Case Report: Sequential Development of Three Mature Lymphoid Neoplasms in a Single Patient: Clonal Relationship and Molecular Insights

Autor: Chiara Salvetti, Candida Vitale, Valentina Griggio, Daniela Drandi, Rebecca Jones, Lisa Bonello, Riccardo Bomben, Alberto Bragoni, Davide Bagnara, Franco Fais, Valter Gattei, Federica Cavallo, Alberto Zamò, Marta Coscia

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Two main variants of Richter syndrome (RS) are recognized, namely, the diffuse large B-cell lymphoma (DLBCL) and the Hodgkin’s lymphoma (HL) variant. Clonal relationship, defined as an identity of the immunoglobulin heavy chain variable (IGHV) regi

Externí odkaz: https://doaj.org/article/d6713a2ace5046119295bf31f8366cdd

BTK and PLCG2 remain unmutated in one third of patients with CLL relapsing on ibrutinib

Autor: Silvia Bonfiglio, Lesley-Ann Sutton, Viktor Ljungström, Antonella Capasso, Tatjana Pandzic, Simone Weström, Hassan Foroughi-Asl, Aron Skaftason, Anna Gellerbring, Anna Lyander, Francesca Gandini, Gianluca Gaidano, Livio Trentin, Lisa Bonello, Gianluigi Reda, Csaba Bödör, Niki Stavroyianni, Constantine S. Tam, Roberto Marasca, Francesco Forconi, Panayiotis Panayiotidis, Ingo Ringshausen, Ozren Jaksic, Anna Maria Frustaci, Sunil Iyengar, Marta Coscia, Stephen P. Mulligan, Loïc Ysebaert, Vladimir Strugov, Carolina Pavlovsky, Renata Walewska, Anders Österborg, Diego Cortese, Pamela Ranghetti, Panagiotis Baliakas, Kostas Stamatopoulos, Lydia Scarfò, Richard Rosenquist, Paolo Ghia

Publikováno v: Blood Advances

Patients with chronic lymphocytic leukemia (CLL) progressing on ibrutinib constitute an unmet clinical need. Though BTK and PLCG2 mutations are associated with ibrutinib resistance, their frequency and relevance to progression are not fully understoo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad2c7ae912b770d9360cb931fa52e0de
https://hdl.handle.net/2318/1888045

Higher-order connections between stereotyped subsets

Autor: Andrea Patriarca, Marco Montillo, Niki Stavroyianni, Claudia Haferlach, Lesley-Ann Sutton, Livio Trentin, Franco Fais, Raphael Sandaltzopoulos, Arnon P. Kater, Anton W. Langerak, Marine Armand, Davide Rossi, Diane F. Jelinek, Davide Bagnara, Lydia Scarfò, Andreas Agathangelidis, Krzysztof Giannopoulos, Eugen Tausch, Andrey Sudarikov, Silvio Veronese, Salem H. Alshemmari, B V Biderman, Zadie Davis, Chrysoula Belessi, Lisa Bonello, Achilles Anagnostopoulos, Gerlinde Mitterbauer-Hohendanner, David Oscier, Sofia Kossida, Lone Bredo Pedersen, Paolo Ghia, Csaba Bödör, Christian Brieghel, Andrea Visentin, Véronique Giudicelli, Matthias Ritgen, Panagiotis Panagiotidis, Panagiotis Baliakas, Stephan Stilgenbauer, Ellen J van Gastel, Renee C. Tschumper, Christiane Pott, Frederic Davi, Katerina Gemenetzi, Valentina Guido, Elias Campo, Gianluca Gaidano, Irina Panovska, Sabine Jeromin, Karla Plevová, Kostas Stamatopoulos, Kamila Brázdilová, Maria Karypidou, Alba Navarro, Christof W. Schneider, Theodoros Moysiadis, Larry Mansouri, Darko Antic, Cristina Tresoldi, Constance Baer, Šárka Pospíšilová, Maria Roumelioti, Katrina Vanura, Xiao-Jie Yan, Hana Skuhrová Francová, Richard Rosenquist, Blanca Espinet, Paola Francia di Celle, Monica Facco, Paul Costeas, Michael Hallek, Carsten Utoft Niemann, Teodora Karan-Djurasevic, Manja Meggendorfer, Kirsten Fischer, Aleksandar Dimovski, Letizia Foroni, Marie-Paule Lefranc, Mark Catherwood, Anne de Septenville, Anastasia Chatzidimitriou, Sarah Lawless, Nicholas Chiorazzi

Publikováno v: ERIC, the European Research Initiative on CLL 2021, ' Higher-order connections between stereotyped subsets : implications for improved patient classification in CLL ', Blood, vol. 137, no. 10, pp. 1365-1376 . https://doi.org/10.1182/blood.2020007039
Blood, 137(10), 1365-1376. American Society of Hematology
Blood

Chronic lymphocytic leukemia (CLL) is characterized by the existence of subsets of patients with (quasi)identical, stereotyped B-cell receptor (BcR) immunoglobulins. Patients in certain major stereotyped subsets often display remarkably consistent cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345d10461f72781148bcaddc188ba32d
http://www.scopus.com/inward/record.url?scp=85102607193&partnerID=8YFLogxK

Frequent mutations of FBXO11 highlight BCL6 as a therapeutic target in Burkitt lymphoma

Autor: Jonathan Whitfield, Louis M. Staudt, Stephan H. Bernhart, Teresa Poggio, Luca Molinaro, Fernanda Langellotto, Taek-Chin Cheong, Martina Olivero, Chiara Pighi, Alberto Zamò, Riccardo Dall'Olio, Mara Compagno, Qi Wang, Cristina López, Ryan D. Morin, Sandra Martínez-Martín, B. M. Grande, Roberto Chiarle, Maddalena Arigoni, Laura Soucek, Paola Francia di Celle, Raffaele A. Calogero, Reiner Siebert, Lisa Bonello, Claudia Voena, Enrico Patrucco

Publikováno v: Blood Adv
Blood Advances 2021

The expression of BCL6 in B-cell lymphoma can be deregulated by chromosomal translocations, somatic mutations in the promoter regulatory regions, or reduced proteasome-mediated degradation. FBXO11 was recently identified as a ubiquitin ligase that is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d0b97bedf5045b49734e93dfe708463
http://hdl.handle.net/2318/1833339

Osteoclasts are active in bone forming metastases of prostate cancer patients.

Autor: Ilaria Roato, Patrizia D'Amelio, Eva Gorassini, Anastasia Grimaldi, Lisa Bonello, Cristian Fiori, Luisa Delsedime, Alessandro Tizzani, Alfredo De Libero, Giancarlo Isaia, Riccardo Ferracini

Publikováno v: PLoS ONE, Vol 3, Iss 11, p e3627 (2008)

BACKGROUND: Bone forming metastases are a common and disabling consequence of prostate cancer (CaP). The potential role of osteoclast activity in CaP bone metastases is not completely explained. In this study, we investigated ex vivo whether the oste

Externí odkaz: https://doaj.org/article/fa7caa790c9246498bbbe9a24fae8772