Výsledky vyhledávání - "Lisa, Broske"

Pharmacokinetics of Pseudoephedrine in Rats, Dogs, Monkeys and Its Pharmacokinetic-Pharmacodynamic Relationship in a Feline Model of Nasal Congestion

Autor: Mccormick Kevin D, Michel R. Corboz, Amin A. Nomeir, Lisa Broske, Jairam Palamanda, Walter A. Korfmacher, Xiaoying Xu, Richard Morrison, Hong Mei, Robbie L. McLeod

Publikováno v: Drug Metabolism Letters. 4:56-61

The objectives of these studies were to characterize the pharmacokinetics (PK) of the nasal decongestant pseudoephedrine (PSE) in rats, dogs, and monkeys, and to evaluate its lower gastrointestinal tract regional bioavailability in rats. An LC-MS/MS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d645e2f6b5aac1ce995373934ba13ac
https://doi.org/10.2174/187231210791292762

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Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery

Autor: Lisa Broske, Paul McNamara, Richard Morrison, David Hesk, Amin A. Nomeir, Hong Mei, Walter A. Korfmacher, Daniel Prelusky

Publikováno v: Journal of Pharmaceutical Sciences. 98:4027-4038

Oral administration is the most desirable route of drug delivery for systemically active drugs. Oral drugs must possess a certain level of oral bioavailability, which is a product of oral absorption and first-pass effect. Low oral bioavailability may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cecd6c8d0593de2f5700d5f1c6aef1
https://doi.org/10.1002/jps.21705

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Use of Pre-Clinical In Vitro and In Vivo Pharmacokinetics for the Selection of a Potent Hepatitis C Virus Protease Inhibitor, Boceprevir, for Clinical Development

Autor: Annette S. Uss, Ganfeng Wang, Samir K. Gupta, Rong Liu, F. George Njoroge, Tongtong Liu, Dan Prelusky, Lisa Broske, Yunsheng Hsieh, Ronald E. White, Anastasia Pavlosky, Cheng Li, K.-C. Cheng

Publikováno v: Letters in Drug Design & Discovery. 6:312-318

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e480d708b3dacfed0ba6c00ed1ee2b4
https://doi.org/10.2174/157018009788452474

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Permeability evaluation of peptidic HCV protease inhibitors in Caco-2 cells-correlation with in vivo absorption predicted in humans

Autor: K.-C. Cheng, Annette S. Uss, Jean-Marc Brisson, Cheng Li, Richard Morrison, Tongtong Liu, Lisa Broske, F. George Njoroge

Publikováno v: Biochemical Pharmacology. 76:1757-1764

The permeability of six peptidic hepatitis C virus (HCV) protease inhibitors, with molecular weights ranging from 500 to 780, was examined in the Caco-2 cell system. All six compounds permeated the cells transcellularly; paracellular permeability, ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be085302d63c0de087bb2550828f83e
https://doi.org/10.1016/j.bcp.2008.09.005

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Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection

Autor: Weidong Pan, Prudence Bradley, Kevin X. Chen, Parekh Tejal N, Andrea Hart, Frank Bennett, Danial Prelusky, Srikanth Venkatraman, Robert Chase, Susan Bogdanowich-Knipp, Jianshe Kong, Bancha Vibulbhan, Viyyoor M. Girijavallabhan, Hendrata Siska, Rong Kong, Weiying Yang, Kuo-Chi Cheng, Ashit K. Ganguly, Nancy Butkiewicz, Ashok Arasappan, Yuhua Huang, Andrew Prongay, Bruce A. Malcolm, Xiang Liang, Rong Liu, Xiaoming Cui, Walter A. Korfmacher, Sony Agrawal, Wanli Wu, Zhuyan Guo, Stephane L. Bogen, Pike Russell E, Ronald E. White, Jesse Wong, Yi-Tsung Liu, Jean-Marc Brisson, John Pichardo, Anil K. Saksena, Pavlovsky Anastasia, Bahige M. Baroudy, F. George Njoroge, Vincent Madison, Patrick Pinto, Santhanam Bama, Raymond G. Lovey, Edwin Jao, Lisa Broske, Veljko Popov, Yunsheng Hsieh, Paul Ingravallo, Sumei Ruan, Piwinski John J

