Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lis C. Puga-Molina"'
Autor:
Juan J. Ferreira, Chinwendu Amazu, Lis C. Puga-Molina, Xiaofeng Ma, Sarah K. England, Celia M. Santi
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103210- (2021)
Summary: Depolarization of the myometrial smooth muscle cell (MSMC) resting membrane potential is necessary for the uterus to transition from a quiescent state to a contractile state. The molecular mechanisms involved in this transition are not compl
Externí odkaz:
https://doaj.org/article/7110ec77e6cd4632b93850830151803b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization. In mo
Externí odkaz:
https://doaj.org/article/5c7b401e06744fbb91fd037f30bd3071
Autor:
Maximilian Lyon, Ping Li, Juan J. Ferreira, Roman M. Lazarenko, Sujay V. Kharade, Meghan Kramer, Samantha J. McClenahan, Emily Days, Joshua A. Bauer, Brittany D. Spitznagel, C. David Weaver, Aluet Borrego Alvarez, Lis C. Puga Molina, Pascale Lybaert, Saayli Khambekar, Alicia Liu, Craig W. Lindsley, Jerod Denton, Celia M. Santi
Publikováno v:
Proceedings of the National Academy of Sciences. 120
To fertilize an oocyte, the membrane potential of both mouse and human sperm must hyperpolarize (become more negative inside). Determining the molecular mechanisms underlying this hyperpolarization is vital for developing new contraceptive methods an
Publikováno v:
F&S Reviews. 2:317-329
The prevalence of obesity and diabetes, two of the most prevalent metabolic disorders (MetDs) in the world, has been rising exponentially over the last two decades. In addition to other comorbidities, MetDs have a detrimental impact on reproductive f
Autor:
Nicholas C. Spies, Celia M. Santi, Joan K. Riley, Paula A. Balestrini, Mariano G. Buffone, Lis C. Puga Molina, Emily S. Jungheim, Stephanie Gunderson
Publikováno v:
Fertility and Sterility. 115:930-939
Objective To measure human sperm intracellular pH (pHi) and develop a machine-learning algorithm to predict successful conventional in vitro fertilization (IVF) in normospermic patients. Design Spermatozoa from 76 IVF patients were capacitated in vit
Autor:
Lis C. Puga-Molina, Xiaofeng Ma, Chinwendu Amazu, Juan J. Ferreira, Celia M. Santi, Sarah K. England
Publikováno v:
iScience
iScience, Vol 24, Iss 11, Pp 103210-(2021)
iScience, Vol 24, Iss 11, Pp 103210-(2021)
Summary Depolarization of the myometrial smooth muscle cell (MSMC) resting membrane potential is necessary for the uterus to transition from a quiescent state to a contractile state. The molecular mechanisms involved in this transition are not comple
Autor:
Thomas Rossetti, Lis C. Puga Molina, Makoto Fushimi, Jochen Buck, Dagmar Wachten, Dario Krapf, Lonny R. Levin, Lubna Ghanem, Carla Ritagliati, Melanie Balbach, Navpreet Kaur, Jacob Ferreira, Peter T. Meinke, Jan N. Hansen, Celia M. Santi
Publikováno v:
Mol Hum Reprod
Soluble adenylyl cyclase (sAC: ADCY10) has been genetically confirmed to be essential for male fertility in mice and humans. In mice, ex vivo studies of dormant, caudal epididymal sperm demonstrated that sAC is required for initiating capacitation an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff990e408dd249230cc26942d0d9a63a
https://doi.org/10.1101/2021.04.27.441671
https://doi.org/10.1101/2021.04.27.441671
Autor:
Chinwendu Amazu, Sarah K. England, Celia M. Santi, Juan J. Ferreira, Xiaofeng Ma, Lis C. Puga-Molina
Depolarization of the myometrial smooth muscle cell (MSMC) resting membrane potential is necessary for the transition of the uterus from a quiescent state to a contractile state. The molecular mechanisms involved in this transition are not completely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6152e4401e122a820db08ec39e24122d
https://doi.org/10.1101/2020.07.31.229138
https://doi.org/10.1101/2020.07.31.229138
Autor:
Aluet Borrego-Alvarez, Emily S. Jungheim, Lis C. Puga Molina, Stephanie Gunderson, Joanne Riley, Celia Cm Santi, Pascale Lybaert
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2020)
Frontiers in Cell and Developmental Biology, 7
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, 7
Frontiers in Cell and Developmental Biology
Infertility affects 10 to 15% of couples worldwide, with a male factor contributing up to 50% of these cases. The primary tool for diagnosing male infertility is traditional semen analysis, which reveals sperm concentration, morphology, and motility.
Autor:
Vanina Gabriela Da Ros, Lis C. Puga Molina, Mariano G. Buffone, Sol Yanel Nuñez, Nicolás Gastón Brukman, Patricia S. Cuasnicú, Alberto Darszon
Publikováno v:
Journal of Cellular Physiology. 234:5276-5288
Capacitation is a mandatory process for the acquisition of mammalian sperm fertilization competence and involves the activation of a complex and still not fully understood system of signaling pathways. Under in vitro conditions, there is an increase