbi.nlm.nih.gov/33771552