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pro vyhledávání: '"Lisa, Aimone"'
Autor:
Babu G, Sundar, Thomas, Bailey, Edward, Bacon, Lisa, Aimone, Zeqi, Huang, Jacquelyn, Lyons, Rita, Raddatz, Robert, Hudkins
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
Pyridazinone 1 was recently reported as a potent H(3)R antagonist with good drug-like properties and in vivo activity. A series of constrained amine analogs of 1 was synthesized to identify compounds with improved pharmacokinetic profiles. From these