Publikováno v: Journal of Medicinal Chemistry. 49:6074-6086

Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, which affects more than 170 million people worldwide. Currently the only therapeutic regimens are subcutaneous interfero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b1025f20fc929de7fcc2e4ce1f01669
https://doi.org/10.1021/jm060325b

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Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Autor: Sam Wainhaus, Dan Prelusky, Amin A. Nomeir, Kwokei J. Ng, Ronald E. White, Kathleen Cox, J. Veals, Walter A. Korfmacher, Yunsheng Hsieh, Lisa Broske

Publikováno v: Rapid Communications in Mass Spectrometry. 15:335-340

This report addresses the continuing need for increased throughput in the evaluation of new chemical entities (NCEs) in terms of their pharmacokinetic (PK) parameters by describing an alternative procedure for increasing the throughput of the in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2415b9bf4989bd2349a8af3f4cbd940
https://doi.org/10.1002/rcm.235

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The role of P-glycoprotein in the pharmacokinetics and tissue distribution of a hepatitis C virus protease inhibitor

Autor: Lisa Broske, Kevin X. Chen, Tongtong Liu, Cheng Li, K.-C. Cheng, Bancha Vibulbhan, F. George Njoroge, Genfeng Wang, Annette S. Uss

Publikováno v: Drug metabolism letters. 3(4)

S5, a hepatitis C virus protease inhibitor, displays partially saturable efflux in the Caco-2 system. In addition, the efflux can be reversed by cyclosporine, indicating that S5 may be a human P-glycoprotein (P-gp) substrate. S5 can also activate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be73ff378248db3981cbebdc5f3237ef
https://pubmed.ncbi.nlm.nih.gov/19995330

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Discovery of (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]- 3-[2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection

Autor: Srikanth, Venkatraman, Stéphane L, Bogen, Ashok, Arasappan, Frank, Bennett, Kevin, Chen, Edwin, Jao, Yi-Tsung, Liu, Raymond, Lovey, Siska, Hendrata, Yuhua, Huang, Weidong, Pan, Tejal, Parekh, Patrick, Pinto, Veljko, Popov, Russel, Pike, Sumei, Ruan, Bama, Santhanam, Bancha, Vibulbhan, Wanli, Wu, Weiying, Yang, Jianshe, Kong, Xiang, Liang, Jesse, Wong, Rong, Liu, Nancy, Butkiewicz, Robert, Chase, Andrea, Hart, Sony, Agrawal, Paul, Ingravallo, John, Pichardo, Rong, Kong, Bahige, Baroudy, Bruce, Malcolm, Zhuyan, Guo, Andrew, Prongay, Vincent, Madison, Lisa, Broske, Xiaoming, Cui, Kuo-Chi, Cheng, Yunsheng, Hsieh, Jean-Marc, Brisson, Danial, Prelusky, Walter, Korfmacher, Ronald, White, Susan, Bogdanowich-Knipp, Anastasia, Pavlovsky, Prudence, Bradley, Anil K, Saksena, Ashit, Ganguly, John, Piwinski, Viyyoor, Girijavallabhan, F George, Njoroge

Publikováno v: Journal of medicinal chemistry. 49(20)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d829742096e46d140179bde31ce0d830
https://pubmed.ncbi.nlm.nih.gov/17004721

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A study of common discovery dosing formulation components and their potential for causing time-dependent matrix effects in high-performance liquid chromatography tandem mass spectrometry assays

Autor: Lisa Broske, Adrienne Pena, Hong Mei, Shiyong Wang, Walter A. Korfmacher, Ganfeng Wang, Qiao Zhou, Xiaoying Xu

Publikováno v: Rapid communications in mass spectrometry : RCM. 19(18)

Hydroxyproyl-beta-cyclodextran (HPBCD), methyl cellulose (MC), Tween 80 and PEG400 are commonly used in dosing formulations in pharmacokinetic (PK) studies during the early drug discovery stage. A series of studies was designed to evaluate the potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d54799bc37bbf0862c3878a03cc8fc0
https://pubmed.ncbi.nlm.nih.gov/16124030

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