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Akademický článek

Nuclear Transport Deficits in Tau-Related Neurodegenerative Diseases

Autor: Lisa Diez, Susanne Wegmann

Publikováno v: Frontiers in Neurology, Vol 11 (2020)

Tau is a cytosolic microtubule binding protein that is highly abundant in the axons of the central nervous system. However, alternative functions of tau also in other cellular compartments are suggested, for example, in the nucleus, where interaction

Externí odkaz: https://doaj.org/article/42b392b818234572a933927268055ef2

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Akademický článek

LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells

Autor: Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Anne Tempelmeier, Christopher Secker, Lisa Diez, Aline Schulz, Konrad Klockmeier, Martina Zenkner, Sabrina Golusik, Kirstin Rau, Sigrid Schnoegl, Craig C Garner, Erich E Wanker

Publikováno v: Molecular Systems Biology, Vol 14, Iss 7, Pp 1-20 (2018)

Abstract Information on protein–protein interactions (PPIs) is of critical importance for studying complex biological systems and developing therapeutic strategies. Here, we present a double‐readout bioluminescence‐based two‐hybrid technology

Externí odkaz: https://doaj.org/article/6a2435b9498b4222843c1f79d478cf6f

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Analysis of Tau/Nucleoporin Interactions by Surface Plasmon Resonance Spectroscopy

Autor: Lisa Diez, Larisa E. Kapinos, Roderick Y. H. Lim, Susanne Wegmann

Publikováno v: New York, NY : Springer US, Methods in Molecular Biology 2551, 95-109 (2023). doi:10.1007/978-1-0716-2597-2_8
Protein Aggregation / Cieplak, Andrzej Stanisław (Editor) ; New York, NY : Springer US, 2023, Chapter 8 ; ISSN: 1064-3745=1940-6029 ; ISBN: 978-1-0716-2596-5=978-1-0716-2597-2 ; doi:10.1007/978-1-0716-2597-2
Methods in Molecular Biology ISBN: 9781071625965

Tau, a soluble and predominantly neuronal protein, is best known for its microtubule (MT)-binding function in the cytosol, where it decisively contributes to stability as well as modulation of MT dynamics. In Alzheimer's disease and other tauopathies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e777ba461e2c7b59cc939f24412a100d
https://pub.dzne.de/record/165566

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Real-time mechanisms of exacerbated synaptic remodeling by microglia in acute models of systemic inflammation and tauopathy

Autor: Carla Cangalaya, Susanne Wegmann, Weilun Sun, Lisa Diez, Anna Gottfried, Karin Richter, Stoyan Stoyanov, Janelle Pakan, Klaus-Dieter Fischer, Alexander Dityatev

Publikováno v: Brain, behavior and immunity 110, 245-259 (2023). doi:10.1016/j.bbi.2023.02.023

Remodeling of synapses by microglia is essential for synaptic plasticity in the brain. However, during neuroinflammation and neurodegenerative diseases, microglia can induce excessive synaptic loss, although the precise underlying mechanisms are unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ac66009298a90af3f2be58a7d5ee1c9
https://pub.dzne.de/record/257592

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Analysis of Tau/Nucleoporin Interactions by Surface Plasmon Resonance Spectroscopy

Autor: Lisa, Diez, Larisa E, Kapinos, Roderick Y H, Lim, Susanne, Wegmann

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2551

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::34b96377bdb98aa9702c29ad601506ad
https://pubmed.ncbi.nlm.nih.gov/36310199

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Neuroinflammation triggers microglial phagocytosis of synapses via induction of synaptic filopodia

Autor: Carla Cangalaya, Susanne Wegmann, Weilun Sun, Lisa Diez, Anna Gottfried, Karin Richter, Stoyan Stoyanov, Janelle Pakan, Klaus-Dieter Fischer, Alexander Dityatev

Activated microglia play a significant role in synaptic elimination during neuroinflammation, however, the events prior to the uptake of synaptic material by these cells remain elusive. Here, we performed in vivo two-photon imaging of microglia-synap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10dfeb3ae5a34d3af6e56cde9ff28166
https://doi.org/10.21203/rs.3.rs-1795055/v1

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Biomolecular Tau condensation is linked to Tau accumulation at the nuclear envelope

Autor: Janine Hochmair, Christian Exner, Maximilian Franck, Alvaro Dominguez-Baquero, Lisa Diez, Hévila Brognaro, Matthew Kraushar, Thorsten Mielke, Helena Radbruch, Senthil Kaniyappan, Sven Falke, Eckhard Mandelkow, Christian Betzel, Susanne Wegmann

Biomolecular condensation of the neuronal microtubule-associated protein Tau (MAPT) can be induced by coacervation with polyanions like RNA, or by molecular crowding. Tau condensates have been linked to both functional microtubule binding and patholo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::834184adf970a3945197f7cae3a45188
https://doi.org/10.1101/2022.01.24.477544

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Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates

Autor: Janine Hochmair, Christian Exner, Maximilian Franck, Alvaro Dominguez‐Baquero, Lisa Diez, Hévila Brognaro, Matthew L Kraushar, Thorsten Mielke, Helena Radbruch, Senthilvelrajan Kaniyappan, Sven Falke, Eckhard Mandelkow, Christian Betzel, Susanne Wegmann

Publikováno v: The EMBO journal 41(11), e108882 (2022). doi:10.15252/embj.2021108882
The EMBO Journal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf11107f80ba0a09a0f2550364a4977d

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